Humanized xenobiotic response in mice expressing nuclear receptor SXR

[1]  K. Griffin,et al.  Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors. , 1999, Molecular pharmacology.

[2]  D. Nelson,et al.  Cytochrome P450 and the individuality of species. , 1999, Archives of biochemistry and biophysics.

[3]  D. Waxman,et al.  P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. , 1999, Archives of biochemistry and biophysics.

[4]  A. Paterson,et al.  Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice , 1999, Oncogene.

[5]  W. Sabbagh,et al.  SXR, a novel steroid and xenobiotic-sensing nuclear receptor. , 1998, Genes & development.

[6]  R. Evans,et al.  Orphan nuclear receptors--new ligands and new possibilities. , 1998, Genes & development.

[7]  R Ohlsson,et al.  Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[8]  J. Lehmann,et al.  The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. , 1998, The Journal of clinical investigation.

[9]  J. Lehmann,et al.  An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway , 1998, Cell.

[10]  R. Tukey,et al.  Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. , 1996, Molecular pharmacology.

[11]  M. Relling,et al.  P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[12]  T. Kohzuma,et al.  Spectroscopic and Electrochemical Studies on Active-site Transitions of the Type 1 Copper Protein Pseudoazurin from Achromobacter cycloclastes(*) , 1995, The Journal of Biological Chemistry.

[13]  M. Denison,et al.  Xenobiotic-inducible Transcription of Cytochrome P450 Genes (*) , 1995, The Journal of Biological Chemistry.

[14]  J. Kolars,et al.  Aflatoxin B1-adduct formation in rat and human small bowel enterocytes. , 1994, Gastroenterology.

[15]  S. Tagawa,et al.  Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control. , 1993, European journal of biochemistry.

[16]  L. Benet,et al.  Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction , 1992, Clinical pharmacology and therapeutics.

[17]  J. Kolars,et al.  Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes. , 1992, The Journal of clinical investigation.

[18]  T. Kamataki,et al.  Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone. , 1992, Biochimica et biophysica acta.

[19]  E. Schuetz,et al.  Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[20]  C. Slaughter,et al.  Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. , 1990, The Journal of biological chemistry.

[21]  S. Ho,et al.  Site-directed mutagenesis by overlap extension using the polymerase chain reaction. , 1989, Gene.

[22]  R. Palmiter,et al.  An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. , 1987, Genes & development.

[23]  T. Self,et al.  Update on rifampin drug interactions. , 1987, Archives of internal medicine.

[24]  P. Watkins,et al.  Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat. , 1985, Molecular pharmacology.

[25]  D. Nebert,et al.  Mouse cytochrome P3-450: complete cDNA and amino acid sequence. , 1984, Nucleic acids research.

[26]  E. Schuetz,et al.  Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism. , 1984, The Journal of biological chemistry.

[27]  H. Selye.  Hormones and resistance. , 1970, Journal of pharmaceutical sciences.

[28]  L. Moore,et al.  The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. , 2000, Molecular endocrinology.

[29]  T. Self,et al.  Update on rifampin drug interactions. II. , 1992, Archives of internal medicine.

[30]  F. Gonzalez,et al.  Human cytochromes P450: problems and prospects. , 1992, Trends in pharmacological sciences.

[31]  F. Gonzalez,et al.  Molecular genetics of the P-450 superfamily. , 1990, Pharmacology & therapeutics.