The depressant scorpion neurotoxin LqqIT2 selectively modulates the insect voltage-gated sodium channel.

[1]  S. Heinemann,et al.  Isolation, molecular cloning and functional characterization of a novel beta-toxin from the Venezuelan scorpion, Tityus zulianus. , 2004, Toxicon : official journal of the International Society on Toxinology.

[2]  G. Nicolás,et al.  Conversion of a scorpion toxin agonist into an antagonist highlights an acidic residue involved in voltage sensor trapping during activation of neuronal Na+ channels , 2004 .

[3]  Michel De Waard,et al.  Diversity of folds in animal toxins acting on ion channels. , 2004, The Biochemical journal.

[4]  O. Froy,et al.  Dissection of the Functional Surface of an Anti-insect Excitatory Toxin Illuminates a Putative “Hot Spot” Common to All Scorpion β-Toxins Affecting Na+ Channels* , 2004, Journal of Biological Chemistry.

[5]  M. Benveniste,et al.  An 'Old World' scorpion beta-toxin that recognizes both insect and mammalian sodium channels. , 2003, European journal of biochemistry.

[6]  B. Hammock,et al.  Further enhancement of baculovirus insecticidal efficacy with scorpion toxins that interact cooperatively , 2003, FEBS Letters.

[7]  H. Karoui,et al.  BotIT6: a potent depressant insect toxin from Buthus occitanus tunetanus venom. , 2003, Toxicon : official journal of the International Society on Toxinology.

[8]  C. Chi,et al.  Purification of two depressant insect neurotoxins and their gene cloning from the scorpion Buthus martensi Karsch. , 2003, The journal of peptide research : official journal of the American Peptide Society.

[9]  J. Tytgat,et al.  The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect‐selective toxins , 2002, FEBS letters.

[10]  Hui Liu,et al.  Molecular cloning and functional expression of a gene encoding an antiarrhythmia peptide derived from the scorpion toxin. , 2002, European journal of biochemistry.

[11]  Jan Tytgat,et al.  An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch. , 2002, Toxicon : official journal of the International Society on Toxinology.

[12]  P. Usherwood,et al.  The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels. , 2001, Pest management science.

[13]  J. G. Grossmann,et al.  Purification, characterization, and primary structure of four depressant insect-selective neurotoxin analogs from scorpion (Buthus sindicus) venom. , 2001, Archives of biochemistry and biophysics.

[14]  O. Froy,et al.  Diversification of neurotoxins by C‐tail ‘wiggling’: a scorpion recipe for survival , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[15]  M. Stankiewicz,et al.  Electrophysiological analysis of the neurotoxic action of a funnel-web spider toxin, delta-atracotoxin-HV1a, on insect voltage-gated Na+ channels. , 2001, The Journal of experimental biology.

[16]  S. Cannon.  Voltage-gated ion channelopathies of the nervous system , 2001, Clinical Neuroscience Research.

[17]  M. Mevissen,et al.  Structure, function and pharmacology of voltage-gated sodium channels , 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

[18]  Yong-hua Ji,et al.  The binding of BmK IT2, a depressant insect-selective scorpion toxin on mammal and insect sodium channels , 2000, Neuroscience Research.

[19]  W. Catterall,et al.  Molecular mechanisms of neurotoxin action on voltage-gated sodium channels. , 2000, Biochimie.

[20]  M. Elazar,et al.  AaIT: from neurotoxin to insecticide. , 2000, Biochimie.

[21]  W. Catterall,et al.  From Ionic Currents to Molecular Mechanisms The Structure and Function of Voltage-Gated Sodium Channels , 2000, Neuron.

[22]  E. Stevens,et al.  Tissue distribution and functional expression of the human voltage-gated sodium channel β3 subunit , 2000, Pflügers Archiv.

[23]  W. Weber,et al.  Ion currents of Xenopus laevis oocytes: state of the art. , 1999, Biochimica et biophysica acta.

[24]  M. Delepierre,et al.  Scorpion toxins specific for Na+-channels. , 1999, European journal of biochemistry.

[25]  Oren Froy,et al.  The Putative Bioactive Surface of Insect-selective Scorpion Excitatory Neurotoxins* , 1999, The Journal of Biological Chemistry.

[26]  E. Zlotkin.  The insect voltage-gated sodium channel as target of insecticides. , 1999, Annual review of entomology.

[27]  W. Catterall,et al.  Voltage Sensor–Trapping Enhanced Activation of Sodium Channels by β-Scorpion Toxin Bound to the S3–S4 Loop in Domain II , 1998, Neuron.

[28]  B. Hammock,et al.  A depressant insect-selective toxin analog from the venom of the scorpion Leiurus quinquestriatus hebraeus--purification and structure/function characterization. , 1998, European journal of biochemistry.

[29]  S. Zinn-Justin,et al.  Functional Anatomy of Scorpion Toxins Affecting Sodium Channels , 1998 .

[30]  R. Reenan,et al.  Functional Expression of Drosophila para Sodium Channels Modulation by the Membrane Protein TipE and Toxin Pharmacology , 1997 .

[31]  M. Gurevitz,et al.  Refined electrophysiological analysis suggests that a depressant toxin is a sodium channel opener rather than a blocker. , 1997, Life sciences.

[32]  E. Carlier,et al.  Scorpion Toxins Affecting Sodium Current Inactivation Bind to Distinct Homologous Receptor Sites on Rat Brain and Insect Sodium Channels (*) , 1996, The Journal of Biological Chemistry.

[33]  P. Deák,et al.  Cloning and functional analysis of tipE, a novel membrane protein that enhances drosophila para sodium channel function , 1995, Cell.

[34]  J. Tytgat,et al.  Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs , 1992, Neuron.

[35]  S. Volrath,et al.  Insecticidal effects of an insect-specific neurotoxin expressed by a recombinant baculovirus. , 1991, Virology.

[36]  R. Possee,et al.  Construction of an improved baculovirus insecticide containing an insect-specific toxin gene , 1991, Nature.

[37]  V. Bindokas,et al.  Functional duality and structural uniqueness of depressant insect-selective neurotoxins. , 1991, Biochemistry.

[38]  H. Rochat,et al.  On the binding of two scorpion toxins to the central nervous system of the cockroach Periplaneta americana , 1989 .

[39]  H. Rochat,et al.  Tityus serrulatus toxin VII bears pharmacological properties of both beta-toxin and insect toxin from scorpion venoms. , 1986, Biochemical and biophysical research communications.

[40]  H. Takeshima,et al.  Existence of distinct sodium channel messenger RNAs in rat brain , 1986, Nature.

[41]  D. Kadouri,et al.  An excitatory and a depressant insect toxin from scorpion venom both affect sodium conductance and possess a common binding site. , 1985, Archives of biochemistry and biophysics.

[42]  E. Zlotkin,et al.  Actions of insect toxin and other toxins derived from the venom of the scorpion Androctonus australis on isolated giant axons of the cockroach (Periplaneta americana). , 1982, The Journal of experimental biology.

[43]  H. Rochat,et al.  Two types of scorpion receptor sites, one related to the activation, the other to the inactivation of the action potential sodium channel. , 1982, Toxicon : official journal of the International Society on Toxinology.

[44]  M. Cahalan.  Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venom. , 1975, The Journal of physiology.

[45]  B. Hille.  The Permeability of the Sodium Channel to Organic Cations in Myelinated Nerve , 1971, The Journal of general physiology.