A rapid thermal method for cocrystal screening

A compound-sparing, automated and ‘green’ differential scanning calorimetric method was developed for rapid cocrystal screening.

[1]  W. Motherwell,et al.  Physical stability enhancement of theophylline via cocrystallization. , 2006, International journal of pharmaceutics.

[2]  Geoff G. Z. Zhang,et al.  Efficient co-crystal screening using solution-mediated phase transformation. , 2007, Journal of pharmaceutical sciences.

[3]  J. Sangster.  Phase Diagrams and Thermodynamic Properties of Binary Systems of Drugs , 1999 .

[4]  Aeri Park,et al.  The salt-cocrystal continuum: the influence of crystal structure on ionization state. , 2007, Molecular pharmaceutics.

[5]  W. Jones,et al.  Crystal Engineering of Organic Cocrystals by the Solid-State Grinding Approach , 2005 .

[6]  T. Friščić,et al.  Screening for pharmaceutical cocrystal hydrates via neat and liquid-assisted grinding. , 2007, Molecular pharmaceutics.

[7]  William Jones,et al.  Solvent-drop grinding: green polymorph control of cocrystallisation. , 2004, Chemical communications.

[8]  J. Ulrich.  Is Melt Crystallization a Green Technology , 2004 .

[9]  Sarah J. Nehm,et al.  Phase solubility diagrams of cocrystals are explained by solubility product and solution complexation , 2006 .

[10]  Sarah J. Nehm,et al.  Reaction crystallization of pharmaceutical molecular complexes. , 2006, Molecular pharmaceutics.

[11]  William Jones,et al.  Pharmaceutical Cocrystallization: Engineering a Remedy for Caffeine Hydration , 2005 .

[12]  Aeri Park,et al.  Use of a Glutaric Acid Cocrystal to Improve Oral Bioavailability of a Low Solubility API , 2006, Pharmaceutical Research.