The clinical potential of exhaled breath analysis for diabetes mellitus.

[1]  M. Epton,et al.  Measurement of breath acetone concentrations by selected ion flow tube mass spectrometry in type 2 Diabetes , 2011, Journal of breath research.

[2]  D. Blake,et al.  Gas Signatures from Cultured Neutrophils and Peripheral Blood Mononuclear Cells Obtained from Healthy Humans , 2011 .

[3]  David Smith,et al.  Breath acetone concentration; biological variability and the influence of diet , 2011, Physiological measurement.

[4]  G. Milne,et al.  Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes , 2011, Pediatric diabetes.

[5]  V. M. Gruznov,et al.  Concentration of light hydrocarbons in exhaled air depending on metabolic syndrome risk factors , 2011, Human Physiology.

[6]  Simone Meinardi,et al.  Noninvasive measurement of plasma glucose from exhaled breath in healthy and type 1 diabetic subjects. , 2011, American journal of physiology. Endocrinology and metabolism.

[7]  Claire Turner,et al.  Potential of breath and skin analysis for monitoring blood glucose concentration in diabetes , 2011, Expert review of molecular diagnostics.

[8]  David Smith,et al.  Can volatile compounds in exhaled breath be used to monitor control in diabetes mellitus? , 2011, Journal of breath research.

[9]  S. Cristoni,et al.  Secondary electrospray ionization-mass spectrometry: breath study on a control group , 2011, Journal of breath research.

[10]  E. Cummins,et al.  Regulation of gene expression by carbon dioxide , 2011, The Journal of physiology.

[11]  J. Eun,et al.  Identification of characteristic molecular signature for volatile organic compounds in peripheral blood of rat. , 2011, Toxicology and applied pharmacology.

[12]  Yaoyao Jia,et al.  Limonene, a natural cyclic terpene, is an agonistic ligand for adenosine A(2A) receptors. , 2011, Biochemical and biophysical research communications.

[13]  Julian King,et al.  A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone , 2010, Journal of mathematical biology.

[14]  J. Namieśnik,et al.  Isoprostanes-Biomarkers of Lipid Peroxidation: Their Utility in Evaluating Oxidative Stress and Analysis , 2010, International journal of molecular sciences.

[15]  W. Miekisch,et al.  Analysis of exhaled breath for screening of lung cancer patients , 2010 .

[16]  Julian King,et al.  Physiological modeling of isoprene dynamics in exhaled breath. , 2010, Journal of theoretical biology.

[17]  M. Leonard,et al.  NF-κB Links CO2 Sensing to Innate Immunity and Inflammation in Mammalian Cells , 2010, The Journal of Immunology.

[18]  M. Zeegers,et al.  Pulmonary function in diabetes: a metaanalysis. , 2010, Chest.

[19]  R. Dweik,et al.  Clinical applications of breath testing , 2010, F1000 medicine reports.

[20]  H. Paretzke,et al.  Differences in exhaled gas profiles between patients with type 2 diabetes and healthy controls. , 2010, Diabetes technology & therapeutics.

[21]  S. Vinogradov,et al.  Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier. , 2010, American journal of respiratory and critical care medicine.

[22]  Graham Bothamley,et al.  Breath biomarkers of active pulmonary tuberculosis. , 2010, Tuberculosis.

[23]  Anton Amann,et al.  TD-GC-MS Analysis of Volatile Metabolites of Human Lung Cancer and Normal Cells In vitro , 2010, Cancer Epidemiology, Biomarkers & Prevention.

[24]  M. Shepherd,et al.  A Study on Breath Acetone in Diabetic Patients Using a Cavity Ringdown Breath Analyzer: Exploring Correlations of Breath Acetone With Blood Glucose and Glycohemoglobin A1C , 2010, IEEE Sensors Journal.

[25]  A. Soro-Paavonen,et al.  AGE-RAGE signalling in endothelial dysfunction and atherosclerosis in diabetes , 2010 .

[26]  A. Karsan,et al.  Endothelial Dysfunction and Inflammation , 2010 .

[27]  N. Lee,et al.  Limonene suppresses lipopolysaccharide-induced production of nitric oxide, prostaglandin E2, and pro-inflammatory cytokines in RAW 264.7 macrophages. , 2010, Journal of oleo science.

[28]  J. Shaw,et al.  Global estimates of the prevalence of diabetes for 2010 and 2030. , 2010, Diabetes research and clinical practice.

[29]  David Smith,et al.  Quantification of acetaldehyde and carbon dioxide in the headspace of malignant and non-malignant lung cells in vitro by SIFT-MS. , 2009, The Analyst.

[30]  Hui Xu,et al.  Analysis of Hexanal and Heptanal in Human Blood by Simultaneous Derivatization and Dispersive Liquid–Liquid Microextraction then LC–APCI–MS–MS , 2009 .

[31]  D. Wink,et al.  Physiological and pharmacological features of the novel gasotransmitter: hydrogen sulfide. , 2009, Biochimica et biophysica acta.

[32]  D. Blake,et al.  Improved predictive models for plasma glucose estimation from multi-linear regression analysis of exhaled volatile organic compounds. , 2009, Journal of applied physiology.

[33]  Mika Kivimäki,et al.  Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study , 2009, The Lancet.

[34]  J. Holson,et al.  Methyl iodide-induced fetal hypothyroidism implicated in late-stage fetal death in rabbits , 2009, Inhalation toxicology.

[35]  Two-day inhalation toxicity study of methyl iodide in the rat , 2009, Inhalation toxicology.

[36]  M. Sheffield-Moore,et al.  Novel Noninvasive Breath Test Method for Screening Individuals at Risk for Diabetes , 2009, Diabetes Care.

[37]  Edgard Delvin,et al.  Continuous glucose monitoring: a review of biochemical perspectives and clinical use in type 1 diabetes. , 2009, Clinical biochemistry.

[38]  David Smith,et al.  Hydrogen cyanide as a biomarker for Pseudomonas aeruginosa in the breath of children with cystic fibrosis , 2009, Pediatric pulmonology.

[39]  D. Blake,et al.  Ethane and n-pentane in exhaled breath are biomarkers of exposure not effect , 2009, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[40]  M. Peck,et al.  SIGNAL TRANSDUCTION PATHWAYS LINKING THE ACTIVATION OF ALVEOLAR MACROPHAGES WITH THE RECRUITMENT OF NEUTROPHILS TO LUNGS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE , 2009, Experimental lung research.

[41]  Simone Meinardi,et al.  Journal of Translational Medicine BioMed Central Methodology , 2005 .

[42]  M. Quirynen,et al.  GC-MS analysis of breath odor compounds in liver patients. , 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[43]  J. Flores-Hernández,et al.  Diabetes induces pulmonary artery endothelial dysfunction by NADPH oxidase induction. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[44]  P. Martínez-Lozano,et al.  Direct analysis of fatty acid vapors in breath by electrospray ionization and atmospheric pressure ionization-mass spectrometry. , 2008, Analytical chemistry.

[45]  Arthur S Slutsky,et al.  Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases. , 2008, American journal of physiology. Heart and circulatory physiology.

[46]  Doni Hikmat Ramdhan,et al.  Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1. , 2008, Toxicology and applied pharmacology.

[47]  B. Fouty.  Diabetes and the pulmonary circulation. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[48]  L. Foubert,et al.  Dynamic Tight Glycemic Control During and After Cardiac Surgery Is Effective, Feasible, and Safe , 2008, Anesthesia and analgesia.

[49]  Hui-yu Liu,et al.  Suppression of Hepatic Glucose Production by Human Neutrophil α-Defensins through a Signaling Pathway Distinct from Insulin* , 2008, Journal of Biological Chemistry.

[50]  C. Forsblom,et al.  Increased levels of alpha-defensin (-1, -2 and -3) in type 1 diabetic patients with nephropathy. , 2008, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[51]  P. Moore,et al.  An overview of the biological significance of endogenous gases: new roles for old molecules. , 2007, Biochemical Society transactions.

[52]  C. Forsblom,et al.  Increased levels of α-defensin (-1, -2 and -3) in type 1 diabetic patients with nephropathy , 2007 .

[53]  D. Blake,et al.  Exhaled methyl nitrate as a noninvasive marker of hyperglycemia in type 1 diabetes , 2007, Proceedings of the National Academy of Sciences.

[54]  David Smith,et al.  Acetone, ammonia and hydrogen cyanide in exhaled breath of several volunteers aged 4–83 years , 2007, Journal of breath research.

[55]  Ping Wang,et al.  A study of the volatile organic compounds exhaled by lung cancer cells in vitro for breath diagnosis , 2007, Cancer.

[56]  A. Maran,et al.  Non-invasive glucose monitoring: assessment of technologies and devices according to quantitative criteria. , 2007, Diabetes research and clinical practice.

[57]  Bogusław Buszewski,et al.  Human exhaled air analytics: biomarkers of diseases. , 2007, Biomedical chromatography : BMC.

[58]  D. Baines,et al.  Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis. , 2007, Journal of applied physiology.

[59]  S. M. Aschmann,et al.  Pressure dependence of pentyl nitrate formation from the OH Radical-initiated reaction of n-pentane in the presence of NO. , 2006, The journal of physical chemistry. A.

[60]  David Smith,et al.  A longitudinal study of methanol in the exhaled breath of 30 healthy volunteers using selected ion flow tube mass spectrometry, SIFT-MS , 2006, Physiological measurement.

[61]  Olaf Tietje,et al.  Prediction of breast cancer using volatile biomarkers in the breath , 2006, Breast Cancer Research and Treatment.

[62]  N. Clark,et al.  Standards of Medical Care in Diabetes: Response to Power , 2006 .

[63]  A. Tabesh,et al.  Breath biomarkers and non-alcoholic fatty liver disease: Preliminary observations , 2006, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[64]  D. Blake,et al.  Breath sulfides and pulmonary function in cystic fibrosis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[65]  P. J. Barnes,et al.  Exhaled breath condensate: methodological recommendations and unresolved questions , 2005, European Respiratory Journal.

[66]  E. Blaak.  Metabolic fluxes in skeletal muscle in relation to obesity and insulin resistance. , 2005, Best practice & research. Clinical endocrinology & metabolism.

[67]  J. Stamler,et al.  A Novel Inhaled Organic Nitrate That Affects Pulmonary Vascular Tone in a Piglet Model of Hypoxia-Induced Pulmonary Hypertension , 2005, Pediatric Research.

[68]  Rossana Salerno-Kennedy,et al.  Potential applications of breath isoprene as a biomarker in modern medicine: a concise overview , 2005, Wiener klinische Wochenschrift.

[69]  Simone Meinardi,et al.  Breath ethanol and acetone as indicators of serum glucose levels: an initial report. , 2005, Diabetes technology & therapeutics.

[70]  A. Ceccarini,et al.  Breath analysis: trends in techniques and clinical applications , 2005 .

[71]  X. Zhang,et al.  Investigation of volatile biomarkers in lung cancer blood using solid-phase microextraction and capillary gas chromatography-mass spectrometry. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[72]  W. Miekisch,et al.  Diagnostic potential of breath analysis--focus on volatile organic compounds. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[73]  M. Phillips,et al.  Heart allograft rejection: detection with breath alkanes in low levels (the HARDBALL study). , 2004, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[74]  M. Phillips,et al.  Increased breath biomarkers of oxidative stress in diabetes mellitus. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[75]  P. Pencharz,et al.  A comparison of the metabolism of eighteen-carbon 13C-unsaturated fatty acids in healthy women Published, JLR Papers in Press, December 16, 2003. DOI 10.1194/jlr.M300304-JLR200 , 2004, Journal of Lipid Research.

[76]  Albert L. Babb,et al.  Modeling Soluble Gas Exchange in the Airways and Alveoli , 2003, Annals of Biomedical Engineering.

[77]  D. Kearney,et al.  Breath Ammonia Measurement in Helicobacter pylori Infection , 2002, Digestive Diseases and Sciences.

[78]  U. Keller,et al.  Effect of insulin on ketone body clearance studied by a ketone body “clamp” technique in normal man , 1988, Diabetologia.

[79]  J. F. Periago,et al.  Application of solid-phase microextraction and gas chromatography-mass spectrometry to the determination of volatile organic compounds in end-exhaled breath samples. , 2003, Journal of chromatography. A.

[80]  G. Verleden,et al.  Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma. , 2003, Chest.

[81]  S. Cunnane,et al.  Breath acetone is a reliable indicator of ketosis in adults consuming ketogenic meals. , 2002, The American journal of clinical nutrition.

[82]  B. Thomma,et al.  Plant defensins , 2002, Planta.

[83]  D. Blake,et al.  Description of the analysis of a wide range of volatile organic compounds in whole air samples collected during PEM-tropics A and B. , 2001, Analytical chemistry.

[84]  Isobel J. Simpson,et al.  Aircraft Measurements of Dimethyl Sulfide (DMS) Using a Whole Air Sampling Technique , 2001 .

[85]  K. Geiger,et al.  Analysis of volatile disease markers in blood. , 2001, Clinical chemistry.

[86]  W. Lindinger,et al.  Analysis of volatile organic compounds: possible applications in metabolic disorders and cancer screening. , 2001, Wiener klinische Wochenschrift.

[87]  S. Larsen,et al.  Effects of methacrolein on the respiratory tract in mice. , 2000, Toxicology letters.

[88]  J. Sehlin,et al.  The Glucose Concentration Modulates N-Formyl-Methionyl-Leucyl-Phenylalanine (fMet-Leu-Phe)-Stimulated Chemokinesis in Normal Human Neutrophils , 1999, Bioscience reports.

[89]  L. Laffel.  Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes , 1999, Diabetes/metabolism research and reviews.

[90]  P. Barnes,et al.  Exhaled carbon monoxide levels elevated in diabetes and correlated with glucose concentration in blood: a new test for monitoring the disease? , 1999, Chest.

[91]  M. Phillips,et al.  Variation in volatile organic compounds in the breath of normal humans. , 1999, Journal of chromatography. B, Biomedical sciences and applications.

[92]  R. Cataneo,et al.  Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study , 1999, The Lancet.

[93]  A. Jonckheere,et al.  Diabetes mellitus Induces a Thickening of the Pulmonary Basal Lamina , 1999, Respiration.

[94]  B. Thomma,et al.  Concomitant Activation of Jasmonate and Ethylene Response Pathways Is Required for Induction of a Plant Defensin Gene in Arabidopsis , 1998, Plant Cell.

[95]  J. Sheen,et al.  Glucose and ethylene signal transduction crosstalk revealed by an Arabidopsis glucose-insensitive mutant. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[96]  J. Sehlin,et al.  D-Glucose but Not Insulin Reduces N-formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe)-Induced Shape Changes in Suspended Human Neutrophils , 1997, Bioscience reports.

[97]  A. Hansel,et al.  Endogenous production of methanol after the consumption of fruit. , 1997, Alcoholism, clinical and experimental research.

[98]  M. Ramanathan,et al.  Antihyperglycemic activity of phenolics from Pterocarpus marsupium. , 1997, Journal of natural products.

[99]  K. Krishnan,et al.  A mechanistic algorithm for predicting blood:air partition coefficients of organic chemicals with the consideration of reversible binding in hemoglobin. , 1996, Toxicology and applied pharmacology.

[100]  C. Kneepkens,et al.  The potential of the hydrocarbon breath test as a measure of lipid peroxidation. , 1994, Free radical biology & medicine.

[101]  D. Ashley,et al.  Blood concentrations of volatile organic compounds in a nonoccupationally exposed US population and in groups with suspected exposure. , 1994, Clinical chemistry.

[102]  R. Devlin,et al.  Exposure of humans to a volatile organic mixture. III. Inflammatory response. , 1992, Archives of environmental health.

[103]  P. Sobotka,et al.  High breath pentane concentrations during acute myocardial infarction , 1991, The Lancet.

[104]  V. Basevi.  Standards of Medical Care in Diabetes—2011 , 2011, Diabetes Care.

[105]  E. Christ,et al.  The composition of alkanes in exhaled air of rats as a result of lipid peroxidation in vivo. Effects of dietary fatty acids, vitamin E and selenium. , 1981, Biochimica et biophysica acta.

[106]  I. Åstrand,et al.  Exposure to xylene and ethylbenzene. I. Uptake, distribution and elimination in man. , 1978, Scandinavian journal of work, environment & health.

[107]  L. Blendis,et al.  BREATH HYDROGEN AS A DIAGNOSTIC METHOD FOR HYPOLACTASIA , 1975, The Lancet.

[108]  A. B. Robinson,et al.  Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[109]  S. P. Burg,et al.  Ethylene Action and the Ripening of Fruits , 1965, Science.