Multimodal Optical Biopsy and Imaging of Skin Cancer

Abstract In this chapter, we present results of optical imaging of normal and malignant skin tissues with tumor detection by different techniques, including fluorescence analysis in visible and near infrared (NIR) regions, Raman spectroscopy, optical coherence tomography, and hyperspectral imaging. A comparison of the considered optical modalities, their limitations, and capabilities to detect skin cancer are discussed. The advantages of joint multimodal skin tissues are analyzed to reveal possibilities for precise malignant and nonmalignant tumors classification and tumor boundary detection. It is shown that the multimodal approach increases the sensitivity and specificity of skin cancer detection up to 97%.

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