Role of D1 and D2 Dopamine Receptors in Pilocarpine-Induced Seizures

Both substantia nigra (SN) and caudate-putamen (CP) are brain regions documented to be involved in the regulation of seizure susceptibility (Gale, 1984). Nigral microinjection of gamma-amino-butyric-acid (GABA) agonists or antagonists respectively attenuates or potentiates seizures in several experimental models of epilepsy (Iadarola and Gale, 1982; Turski et al., 1986, 1987a). Similarly, pilocarpine induced-seizures convulsions are prevented by chemical stimulation of striatal cells but facilitated by lesioning of the caudateputamen (Turski et al., 1987b).

[1]  J. McNamara,et al.  Evidence implicating substantia nigra in regulation of kindled seizure threshold , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[2]  T. Chase,et al.  The D1 dopamine receptor in the rat brain: Quantitative autoradiographic localization using an iodinated ligand , 1988, Neuroscience.

[3]  E. Cavalheiro,et al.  Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study , 1983, Behavioural Brain Research.

[4]  J. Kebabian,et al.  Multiple receptors for dopamine , 1979, Nature.

[5]  M. Iadarola,et al.  Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid. , 1982, Science.

[6]  Z. Bortolotto,et al.  Paradoxical anticonvulsant activity of the excitatory amino acid N-methyl-D-aspartate in the rat caudate-putamen. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[7]  J. Girault,et al.  In vivo release of [3H]γ-aminobutyric acid in the rat neostriatum—I. Characterization and topographical heterogeneity of the effects of dopaminergic and cholinergic agents , 1986, Neuroscience.

[8]  J. Korf,et al.  Dopamine release in substantia nigra? , 1976, Nature.

[9]  W. Löscher.  Influence of pharmacological manipulation of inhibitory and excitatory neurotransmitter systems on seizure behavior in the Mongolian gerbil. , 1985, Journal of Pharmacology and Experimental Therapeutics.

[10]  T. Chase,et al.  D-1 dopamine receptor changes after striatal quinolinic acid lesion. , 1987, European journal of pharmacology.

[11]  B. Meldrum,et al.  Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: Effects of intranigral 2-amino-7-phosphonoheptanoate and n-methyl-d-aspartate , 1986, Neuroscience.

[12]  J. C. Stoof,et al.  Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum , 1981, Nature.

[13]  M. Kilian,et al.  Central monoamines and convulsine thresholds in mice and rats. , 1973, Neuropharmacology.

[14]  W. Löscher,et al.  Studies on the involvement of dopamine D-1 and D-2 receptors in the anticonvulsant effect of dopamine agonists in various rodent models of epilepsy. , 1986, European journal of pharmacology.

[15]  T. Klockgether,et al.  Susceptibility to seizures produced by pilocarpine in rats after microinjection of isonnazid or γ-vinyl-GABA into the substantia nigra , 1986, Brain Research.

[16]  M. Trimble,et al.  Drugs modifying dopaminergic activity and behaviour, the EEG and epilepsy in Papio papio. , 1975, European journal of pharmacology.

[17]  R. Fariello,et al.  MPTP and convulsive responses in rodents , 1987, Brain Research.

[18]  S. Z. Langer,et al.  INHIBITION BY APOMORPHINE OF THE POTASSIUM‐EVOKED RELEASE OF [3H]‐γ‐AMINOBUTYRIC ACID FROM THE RAT SUBSTANTIA NIGRA in vitro , 1981, British journal of pharmacology.

[19]  W. Turski,et al.  Dopamine-sensitive anticonvulsant site in the rat striatum , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.