Histopathology of primary pulmonary hypertension.

Table 1 summarizes the results of five large pathology series published during the past 20 years. The great majority of patients with PPH had wide­ spread abnormalities only in the arterial side of the pulmonary circulation at autopsy or lung biopsy and were classified as having pulmonary hypertensive arteriopathy. In a small percentage of cases, the hypertensive changes did involve primarily the venous pulmonary circulation, and the patients were classi­ fied as having pulmonary veno-ocelusive disease. In some cases, the diagnosis of PPH could not be confirmed histopathologically.

[1]  B. Groves,et al.  An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. , 1992, The New England journal of medicine.

[2]  S. Rich,et al.  The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. , 1992, The New England journal of medicine.

[3]  H. Palevsky,et al.  Primary pulmonary hypertension in association with human immunodeficiency virus infection. A possible viral etiology for some forms of hypertensive pulmonary arteriopathy. , 1992, The American review of respiratory disease.

[4]  R. Virmani,et al.  The pathology of primary pulmonary hypertension. , 1991, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[5]  M. Sherrid,et al.  Primary pulmonary hypertension associated with human immunodeficiency viral infection. , 1990 .

[6]  B. Groves,et al.  Histopathology of primary pulmonary hypertension. A qualitative and quantitative study of pulmonary blood vessels from 58 patients in the National Heart, Lung, and Blood Institute, Primary Pulmonary Hypertension Registry. , 1989, Circulation.

[7]  R. Virmani,et al.  Heterogeneity of pathologic lesions in familial primary pulmonary hypertension. , 1988, The American review of respiratory disease.

[8]  J. Rouleau,et al.  Familial pulmonary capillary hemangiomatosis resulting in primary pulmonary hypertension. , 1988, Annals of internal medicine.

[9]  G. Pietra,et al.  Specificity of pulmonary vascular lesions in primary pulmonary hypertension. A reappraisal. , 1987, Respiration; international review of thoracic diseases.

[10]  B. Brundage,et al.  Primary pulmonary hypertension: radiographic and scintigraphic patterns of histologic subtypes. , 1986, Annals of internal medicine.

[11]  T. Colby,et al.  Pulmonary capillary hemangiomatosis. , 1985, The American review of respiratory disease.

[12]  D. Heath,et al.  Pathologic Study of Unexplained Pulmonary Hypertension , 1985 .

[13]  T. Takahashi,et al.  Pulmonary veno-occlusive disease: involvement of pulmonary arteries and review of the literature. , 1985, Human pathology.

[14]  W. Edwards,et al.  Primary pulmonary hypertension: a histopathologic study of 80 cases. , 1985, Mayo Clinic proceedings.

[15]  V. Fuster,et al.  Primary pulmonary hypertension: natural history and the importance of thrombosis. , 1984, Circulation.

[16]  B. Chaitman,et al.  An epidemic of pulmonary hypertension after toxic rapeseed oil ingestion in Spain. , 1983, Journal of the American College of Cardiology.

[17]  M. Warnock,et al.  Pulmonary veno-occlusive disease after chemotherapy. , 1983, Human pathology.

[18]  L. Reid,et al.  Pulmonary veno-occlusive disease in siblings: case reports and morphometric study. , 1982, Human Pathology.

[19]  C. Wagenvoort.  Lung biopsy specimens in the evaluation of pulmonary vascular disease. , 1980, Chest.

[20]  J. Spijker,et al.  Capillary haemangiomatosis of the lungs , 1978, Histopathology.

[21]  C. Wagenvoort,et al.  Primary Pulmonary Hypertension: A Pathologic Study of the Lung Vessels in 156 Clinically Diagnosed Cases , 1970 .