Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage
暂无分享,去创建一个
B. Moore | P. Qian | Wenjun Zhang | Jie Li | W. Cai | Weipeng Zhang | Jennifer Y. H. Lai | Shaun M. K. McKinnie | Zhong-Rui Li
[1] J. Crawford,et al. Structure elucidation of colibactin , 2019, bioRxiv.
[2] Paul D. Boudreau,et al. The reactivity of an unusual amidase may explain colibactin’s DNA cross-linking activity , 2019, bioRxiv.
[3] J. Arthur,et al. Revealing a microbial carcinogen , 2019, Science.
[4] Paul D. Boudreau,et al. The human gut bacterial genotoxin colibactin alkylates DNA , 2019, Science.
[5] G. Dalmasso,et al. Colibactin: More Than a New Bacterial Toxin , 2018, Toxins.
[6] F. Taieb,et al. The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells , 2018, mBio.
[7] P. Seed,et al. Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria. , 2018, ACS infectious diseases.
[8] J. Crawford,et al. ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance. , 2017, Journal of the American Chemical Society.
[9] C. Knauf,et al. Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917 , 2017, Nature Communications.
[10] J. Crawford,et al. Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway. , 2017, ACS chemical biology.
[11] N. Kelleher,et al. Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring , 2017, Nature chemical biology.
[12] A. Fodor,et al. Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis. , 2017, Cancer research.
[13] B. Moore,et al. Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin , 2016, Nature chemical biology.
[14] S. Ng,,et al. A new luminescent lanthanide supramolecular network possessing free Lewis base sites for highly selective and sensitive Cu^2+ sensing , 2016, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
[15] J. Crawford,et al. Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A. , 2016, Journal of the American Chemical Society.
[16] Sudhir Kumar,et al. MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. , 2016, Molecular biology and evolution.
[17] E. Balskus,et al. Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin. , 2016, ACS chemical biology.
[18] J. Nougayrède,et al. Escherichia coli ClbS is a colibactin resistance protein , 2016, Molecular microbiology.
[19] E. Paulson,et al. Structural basis for DNA cleavage by the potent antiproliferative agent (–)-lomaiviticin A , 2016, Proceedings of the National Academy of Sciences.
[20] E. Balskus. Colibactin: understanding an elusive gut bacterial genotoxin. , 2015, Natural product reports.
[21] H. Bode. The Microbes inside Us and the Race for Colibactin. , 2015, Angewandte Chemie.
[22] P. Qian,et al. Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway , 2015, Chembiochem : a European journal of chemical biology.
[23] R. Ueoka,et al. Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor. , 2015, Chemical communications.
[24] M. Fischbach,et al. Small molecules from the human microbiota , 2015, Science.
[25] J. Crawford,et al. The colibactin warhead crosslinks DNA , 2015, Nature chemistry.
[26] E. Balskus,et al. Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity. , 2015, Organic letters.
[27] Philipp Engel,et al. Gut Symbionts from Distinct Hosts Exhibit Genotoxic Activity via Divergent Colibactin Biosynthesis Pathways , 2014, Applied and Environmental Microbiology.
[28] Justine W. Debelius,et al. Specialized metabolites from the microbiome in health and disease. , 2014, Cell metabolism.
[29] Peter Cimermancic,et al. A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics , 2014, Cell.
[30] L. Urban,et al. Optimized Assay for Hydrogen Peroxide Determination in Plant Tissue Using Potassium Iodide , 2014 .
[31] Philipp Engel,et al. Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules , 2014, Journal of the American Chemical Society.
[32] P. Glazer,et al. The cytotoxicity of (–)-lomaiviticin A arises from induction of double-strand breaks in DNA , 2014, Nature chemistry.
[33] E. Denamur,et al. Maternally acquired genotoxic Escherichia coli alters offspring’s intestinal homeostasis , 2014, Gut microbes.
[34] G. Dalmasso,et al. Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype , 2014, Gut.
[35] Ascel Samba-Louaka,et al. Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells , 2013, PloS one.
[36] A. Stewart,et al. In Vivo Evidence for a Prodrug Activation Mechanism during Colibactin Maturation , 2013, Chembiochem : a European journal of chemical biology.
[37] M. Richter,et al. The genus Pseudovibrio contains metabolically versatile bacteria adapted for symbiosis , 2013, Environmental microbiology.
[38] E. Balskus,et al. A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicity. , 2013, Journal of the American Chemical Society.
[39] D. Pezet,et al. High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer , 2013, PloS one.
[40] Y. Pommier. Drugging topoisomerases: lessons and challenges. , 2013, ACS chemical biology.
[41] J. Derisi,et al. Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor. , 2012, Journal of the American Chemical Society.
[42] Belgin Dogan,et al. Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota , 2012, Science.
[43] U. Dobrindt,et al. Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity , 2012, Gut microbes.
[44] J. Crowley,et al. The siderophore yersiniabactin binds copper to protect pathogens during infection , 2012, Nature chemical biology.
[45] J. Nicholson,et al. Host-Gut Microbiota Metabolic Interactions , 2012, Science.
[46] M. Blaser,et al. The human microbiome: at the interface of health and disease , 2012, Nature Reviews Genetics.
[47] G. Evans. Lessons and Challenges , 2011 .
[48] Gabriel Cuevas-Ramos,et al. Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells , 2010, Proceedings of the National Academy of Sciences.
[49] G. Pratviel,et al. Activation of DNA carbon-hydrogen bonds by metal complexes. , 2010, Chemical reviews.
[50] D. Rudner,et al. SirA enforces diploidy by inhibiting the replication initiator DnaA during spore formation in Bacillus subtilis , 2009, Molecular microbiology.
[51] Michael Dourson,et al. Copper and Human Health: Biochemistry, Genetics, and Strategies for Modeling Dose-response Relationships , 2007, Journal of toxicology and environmental health. Part B, Critical reviews.
[52] N. Kelleher,et al. Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units , 2006, Proceedings of the National Academy of Sciences.
[53] Carmen Buchrieser,et al. Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells , 2006, Science.
[54] J. Stubbe,et al. Bleomycins: towards better therapeutics , 2005, Nature Reviews Cancer.
[55] A. Collins,et al. The comet assay for DNA damage and repair , 2004, Molecular biotechnology.
[56] J. H. Parish,et al. Strand scission in DNA induced by dietary flavonoids: role of Cu(I) and oxygen free radicals and biological consequences of scission , 1992, Molecular and Cellular Biochemistry.
[57] Nizam Uddin Khan,et al. Antioxidant and prooxidant properties of caffeine, theobromine and xanthine. , 2003, Medical science monitor : international medical journal of experimental and clinical research.
[58] G. Challis,et al. PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[59] F. Blattner,et al. Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[60] K. Karlin,et al. Oxidative strand scission of nucleic acids by a multinuclear copper(II) complex , 2002, JBIC Journal of Biological Inorganic Chemistry.
[61] K. Khanna,et al. DNA double-strand breaks: signaling, repair and the cancer connection , 2001, Nature Genetics.
[62] T. Halazonetis,et al. P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks , 2000, The Journal of cell biology.
[63] N. Lindquist,et al. Double-Strand DNA Cleavage by Copper·Prodigiosin , 2000 .
[64] B. Wanner,et al. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[65] S. Borah,et al. Copper-Mediated Nuclease Activity of a Tambjamine Alkaloid , 1998 .
[66] E. Rogakou,et al. DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139* , 1998, The Journal of Biological Chemistry.
[67] J. Stubbe,et al. Mechanisms of bleomycin-induced DNA degradation , 1987 .
[68] F. Bolivar,et al. Plasmid vector pBR322 and its special-purpose derivatives--a review. , 1986, Gene.
[69] S. Horwitz,et al. Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA. , 1981, The Journal of biological chemistry.
[70] J. Repine,et al. Dimethyl sulfoxide prevents DNA nicking mediated by ionizing radiation or iron/hydrogen peroxide-generated hydroxyl radical. , 1981, Proceedings of the National Academy of Sciences of the United States of America.
[71] L. Povirk,et al. DNA double-strand breaks and alkali-labile bonds produced by bleomycin. , 1977, Nucleic acids research.
[72] B. E. Trumbo,et al. Matching of single‐strand breaks to form double‐strand breaks in DNA , 1969 .
[73] Joel H. Hildebrand,et al. A Spectrophotometric Investigation of the Interaction of Iodine with Aromatic Hydrocarbons , 1949 .