Three-dimensional hMSC motility within peptide-functionalized PEG-based hydrogels of varying adhesivity and crosslinking density.

[1]  Richard B. Dickinson,et al.  Optimal estimation of cell movement indices from the statistical analysis of cell tracking data , 1993 .

[2]  G. Fields,et al.  Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides. , 1996, Biopolymers.

[3]  Sean P. Palecek,et al.  Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness , 1997, Nature.

[4]  Sean P. Palecek,et al.  Erratum: Integrin–ligand binding properties govern cell migration speed through cell–substratum adhesiveness , 1997, Nature.

[5]  Y. Wang,et al.  Cell locomotion and focal adhesions are regulated by substrate flexibility. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[6]  D J Prockop,et al.  Donor variation in the growth properties and osteogenic potential of human marrow stromal cells , 1999, Journal of cellular biochemistry.

[7]  M. Dembo,et al.  Cell movement is guided by the rigidity of the substrate. , 2000, Biophysical journal.

[8]  L G Griffith,et al.  Cell adhesion and motility depend on nanoscale RGD clustering. , 2000, Journal of cell science.

[9]  Micah Dembo,et al.  Influence of type I collagen surface density on fibroblast spreading, motility, and contractility. , 2003, Biophysical journal.

[10]  Dennis Discher,et al.  Substrate compliance versus ligand density in cell on gel responses. , 2004, Biophysical journal.

[11]  J. Hubbell,et al.  Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration. , 2005, Biophysical journal.

[12]  T. Salo,et al.  Human mesenchymal stem cell derived osteoblasts degrade organic bone matrix in vitro by matrix metalloproteinases. , 2005, Matrix biology : journal of the International Society for Matrix Biology.

[13]  Shelly R. Peyton,et al.  Extracellular matrix rigidity governs smooth muscle cell motility in a biphasic fashion , 2005, Journal of cellular physiology.

[14]  Adam Byron,et al.  Integrin ligands at a glance , 2006, Journal of Cell Science.

[15]  S. Sen,et al.  Matrix Elasticity Directs Stem Cell Lineage Specification , 2006, Cell.

[16]  J. Hedrick,et al.  Synthesis of well-defined hydrogel networks using click chemistry. , 2006, Chemical communications.

[17]  D. Lauffenburger,et al.  Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[18]  J. Hubbell,et al.  Mechanisms of 3-D migration and matrix remodeling of fibroblasts within artificial ECMs. , 2007, Acta biomaterialia.

[19]  F. Canovas,et al.  Microenvironmental changes during differentiation of mesenchymal stem cells towards chondrocytes , 2007, Arthritis research & therapy.

[20]  A. Uccelli,et al.  Mesenchymal stem cells in health and disease , 2008, Nature Reviews Immunology.

[21]  Yuji Yamamoto,et al.  Design and Fabrication of a High-Strength Hydrogel with Ideally Homogeneous Network Structure from Tetrahedron-like Macromonomers , 2008 .

[22]  Kenneth M. Yamada,et al.  Direct visualization of protease activity on cells migrating in three-dimensions. , 2009, Matrix Biology.

[23]  Kristi S. Anseth,et al.  A Versatile Synthetic Extracellular Matrix Mimic via Thiol‐Norbornene Photopolymerization , 2009, Advanced materials.

[24]  Kenneth M. Yamada,et al.  One-dimensional topography underlies three-dimensional fibrillar cell migration , 2009, The Journal of cell biology.

[25]  David J. Mooney,et al.  Growth Factors, Matrices, and Forces Combine and Control Stem Cells , 2009, Science.

[26]  Matthias P. Lutolf,et al.  Designing materials to direct stem-cell fate , 2009, Nature.

[27]  P. Lam,et al.  Matrix Metalloproteinase 1 Is Necessary for the Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells Toward Human Glioma , 2009, Stem cells.

[28]  Kristi S Anseth,et al.  Photoinitiated polymerization of PEG-diacrylate with lithium phenyl-2,4,6-trimethylbenzoylphosphinate: polymerization rate and cytocompatibility. , 2009, Biomaterials.

[29]  S. Gerecht,et al.  Vascular endothelial growth factor and substrate mechanics regulate in vitro tubulogenesis of endothelial progenitor cells , 2009, Journal of cellular and molecular medicine.

[30]  P. Friedl,et al.  The Journal of Cell Biology , 2002 .

[31]  K. Anseth,et al.  A synthetic strategy for mimicking the extracellular matrix provides new insight about tumor cell migration. , 2010, Integrative biology : quantitative biosciences from nano to macro.

[32]  C. Thiemermann,et al.  Mesenchymal Stromal Cells: Current Understanding and Clinical Status , 2009, Stem cells.

[33]  J. Hubbell,et al.  Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. , 2010, Biomaterials.

[34]  Frederick Grinnell,et al.  Cell motility and mechanics in three-dimensional collagen matrices. , 2010, Annual review of cell and developmental biology.

[35]  S. Halfon,et al.  Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging. , 2011, Stem cells and development.

[36]  S. Rizzi,et al.  Elucidating the role of matrix stiffness in 3D cell migration and remodeling. , 2011, Biophysical journal.

[37]  D. Lauffenburger,et al.  Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling. , 2011, Biomaterials.

[38]  L. Dai,et al.  Substrate stiffness regulates apoptosis and the mRNA expression of extracellular matrix regulatory genes in the rat annular cells. , 2011, Matrix biology : journal of the International Society for Matrix Biology.

[39]  Douglas A Lauffenburger,et al.  Marrow‐Derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness , 2010, Biotechnology and bioengineering.

[40]  Kenneth M. Yamada,et al.  Direct comparisons of the morphology, migration, cell adhesions, and actin cytoskeleton of fibroblasts in four different three-dimensional extracellular matrices. , 2011, Tissue engineering. Part A.

[41]  Anders Hult,et al.  Characterization of Well-Defined Poly(ethylene glycol) Hydrogels Prepared by Thiol-ene Chemistry , 2011 .

[42]  Fa-Ming Chen,et al.  Homing of endogenous stem/progenitor cells for in situ tissue regeneration: Promises, strategies, and translational perspectives. , 2011, Biomaterials.

[43]  Kristi S Anseth,et al.  The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels. , 2011, Biomaterials.

[44]  Tatiana Segura,et al.  The spreading, migration and proliferation of mouse mesenchymal stem cells cultured inside hyaluronic acid hydrogels. , 2011, Biomaterials.

[45]  Shelly R. Peyton,et al.  Bio-inspired materials for parsing matrix physicochemical control of cell migration: a review. , 2012, Integrative biology : quantitative biosciences from nano to macro.

[46]  J. Burdick,et al.  Synergistic effects of SDF-1α chemokine and hyaluronic acid release from degradable hydrogels on directing bone marrow derived cell homing to the myocardium. , 2012, Biomaterials.

[47]  Kristi S Anseth,et al.  Photoreversible Patterning of Biomolecules within Click-Based Hydrogels , 2011, Angewandte Chemie.

[48]  Kristi S Anseth,et al.  Small peptide functionalized thiol-ene hydrogels as culture substrates for understanding valvular interstitial cell activation and de novo tissue deposition. , 2012, Acta biomaterialia.