Regular aspirin use and myocardial infarction.

We suggest that this man's acute rise in blood pressure was the result of his stopping methyldopa, which probably resulted in infarction of the medial longitudinal bundle. Supporting this supposition was his description of symptoms during times when he had previously stopped his treatment which were similar to those reported on clonidine withdrawal. We believe this case to be important because previously rebound hypertension has been reported only with clonidine. Possibly rebound hypertension is a more general property of hypotensive agents.