The impact of metabotropic glutamate receptors into active neurodegenerative processes: A “dark side” in the development of new symptomatic treatments for neurologic and psychiatric disorders
暂无分享,去创建一个
[1] C. Ibáñez,et al. Biology of GDNF and its receptors — Relevance for disorders of the central nervous system , 2017, Neurobiology of Disease.
[2] K. C. Oliveira,et al. Neuropathological relationship between major depression and dementia: A hypothetical model and review , 2016, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[3] Ofer Pasternak,et al. In vivo imaging of neuroinflammation in schizophrenia , 2016, Schizophrenia Research.
[4] Hongbing Wang,et al. Acute inhibition of mGluR5 disrupts behavioral flexibility , 2016, Neurobiology of Learning and Memory.
[5] N. Belluardo,et al. Current disease modifying approaches to treat Parkinson’s disease , 2016, Cellular and Molecular Life Sciences.
[6] Anthony E. Lang,et al. Parkinson disease in 2015: Evolving basic, pathological and clinical concepts in PD , 2016, Nature Reviews Neurology.
[7] J. Bartolomé-Nebreda,et al. Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia. , 2016, Bioorganic & medicinal chemistry letters.
[8] L. Baki,et al. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia , 2016, Science Signaling.
[9] D. McKinzie,et al. Exploratory Analysis for a Targeted Patient Population Responsive to the Metabotropic Glutamate 2/3 Receptor Agonist Pomaglumetad Methionil in Schizophrenia , 2015, Biological Psychiatry.
[10] B. McEwen,et al. Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity , 2015, Proceedings of the National Academy of Sciences.
[11] Fabio Sambataro,et al. Baseline brain perfusion and brain structure in patients with major depression: a multimodal magnetic resonance imaging study. , 2015, Journal of psychiatry & neuroscience : JPN.
[12] F. Nicoletti,et al. Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage , 2015, Molecular Brain.
[13] H. Morishita,et al. Interneuron epigenomes during the critical period of cortical plasticity: Implications for schizophrenia , 2015, Neurobiology of Learning and Memory.
[14] I. Bezprozvanny,et al. Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease , 2015, The Journal of Neuroscience.
[15] Carla Nasca,et al. Mechanisms of stress in the brain , 2015, Nature Neuroscience.
[16] S. Heckers,et al. GABAergic mechanisms of hippocampal hyperactivity in schizophrenia , 2015, Schizophrenia Research.
[17] F. Benes. The GABA System in Schizophrenia: Cells, Molecules and Microcircuitry , 2015, Schizophrenia Research.
[18] S. Sorbi,et al. Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons , 2015, Front. Cell. Neurosci..
[19] C. Lindsley,et al. Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist , 2015, Neuropharmacology.
[20] N. Simola,et al. Dual target strategy: combining distinct non‐dopaminergic treatments reduces neuronal cell loss and synergistically modulates l‐DOPA‐induced rotational behavior in a rodent model of Parkinson's disease , 2015, Journal of neurochemistry.
[21] D. Lewis,et al. Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia , 2015, Biological Psychiatry.
[22] A. Palmeri,et al. A key role for TGF-β1 in hippocampal synaptic plasticity and memory , 2015, Scientific Reports.
[23] Anil Kumar,et al. Therapeutic potential of mGluR5 targeting in Alzheimer's disease , 2015, Front. Neurosci..
[24] Burkhard Becher,et al. Immune attack: the role of inflammation in Alzheimer disease , 2015, Nature Reviews Neuroscience.
[25] Kari A. Johnson,et al. Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents , 2015, Neuron.
[26] D. Holtzman,et al. Three dimensions of the amyloid hypothesis: time, space and 'wingmen' , 2015, Nature Neuroscience.
[27] C. Sánchez,et al. Treatment of cognitive dysfunction in major depressive disorder--a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine. , 2015, European journal of pharmacology.
[28] C. Sánchez,et al. Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory , 2015, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[29] Stephen R. Morairty,et al. Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression , 2015, The Journal of Pharmacology and Experimental Therapeutics.
[30] M. Buuse,et al. A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive review , 2015, Neuroscience & Biobehavioral Reviews.
[31] T. Schulze,et al. Kraepelin revisited: schizophrenia from degeneration to failed regeneration , 2015, Molecular Psychiatry.
[32] Daniel J Fridberg,et al. Brain-derived neurotrophic factor (BDNF) and neurocognitive deficits in people with schizophrenia: A meta-analysis , 2015, Psychiatry Research.
[33] C. Sánchez,et al. Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine. , 2015, ACS chemical neuroscience.
[34] J. López-Barneo,et al. GDNF-based therapies, GDNF-producing interneurons, and trophic support of the dopaminergic nigrostriatal pathway. Implications for Parkinson’s disease , 2015, Front. Neuroanat..
[35] Yu-ping Peng,et al. Protection of TGF-β1 against Neuroinflammation and Neurodegeneration in Aβ1–42-Induced Alzheimer’s Disease Model Rats , 2015, PloS one.
[36] P. Conn,et al. Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics. , 2015, Current opinion in pharmacology.
[37] Giuseppe Battaglia,et al. Metabotropic glutamate receptors as drug targets: what's new? , 2015, Current opinion in pharmacology.
[38] Giuseppe Battaglia,et al. Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis , 2015, Neurobiology of Disease.
[39] Carl-Fredrik Westin,et al. The extent of diffusion MRI markers of neuroinflammation and white matter deterioration in chronic schizophrenia , 2015, Schizophrenia Research.
[40] Y. Lu,et al. Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice , 2015, Neuroscience.
[41] M. Roca,et al. Cognitive function after clinical remission in patients with melancholic and non-melancholic depression: a 6 month follow-up study. , 2015, Journal of affective disorders.
[42] S. Chaki,et al. Neurophysiologic and Antipsychotic Profiles of TASP0433864, a Novel Positive Allosteric Modulator of Metabotropic Glutamate 2 Receptor , 2014, The Journal of Pharmacology and Experimental Therapeutics.
[43] B. Mulsant,et al. The Role of Untreated Psychosis in Neurodegeneration: A Review of Hypothesized Mechanisms of Neurotoxicity in First-Episode Psychosis , 2014, Canadian journal of psychiatry. Revue canadienne de psychiatrie.
[44] B. Mcewen,et al. Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility , 2014, Molecular Psychiatry.
[45] O. Rascol,et al. Use of metabotropic glutamate 5-receptor antagonists for treatment of levodopa-induced dyskinesias. , 2014, Parkinsonism & related disorders.
[46] S. Strittmatter,et al. Therapeutic Molecules and Endogenous Ligands Regulate the Interaction between Brain Cellular Prion Protein (PrPC) and Metabotropic Glutamate Receptor 5 (mGluR5)* , 2014, The Journal of Biological Chemistry.
[47] M. Ehrlich,et al. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse , 2014, Molecular Psychiatry.
[48] Sarah L. Huszar,et al. Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target , 2014, Neuropharmacology.
[49] P. Kochunov,et al. Neurodevelopmental and neurodegenerative models of schizophrenia: white matter at the center stage. , 2014, Schizophrenia bulletin.
[50] P. Masand,et al. A review of current evidence for acetyl-l-carnitine in the treatment of depression. , 2014, Journal of psychiatric research.
[51] A. Linden,et al. mGluR3 knockout mice show a working memory defect and an enhanced response to MK-801 in the T- and Y-maze cognitive tests , 2014, Behavioural Brain Research.
[52] S. Cregan,et al. Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease , 2014, Molecular Brain.
[53] I. Ito,et al. Comprehensive behavioral study of mGluR3 knockout mice: implication in schizophrenia related endophenotypes , 2014, Molecular Brain.
[54] A. Fasano,et al. Maladaptive Plasticity in Levodopa-Induced Dyskinesias and Tardive Dyskinesias: Old and New Insights on the Effects of Dopamine Receptor Pharmacology , 2014, Front. Neurol..
[55] F. Saravia,et al. Astroglial mGlu3 receptors promote alpha-secretase-mediated amyloid precursor protein cleavage , 2014, Neuropharmacology.
[56] D. Engblom,et al. Mechanisms of Dopamine D1 Receptor-Mediated ERK1/2 Activation in the Parkinsonian Striatum and Their Modulation by Metabotropic Glutamate Receptor Type 5 , 2014, The Journal of Neuroscience.
[57] Kari A. Johnson,et al. Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS , 2014, The Journal of Neuroscience.
[58] M. Cenci,et al. Modulating mGluR5 and 5-HT1A/1B receptors to treat l-DOPA-induced dyskinesia: Effects of combined treatment and possible mechanisms of action , 2013, Experimental Neurology.
[59] A. R. Durrant,et al. Autoimmune-induced glutamatergic receptor dysfunctions: Conceptual and psychiatric practice implications , 2013, European Neuropsychopharmacology.
[60] Gabriel Gold,et al. Alzheimer disease therapy—moving from amyloid-β to tau , 2013, Nature Reviews Neurology.
[61] P. Bargiotas,et al. Levodopa-induced dyskinesias in Parkinson’s disease: emerging treatments , 2013, Neuropsychiatric disease and treatment.
[62] H. Fillit,et al. Progress in novel cognitive enhancers for cognitive aging and Alzheimer’s disease , 2013, Alzheimer's Research & Therapy.
[63] F. S. Bersani,et al. l-Acetylcarnitine in dysthymic disorder in elderly patients: A double-blind, multicenter, controlled randomized study vs. fluoxetine , 2013, European Neuropsychopharmacology.
[64] D. Volk,et al. Prenatal ontogeny as a susceptibility period for cortical GABA neuron disturbances in schizophrenia , 2013, Neuroscience.
[65] A. Vortmeyer,et al. Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein , 2013, Neuron.
[66] K. Nakazawa,et al. Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophrenia , 2013, Front. Behav. Neurosci..
[67] C. Bundgaard,et al. Repeated potentiation of the metabotropic glutamate receptor 5 and the alpha 7 nicotinic acetylcholine receptor modulates behavioural and GABAergic deficits induced by early postnatal phencyclidine (PCP) treatment , 2013, Neuropharmacology.
[68] G. Marek,et al. The two faces of the pharmacological interaction of mGlu2 and 5-HT2A – Relevance of receptor heterocomplexes and interaction through functional brain pathways , 2013, Neuropharmacology.
[69] F. Gasparini,et al. Metabotropic Glutamate Receptors for Parkinson's Disease Therapy , 2013, Parkinson's disease.
[70] J. Krystal,et al. Rapid-Acting Glutamatergic Antidepressants: The Path to Ketamine and Beyond , 2013, Biological Psychiatry.
[71] C. Lindsley,et al. Allosteric modulation of Class C GPCRs: a novel approach for the treatment of CNS disorders. , 2013, Drug Discovery Today : Technologies.
[72] M. Grilli,et al. Upregulation of mGlu2 Receptors via NF-κB p65 Acetylation Is Involved in the Proneurogenic and Antidepressant Effects of Acetyl-L-Carnitine , 2013, Neuropsychopharmacology.
[73] K. Gregory,et al. A Novel Metabotropic Glutamate Receptor 5 Positive Allosteric Modulator Acts at a Unique Site and Confers Stimulus Bias to mGlu5 Signaling , 2013, Molecular Pharmacology.
[74] Santo Di Nuovo,et al. Role of the Transforming-Growth-Factor-β1 Gene in Late-Onset Alzheimer’s Disease: Implications for the Treatment , 2013, Current genomics.
[75] F. Dudek,et al. Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity , 2013, Biological Psychiatry.
[76] P. Gubellini,et al. Synergy between l-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: Implications for Parkinson's disease treatment and dyskinesia , 2013, Neuropharmacology.
[77] Huafu Chen,et al. Decreased left middle temporal gyrus volume in antipsychotic drug-naive, first-episode schizophrenia patients and their healthy unaffected siblings , 2013, Schizophrenia Research.
[78] S. Chaki,et al. mGlu2/3 and mGlu5 receptors: Potential targets for novel antidepressants , 2013, Neuropharmacology.
[79] F. Nicoletti,et al. L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors , 2013, Proceedings of the National Academy of Sciences.
[80] Yuelong Jin,et al. Meta-analysis of the transforming growth factor-β1 polymorphisms and susceptibility to Alzheimer’s disease , 2013, Journal of Neural Transmission.
[81] L. Hurley,et al. Neuroinflammation, Neurodegeneration, and Depression , 2013, Neurotoxicity Research.
[82] D. Umbricht,et al. Cognitive impairment in major depression and the mGlu2 receptor as a therapeutic target , 2013, Neuropharmacology.
[83] S. Russo,et al. Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System , 2013, The Journal of Neuroscience.
[84] D. Vancampfort,et al. An impaired health related muscular fitness contributes to a reduced walking capacity in patients with schizophrenia: a cross-sectional study , 2013, BMC Psychiatry.
[85] Carl-Fredrik Westin,et al. Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset , 2012, The Journal of Neuroscience.
[86] P. Conn,et al. Emerging approaches for treatment of schizophrenia: modulation of cholinergic signaling. , 2012, Discovery medicine.
[87] Y. Zhu,et al. Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine produces antidepressant effects in rats: Role of brain-derived neurotrophic factor , 2012, Neuroscience.
[88] R. von Bernhardi,et al. Transforming growth factor‐β stimulates β amyloid uptake by microglia through Smad3‐dependent mechanisms , 2012, Journal of neuroscience research.
[89] P. Kammermeier. Functional and Pharmacological Characteristics of Metabotropic Glutamate Receptors 2/4 Heterodimers , 2012, Molecular Pharmacology.
[90] Jimmy Lee,et al. A Review of Brain-derived Neurotrophic Factor as a Candidate Biomarker in Schizophrenia , 2012, Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology.
[91] M. Betts,et al. Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6‐hydroxydopamine rat model of Parkinson's disease , 2012, British journal of pharmacology.
[92] J. Bockaert,et al. Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability , 2012, The Journal of cell biology.
[93] T. Lai,et al. Blockade of metabotropic glutamate receptors inhibits cognition and neurodegeneration in an MPTP-induced Parkinson's disease rat model , 2012, Pharmacology Biochemistry and Behavior.
[94] D. Magnuson,et al. Acetyl-l-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery , 2012, Neuroscience.
[95] Vaughan J. Carr,et al. Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia , 2012, Neuroscience & Biobehavioral Reviews.
[96] P. Bosco,et al. The CC genotype of transforming growth factor-β1 increases the risk of late-onset Alzheimer's disease and is associated with AD-related depression , 2012, European Neuropsychopharmacology.
[97] S. Singh,et al. Acetyl‐L‐carnitine‐mediated neuroprotection during hypoxia is attributed to ERK1/2‐Nrf2‐regulated mitochondrial biosynthesis , 2012, Hippocampus.
[98] D. McKinzie,et al. Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia , 2012, Neuropharmacology.
[99] A. Guidotti,et al. Pharmacological Activation of Group-II Metabotropic Glutamate Receptors Corrects a Schizophrenia-Like Phenotype Induced by Prenatal Stress in Mice , 2012, Neuropsychopharmacology.
[100] P. Conn,et al. Metabotropic glutamate receptors as therapeutic targets for schizophrenia , 2012, Neuropharmacology.
[101] D. Lewis,et al. NMDA receptor hypofunction, parvalbumin-positive neurons, and cortical gamma oscillations in schizophrenia. , 2012, Schizophrenia bulletin.
[102] Rui Zhang,et al. Neuroprotective Effects of Pre-Treament with l-Carnitine and Acetyl-l-Carnitine on Ischemic Injury In Vivo and In Vitro , 2012, International journal of molecular sciences.
[103] R. Lefkowitz,et al. Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. , 2012, Annual review of pharmacology and toxicology.
[104] P. Conn,et al. Targeting glutamate synapses in schizophrenia. , 2011, Trends in molecular medicine.
[105] Davide Provasi,et al. Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs , 2011, Cell.
[106] R. Balice-Gordon,et al. Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome , 2011, Neurology.
[107] N. Belluardo,et al. mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum , 2011, Neuropharmacology.
[108] D. Selkoe,et al. Resolving controversies on the path to Alzheimer's therapeutics , 2011, Nature Medicine.
[109] T. Wichmann,et al. Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys. , 2011, Brain : a journal of neurology.
[110] A. Guidotti,et al. Epigenetic GABAergic targets in schizophrenia and bipolar disorder , 2011, Neuropharmacology.
[111] F. Nicoletti,et al. Metabotropic glutamate receptors: From the workbench to the bedside , 2011, Neuropharmacology.
[112] L. Grégoire,et al. The acute antiparkinsonian and antidyskinetic effect of AFQ056, a novel metabotropic glutamate receptor type 5 antagonist, in L-Dopa-treated parkinsonian monkeys. , 2011, Parkinsonism & related disorders.
[113] J. Deussing,et al. Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices , 2011, Neuropharmacology.
[114] R. Boles,et al. Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders , 2011, Progress in Neuro-Psychopharmacology and Biological Psychiatry.
[115] B. Ray,et al. Autism, Alzheimer disease, and fragile X , 2011, Neurology.
[116] E. Nisenbaum,et al. Targeting Group II Metabotropic Glutamate (mGlu) Receptors for the Treatment of Psychosis Associated with Alzheimer's Disease: Selective Activation of mGlu2 Receptors Amplifies β-Amyloid Toxicity in Cultured Neurons, Whereas Dual Activation of mGlu2 and mGlu3 Receptors Is Neuroprotective , 2011, Molecular Pharmacology.
[117] M. Olive,et al. Positive Allosteric Modulators of Type 5 Metabotropic Glutamate Receptors (mGluR5) and Their Therapeutic Potential for the Treatment of CNS Disorders , 2011, Molecules.
[118] Allison C. Nugent,et al. Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder , 2011, NeuroImage.
[119] L. Prézeau,et al. The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors , 2011, Neuropharmacology.
[120] G. Fiskum,et al. Neuroprotection by Acetyl-L-Carnitine after Traumatic Injury to the Immature Rat Brain , 2011, Developmental Neuroscience.
[121] C. Tamminga,et al. Schizophrenia: treatment targets beyond monoamine systems. , 2011, Annual review of pharmacology and toxicology.
[122] Eric Trinquet,et al. A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[123] Del D. Miller,et al. Association between type‐three metabotropic glutamate receptor gene (GRM3) variants and symptom presentation in treatment refractory schizophrenia , 2011, Human psychopharmacology.
[124] A. Brownell,et al. Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease , 2010, Neuroscience Letters.
[125] R. Faull,et al. Altered distribution of mGlu2 receptors in β-amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice , 2010, Brain Research.
[126] P Jeffrey Conn,et al. Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity , 2010, Molecular Pharmacology.
[127] E. Nestler,et al. Linking molecules to mood: new insight into the biology of depression. , 2010, The American journal of psychiatry.
[128] Qin Li,et al. A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys , 2010, Neurobiology of Disease.
[129] W. Surewicz,et al. Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues. , 2010, The Journal of biological chemistry.
[130] W. Klein,et al. Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5 , 2010, Neuron.
[131] L. Grégoire,et al. Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys , 2010, Neuropharmacology.
[132] J. Brotchie,et al. Reduction of l-DOPA-Induced Dyskinesia by the Selective Metabotropic Glutamate Receptor 5 Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Lesioned Macaque Model of Parkinson's Disease , 2010, Journal of Pharmacology and Experimental Therapeutics.
[133] M. Heilig,et al. Alcohol-Induced Neurodegeneration, Suppression of Transforming Growth Factor-β, and Cognitive Impairment in Rats: Prevention by Group II Metabotropic Glutamate Receptor Activation , 2010, Biological Psychiatry.
[134] P. S. St George-Hyslop,et al. Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid β42 from Isolated Intact Nerve Terminals , 2010, The Journal of Neuroscience.
[135] Jen-Chuen Hsieh,et al. Structural and cognitive deficits in remitting and non-remitting recurrent depression: A voxel-based morphometric study , 2010, NeuroImage.
[136] N. Belluardo,et al. Group II metabotropic glutamate receptor activation by agonist LY379268 treatment increases the expression of brain derived neurotrophic factor in the mouse brain , 2010, Neuroscience.
[137] W. Singer,et al. Abnormal neural oscillations and synchrony in schizophrenia , 2010, Nature Reviews Neuroscience.
[138] Osamu Abe,et al. Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression , 2010, Psychiatry Research: Neuroimaging.
[139] W. Deng,et al. Changes of Brain Morphometry in First-Episode, Drug-Naïve, Non–Late-Life Adult Patients with Major Depression: An Optimized Voxel-Based Morphometry Study , 2010, Biological Psychiatry.
[140] P. Conn,et al. Metabotropic glutamate receptors: physiology, pharmacology, and disease. , 2010, Annual review of pharmacology and toxicology.
[141] M. Cenci,et al. Plastic effects of L-DOPA treatment in the basal ganglia and their relevance to the development of dyskinesia. , 2009, Parkinsonism & related disorders.
[142] W. Danysz,et al. Comparison of the mGlu(5) receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activity. , 2009, European journal of pharmacology.
[143] S. Kapur,et al. Candidate-gene association analysis of response to risperidone in African-American and white patients with schizophrenia , 2009, The Pharmacogenomics Journal.
[144] N. Belluardo,et al. Activation of mGlu3 Receptors Stimulates the Production of GDNF in Striatal Neurons , 2009, PloS one.
[145] E. Nestler,et al. Psychobiology and molecular genetics of resilience , 2009, Nature Reviews Neuroscience.
[146] G. Zamponi. Faculty Opinions recommendation of Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. , 2009 .
[147] John W. Gilbert,et al. Cellular Prion Protein Mediates Impairment of Synaptic Plasticity by Amyloid-β Oligomers , 2009, Nature.
[148] E. Fernandes,et al. Acetyl-l-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain , 2009, Neuroscience.
[149] F. Liu,et al. ADX47273 [S-(4-Fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Modulator with Preclinical Antipsychotic-Like and Procognitive Activities , 2008, Journal of Pharmacology and Experimental Therapeutics.
[150] Eric J. Nestler,et al. The molecular neurobiology of depression , 2008, Nature.
[151] D. Prasad,et al. Hypoxia‐induced deactivation of NGF‐mediated ERK1/2 signaling in hippocampal cells: Neuroprotection by acetyl‐L‐carnitine , 2008, Journal of neuroscience research.
[152] T. Schachtman,et al. MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats , 2008, Behavioural Brain Research.
[153] M. Furey,et al. Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression , 2008, Brain Structure and Function.
[154] Henrik Walter,et al. Gray matter reduction associated with psychopathology and cognitive dysfunction in unipolar depression: a voxel-based morphometry study. , 2008, Journal of affective disorders.
[155] Graeme Milligan,et al. Identification of a serotonin/glutamate receptor complex implicated in psychosis , 2008, Nature.
[156] S. Chaki,et al. Mood disorders: regulation by metabotropic glutamate receptors. , 2008, Biochemical pharmacology.
[157] V. Kaushal,et al. Mechanisms of Microglia-Mediated Neurotoxicity in a New Model of the Stroke Penumbra , 2008, The Journal of Neuroscience.
[158] Paul J. Harrison,et al. Expression of a GRM3 Splice Variant is Increased in the Dorsolateral Prefrontal Cortex of Individuals Carrying a Schizophrenia Risk SNP , 2008, Neuropsychopharmacology.
[159] W. Maier,et al. DNA sequence variants in the metabotropic glutamate receptor 3 and risk to schizophrenia: an association study , 2008, Psychiatric genetics.
[160] J. Bishop,et al. Association analysis of the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia. , 2007, Psychiatric genetics.
[161] O. Combarros,et al. Serum levels and genetic variation of TGF‐β1 are not associated with Alzheimer’s disease , 2007, Acta neurologica Scandinavica.
[162] Beng-Choon Ho,et al. MRI brain volume abnormalities in young, nonpsychotic relatives of schizophrenia probands are associated with subsequent prodromal symptoms , 2007, Schizophrenia Research.
[163] B. Moghaddam,et al. NMDA Receptor Hypofunction Produces Opposite Effects on Prefrontal Cortex Interneurons and Pyramidal Neurons , 2007, The Journal of Neuroscience.
[164] L. Crepaldi,et al. Altered Dimerization of Metabotropic Glutamate Receptor 3 in Schizophrenia , 2007, Biological Psychiatry.
[165] B. Moghaddam,et al. Positive Allosteric Modulation of Metabotropic Glutamate 5 (mGlu5) Receptors Reverses N-Methyl-D-Aspartate Antagonist-Induced Alteration of Neuronal Firing in Prefrontal Cortex , 2007, Biological Psychiatry.
[166] G. Annoni,et al. +10 T/C polymorphisms in the gene of transforming growth factor-β1 are associated with neurodegeneration and its clinical evolution , 2007, Mechanisms of Ageing and Development.
[167] Ravi S. Menon,et al. Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia , 2007, British Journal of Psychiatry.
[168] Timothy Edward John Behrens,et al. Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia. , 2007, Brain : a journal of neurology.
[169] F. Fornai,et al. Noradrenaline in Parkinson's disease: from disease progression to current therapeutics. , 2007, Current medicinal chemistry.
[170] F. Nicoletti,et al. The Use of Knock-Out Mice Unravels Distinct Roles for mGlu2 and mGlu3 Metabotropic Glutamate Receptors in Mechanisms of Neurodegeneration/Neuroprotection , 2007, The Journal of Neuroscience.
[171] W. Danysz,et al. Antagonism of metabotropic glutamate receptor type 5 attenuates l‐DOPA‐induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson’s disease , 2007, Journal of neurochemistry.
[172] John G. Csernansky,et al. Neurodegeneration in Schizophrenia: Evidence from In Vivo Neuroimaging Studies , 2007, TheScientificWorldJournal.
[173] L. Mucke,et al. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. , 2006, The Journal of clinical investigation.
[174] T. Golde,et al. Dysfunction of TGF- signaling in Alzheimers disease , 2006 .
[175] Sergio Montes,et al. Possible Mechanisms of Neurodegeneration in Schizophrenia , 2006, Neurochemical Research.
[176] A. Hofman,et al. Polymorphisms in the interleukin 6 and transforming growth factor β1 gene and risk of dementia The Rotterdam Study , 2006, Neuroscience Letters.
[177] F. Nicoletti,et al. Pharmacological Activation of mGlu4 Metabotropic Glutamate Receptors Reduces Nigrostriatal Degeneration in Mice Treated with 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine , 2006, The Journal of Neuroscience.
[178] P. Calabresi,et al. Acetyl-l-carnitine protects striatal neurons against in vitro ischemia: The role of endogenous acetylcholine , 2006, Neuropharmacology.
[179] E. Smeraldi,et al. A double-blind, randomised, controlled clinical trial of acetyl-l-carnitine vs. amisulpride in the treatment of dysthymia , 2006, European Neuropsychopharmacology.
[180] P. Bramanti,et al. Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease , 2006, Neurobiology of Disease.
[181] G. MacQueen,et al. An update on regional brain volume differences associated with mood disorders , 2006, Current opinion in psychiatry.
[182] M. Amalric,et al. Dysfunction of the cortico‐basal ganglia‐cortical loop in a rat model of early parkinsonism is reversed by metabotropic glutamate receptor 5 antagonism , 2005, The European journal of neuroscience.
[183] R. Perry,et al. Association studies of transforming growth factor‐β1 and Alzheimer's disease , 2005 .
[184] P. Jeffrey Conn,et al. Metabotropic glutamate receptors in the basal ganglia motor circuit , 2005, Nature Reviews Neuroscience.
[185] Vicki L. Ellingrod,et al. Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatment , 2005, Schizophrenia Research.
[186] R. Rosenthal,et al. Mechanisms of Ischemic Neuroprotection by Acetyl‐l‐carnitine , 2005, Annals of the New York Academy of Sciences.
[187] Nora Turjanski,et al. Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system. , 2005, Brain : a journal of neurology.
[188] M. Owen,et al. No evidence for association between polymorphisms in GRM3 and schizophrenia , 2005, BMC psychiatry.
[189] C. Lindsley,et al. A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models , 2005, Journal of Pharmacology and Experimental Therapeutics.
[190] Deanna L. Taylor,et al. Stimulation of Microglial Metabotropic Glutamate Receptor mGlu2 Triggers Tumor Necrosis Factor α-Induced Neurotoxicity in Concert with Microglial-Derived Fas Ligand , 2005, The Journal of Neuroscience.
[191] W. Spooren,et al. The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison , 2005, Psychopharmacology.
[192] M. Amalric,et al. Functional interaction between mGlu 5 and NMDA receptors in a rat model of Parkinson’s disease , 2005, Psychopharmacology.
[193] E. Nisenbaum,et al. Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s) , 2005, Psychopharmacology.
[194] G. He,et al. A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population , 2005, Schizophrenia Research.
[195] James C. Overholser,et al. Cellular changes in the postmortem hippocampus in major depression , 2004, Biological Psychiatry.
[196] R. Gibbs,et al. Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[197] S. Nakanishi,et al. Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent , 2004, Neuropharmacology.
[198] Michael Marriott,et al. Lower hippocampal volume in patients suffering from depression: a meta-analysis. , 2004, The American journal of psychiatry.
[199] M. Amalric,et al. Simultaneous Blockade of Adenosine A2A and Metabotropic Glutamate mGlu5 Receptors Increase their Efficacy in Reversing Parkinsonian Deficits in Rats , 2004, Neuropsychopharmacology.
[200] S. Nakanishi,et al. MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity , 2004, Neuropharmacology.
[201] Hyoung-Gon Lee,et al. Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer’s disease , 2004, Acta Neuropathologica.
[202] Giuseppe Battaglia,et al. Endogenous Activation of mGlu5 Metabotropic Glutamate Receptors Contributes to the Development of Nigro-Striatal Damage Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice , 2004, The Journal of Neuroscience.
[203] A. Dilella,et al. Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[204] M. Amalric,et al. Metabotropic Glutamate 5 Receptor Blockade Alleviates Akinesia by Normalizing Activity of Selective Basal-Ganglia Structures in Parkinsonian Rats , 2003, The Journal of Neuroscience.
[205] P Jeffrey Conn,et al. Group III Metabotropic Glutamate Receptor-Mediated Modulation of the Striatopallidal Synapse , 2003, The Journal of Neuroscience.
[206] F. Nicoletti,et al. Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice , 2003, Neuropharmacology.
[207] D. Lorrain,et al. Group II mGlu Receptor Activation Suppresses Norepinephrine Release in the Ventral Hippocampus and Locomotor Responses to Acute Ketamine Challenge , 2003, Neuropsychopharmacology.
[208] Y. Fukumaki,et al. Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia , 2003, Psychiatric genetics.
[209] J. Jankovic,et al. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD , 2003, Neurology.
[210] P. Renshaw,et al. Smaller frontal lobe white matter volumes in depressed adolescents , 2002, Biological Psychiatry.
[211] M. O'Neill,et al. Evaluation of the mGluR2/3 agonist LY379268 in rodent models of Parkinson's disease , 2002, Pharmacology Biochemistry and Behavior.
[212] G. Christoffersen,et al. Differential effects of mGluR1 and mGlur5 antagonism on spatial learning in rats , 2002, Pharmacology Biochemistry and Behavior.
[213] M. Cuzner,et al. Activation of group II metabotropic glutamate receptors underlies microglial reactivity and neurotoxicity following stimulation with chromogranin A, a peptide up‐regulated in Alzheimer's disease , 2002, Journal of neurochemistry.
[214] G. Nowak,et al. Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats , 2002, Neuropharmacology.
[215] M. Amalric,et al. Chronic But Not Acute Treatment with a Metabotropic Glutamate 5 Receptor Antagonist Reverses the Akinetic Deficits in a Rat Model of Parkinsonism , 2002, The Journal of Neuroscience.
[216] D. Mann,et al. Association study of three polymorphisms of TGF-β1 gene with Alzheimer's disease , 2002, Journal of neurology, neurosurgery, and psychiatry.
[217] F. Nicoletti,et al. Selective Blockade of mGlu5 Metabotropic Glutamate Receptors Is Protective against Methamphetamine Neurotoxicity , 2002, The Journal of Neuroscience.
[218] G Bernardi,et al. Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons , 2001, Neuroscience.
[219] F. Nicoletti,et al. Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective Drugs , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[220] S. Traynelis,et al. Metabotropic Glutamate Receptors 1 and 5 Differentially Regulate CA1 Pyramidal Cell Function , 2001, The Journal of Neuroscience.
[221] F. Moroni,et al. Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges , 2001, British journal of pharmacology.
[222] Y. Smith,et al. Activation of Metabotropic Glutamate Receptor 5 Has Direct Excitatory Effects and Potentiates NMDA Receptor Currents in Neurons of the Subthalamic Nucleus , 2000, The Journal of Neuroscience.
[223] S. DeKosky,et al. Analysis of genetic polymorphisms in the transforming growth factor-β1 gene and the risk of Alzheimer's disease , 2000, Human Genetics.
[224] G. Aghajanian,et al. Serotonin model of schizophrenia: emerging role of glutamate mechanisms , 2000, Brain Research Reviews.
[225] F. Nicoletti,et al. Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection , 1999, Neuropharmacology.
[226] P. Worley,et al. Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins , 1999, Neuron.
[227] F. Nicoletti,et al. Neuroprotection by Glial Metabotropic Glutamate Receptors Is Mediated by Transforming Growth Factor-β , 1998, The Journal of Neuroscience.
[228] B. Moghaddam,et al. Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. , 1998, Science.
[229] F. Bordi,et al. Potentiation of NMDA and AMPA responses by group I mGluR in spinal cord motoneurons , 1997, Neuropharmacology.
[230] F. Nicoletti,et al. The Neuroprotective Activity of Group-II Metabotropic Glutamate Receptors Requires New Protein Synthesis and Involves a Glial–Neuronal Signaling , 1997, The Journal of Neuroscience.
[231] G. Collingridge,et al. (RS)-2-Chloro-5-Hydroxyphenylglycine (CHPG) Activates mGlu5, but not mGlu1, Receptors Expressed in CHO Cells and Potentiates NMDA Responses in the Hippocampus , 1997, Neuropharmacology.
[232] F. Nicoletti,et al. Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? , 1996, Trends in Neurosciences.
[233] D. Schoepp,et al. (1S,3R)‐1‐Aminocyclopentane‐1,3‐Dicarboxylic Acid‐Induced Increases in Cyclic AMP Formation in the Neonatal Rat Hippocampus Are Mediated by a Synergistic Interaction Between Phosphoinositide‐ and Inhibitory Cyclic AMP‐Coupled mGluRs , 1996, Journal of neurochemistry.
[234] B. Hoffer,et al. Functional recovery in parkinsonian monkeys treated with GDNF , 1996, Nature.
[235] P. Sarzi-Puttini,et al. A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients: preliminary data. , 2015, Clinical and experimental rheumatology.
[236] P. Jeffrey Conn,et al. Development of allosteric modulators of GPCRs for treatment of CNS disorders , 2014, Neurobiology of Disease.
[237] M. Cenci,et al. Investigating the molecular mechanisms of L-DOPA-induced dyskinesia in the mouse. , 2014, Parkinsonism & related disorders.
[238] J. Pandit,et al. Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks. , 2013, Current topics in medicinal chemistry.
[239] F. Blandini,et al. A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease , 2013, Journal of Neural Transmission.
[240] P. Conn,et al. Emerging approaches for treatment of schizophrenia: modulation of glutamatergic signaling. , 2012, Discovery medicine.
[241] Bita Moghaddam,et al. From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment , 2012, Neuropsychopharmacology.
[242] L. Monteggia,et al. Brain-derived neurotrophic factor and neuropsychiatric disorders. , 2012, Pharmacological reviews.
[243] M. Cenci. L-DOPA-induced dyskinesia: cellular mechanisms and approaches to treatment. , 2007, Parkinsonism & related disorders.
[244] H. Car,et al. Effect of MPEP in Morris water maze in adult and old rats. , 2007, Pharmacological reports : PR.
[245] T. Golde,et al. Dysfunction of TGF-beta signaling in Alzheimer's disease. , 2006, The Journal of clinical investigation.
[246] R. Go,et al. Association studies of transforming growth factor-beta 1 and Alzheimer's disease. , 2005, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
[247] H. Holcomb,et al. Phenotype of schizophrenia: a review and formulation , 2005, Molecular Psychiatry.
[248] G. Aghajanian,et al. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. , 2000, The Journal of pharmacology and experimental therapeutics.