The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth.

[1]  Y. Jan,et al.  Hippocampal Neuronal Polarity Specified by Spatially Localized mPar3/mPar6 and PI 3-Kinase Activity , 2003, Cell.

[2]  A. Püschel,et al.  The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity , 2004, Nature Neuroscience.

[3]  C. Waterman-Storer,et al.  Conserved microtubule–actin interactions in cell movement and morphogenesis , 2003, Nature Cell Biology.

[4]  T. Schroer,et al.  Dynactin increases the processivity of the cytoplasmic dynein motor , 1999, Nature Cell Biology.

[5]  K. W. Lo,et al.  Structure of Tctex-1 and Its Interaction with Cytoplasmic Dynein Intermediate Chain* , 2001, The Journal of Biological Chemistry.

[6]  L. Tsai,et al.  Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning , 2004, Neuron.

[7]  Zuoshang Xu,et al.  An enhanced U6 promoter for synthesis of short hairpin RNA. , 2003, Nucleic acids research.

[8]  Carlos G. Dotti,et al.  Breaking the neuronal sphere: regulation of the actin cytoskeleton in neuritogenesis , 2002, Nature Reviews Neuroscience.

[9]  N. Hirokawa,et al.  Kinesin and dynein superfamily proteins and the mechanism of organelle transport. , 1998, Science.

[10]  G. Banker,et al.  Local Presentation of Substrate Molecules Directs Axon Specification by Cultured Hippocampal Neurons , 1999, The Journal of Neuroscience.

[11]  K. Kaibuchi,et al.  CRMP-2 binds to tubulin heterodimers to promote microtubule assembly , 2002, Nature Cell Biology.

[12]  C. Waterman-Storer,et al.  The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[13]  T. Schroer,et al.  Analysis of the dynein-dynactin interaction in vitro and in vivo. , 2003, Molecular biology of the cell.

[14]  T. Yagi,et al.  Molecular cloning of Fyn‐associated molecules in the mouse central nervous system , 1997, Journal of neuroscience research.

[15]  K. Kosik,et al.  Suppression of Radixin and Moesin Alters Growth Cone Morphology, Motility, and Process Formation In Primary Cultured Neurons , 1998, The Journal of cell biology.

[16]  Leif Dehmelt,et al.  Actin and microtubules in neurite initiation: are MAPs the missing link? , 2004, Journal of neurobiology.

[17]  C. Waterman-Storer,et al.  Cell motility: can Rho GTPases and microtubules point the way? , 2001, Journal of cell science.

[18]  L. Luo.  RHO GTPASES in neuronal morphogenesis , 2000, Nature Reviews Neuroscience.

[19]  Richard Threadgill,et al.  Regulation of Dendritic Growth and Remodeling by Rho, Rac, and Cdc42 , 1997, Neuron.

[20]  S. J. Smith,et al.  Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone , 1988, The Journal of cell biology.

[21]  S. Pfeffer,et al.  Cytoplasmic dynein participates in the centrosomal localization of the Golgi complex , 1992, The Journal of cell biology.

[22]  S. Aaronson,et al.  Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product , 1991, Nature.

[23]  C. Sung,et al.  Subunit Heterogeneity of Cytoplasmic Dynein: Differential Expression of 14 kDa Dynein Light Chains in Rat Hippocampus , 2001, The Journal of Neuroscience.

[24]  E. Salmon,et al.  Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts , 1999, Nature Cell Biology.

[25]  K. Kaibuchi,et al.  Axon specification in hippocampal neurons , 2002, Neuroscience Research.

[26]  Torsten Wittmann,et al.  Motor proteins regulate force interactions between microtubules and microfilaments in the axon , 2000, Nature Cell Biology.

[27]  C. Echeverri,et al.  Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis , 1996, The Journal of cell biology.

[28]  D. Howland,et al.  Disruption of Dynein/Dynactin Inhibits Axonal Transport in Motor Neurons Causing Late-Onset Progressive Degeneration , 2002, Neuron.

[29]  K. Kaibuchi,et al.  CRMP-2 induces axons in cultured hippocampal neurons , 2001, Nature Neuroscience.

[30]  Ann Y. Nakayama,et al.  Small GTPases Rac and Rho in the Maintenance of Dendritic Spines and Branches in Hippocampal Pyramidal Neurons , 2000, The Journal of Neuroscience.

[31]  Adriana B Ferreira,et al.  LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons. , 2004, Molecular biology of the cell.

[32]  M. Nikolic.  The role of Rho GTPases and associated kinases in regulating neurite outgrowth. , 2002, The international journal of biochemistry & cell biology.

[33]  R. Vallee,et al.  Dynein: An ancient motor protein involved in multiple modes of transport. , 2004, Journal of neurobiology.

[34]  N. Hirokawa.  Stirring up Development with the Heterotrimeric Kinesin KIF3 , 2000, Traffic.

[35]  C. Sung,et al.  Localization of Tctex-1, a Cytoplasmic Dynein Light Chain, to the Golgi Apparatus and Evidence for Dynein Complex Heterogeneity* , 1998, The Journal of Biological Chemistry.

[36]  P. De Camilli,et al.  The distribution of synapsin I and synaptophysin in hippocampal neurons developing in culture , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[37]  S. Kuroda,et al.  Rac1 and Cdc42 Capture Microtubules through IQGAP1 and CLIP-170 , 2002, Cell.

[38]  M. Hatten,et al.  Par6α signaling controls glial-guided neuronal migration , 2004, Nature Neuroscience.

[39]  E. Newman,et al.  The Drosophila tctex-1 light chain is dispensable for essential cytoplasmic dynein functions but is required during spermatid differentiation. , 2004, Molecular biology of the cell.

[40]  S. Dedhar,et al.  NGF-Induced Axon Growth Is Mediated by Localized Inactivation of GSK-3β and Functions of the Microtubule Plus End Binding Protein APC , 2004, Neuron.

[41]  A. Ferreira,et al.  Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau. , 1989, Brain research. Developmental brain research.

[42]  C. Sung,et al.  Cytoplasmic Dynein Regulation by Subunit Heterogeneity and Its Role in Apical Transport , 2001, The Journal of cell biology.

[43]  K. Kosik,et al.  Evidence for the Involvement of Tiam1 in Axon Formation , 2001, The Journal of Neuroscience.

[44]  A. Brown,et al.  Sites of microtubule stabilization for the axon , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[45]  G. Banker,et al.  The establishment of polarity by hippocampal neurons in culture , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[46]  U. Wolfrum,et al.  Rhodopsin’s Carboxy-Terminal Cytoplasmic Tail Acts as a Membrane Receptor for Cytoplasmic Dynein by Binding to the Dynein Light Chain Tctex-1 , 1999, Cell.

[47]  C. Dotti,et al.  The role of local actin instability in axon formation. , 1999, Science.