Callosal connections of the posterior neocortex in normal‐eyed, congenitally anophthalmic, and neonatally enucleated mice

Following multiple injections of horseradish peroxidase into the posterior neocortex of one hemisphere, we examined the distribution of retrogradely labeled cells and anterogradely labeled terminations in tangential and coronal sections through contralateral areas 17 and 18 in throe groups of adult mice: normal‐eyed (ZRDCT‐n and C57Bl/6J strains), congenitally anophthalmic (ZRDCT‐an strain), and neonatally enucleated (ZRDCT‐n strain). In agreement with previous studies, we observed that the pattern of callosal connections in areas 17 and 18 of normal‐eyed mice contains the following features: (1) a dense band of callosal cells and terminations separating the interiors of areas 17 and 18, which have relatively few callosal connections, (2) a ring‐like configuration anterolateral to area 17, (3) a region of dense labeling lateral to area 18, (4) a narrow band of labeling bridging the posterior portion of area 18, and (5) a region of labeling anteromedial to area 17.

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