Primary hepatoid adenocarcinoma of the uterine cervix

Hepatoid adenocarcinoma is characterized histologically by neoplastic epithelial cells that resemble hepatocellular carcinoma (HCC) and produce alpha-fetoprotein (AFP). We describe a case of hepatoid adenocarcinoma of the uterus that, unlike any other previously reported case, was strictly confined to the cervix. A cervical biopsy demonstrated poorly differentiated adenocarcinoma, and hysterectomy and bilateral salpingo-oophorectomy were subsequently performed. Histologically, the lesion consisted of solid sheets of hepatoid cells accompanied with areas of endometroid adenocarcinoma. The tumor cells showed strong and diffuse cytoplasmic immunoreactivity with AFP in both medullary and adenocarcinoma components. Metastases to bilateral pelvic lymph nodes were detected 12 months after surgery. Since undergoing total pelvic irradiation, the patient has been alive and in full remission for 22 months. To our knowledge, this is the first report of primary hepatoid adenocarcinoma of the uterine cervix.

[1]  M. Takano,et al.  Malignant mixed Mullerian tumor of the uterine corpus with alpha-fetoprotein-producing hepatoid adenocarcinoma component. , 2003, Gynecologic oncology.

[2]  Yoshihisa Takahashi,et al.  Hepatoid carcinoma of the uterus that collided with carcinosarcoma , 2003, Pathology international.

[3]  A. Montag,et al.  An α-Fetoprotein-Producing Hepatoid Adenocarcinoma of the Endometrium , 2001 .

[4]  A. Montag,et al.  An alpha-fetoprotein-producing hepatoid adenocarcinoma of the endometrium. , 2001, Gynecologic oncology.

[5]  H. Toyoda,et al.  Alpha‐fetoprotein producing uterine corpus carcinoma: A hepatoid adenocarcinoma of the endometrium , 2000, Pathology international.

[6]  H. Ishikura,et al.  Adenocarcinoma of the uterine cervix with choriocarcinomatous and hepatoid differentiation: report of a case. , 2000, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[7]  H. Mizuoka,et al.  An autopsy case of hepatoid carcinoma of the ovary with PIVKA‐II production: Immunohistochemical study and literature review , 1999, Pathology international.

[8]  O. Matsubara,et al.  Hepatoid carcinoma of the lung with production of alpha-fetoprotein and abnormal prothrombin: an autopsy case report. , 1997, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[9]  F. Collin,et al.  Hepatoid adenocarcinoma of the lung: report of a case of an unusual alpha-fetoprotein-producing lung tumor. , 1997, The American journal of surgical pathology.

[10]  T. Eimoto,et al.  α-fetoprotein-producing (hepatoid) carcinoma of the fallopian tube , 1996 .

[11]  K. Aozasa,et al.  Hepatoid adenocarcinoma of the endometrium associated with alpha-fetoprotein production. , 1996, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[12]  H. Ishikura,et al.  Alpha-fetoprotein production by a hepatoid adenocarcinoma of the uterus. , 1996, Journal of clinical pathology.

[13]  T. Eimoto,et al.  alpha-Fetoprotein-producing (hepatoid) carcinoma of the fallopian tube. , 1996, Gynecologic oncology.

[14]  J. Melamed,et al.  Hepatoid adenocarcinoma in the urinary bladder. Unusual localization of a newly recognized tumor type , 1994, Cancer.

[15]  T. Yoshiki,et al.  Hepatoid adenocarcinoma of the renal pelvis producing alpha‐fetoprotein of hepatic type and bile pigment , 1991, Cancer.

[16]  R. Scully,et al.  Hepatoid carcinoma of the ovary. A newly described tumor , 1987, Cancer.

[17]  M. Shamoto,et al.  Hepatoid adenocarcinomas of the stomach: An analysis of seven cases , 1986, Cancer.