Pharmaceutical treatment for cognitive deficits in Alzheimer’s disease and other neurodegenerative conditions: exploring new territory using traditional tools and established maps

[1]  M. Tuszynski,et al.  Therapeutic potential of CERE-110 (AAV2-NGF): Targeted, stable, and sustained NGF delivery and trophic activity on rodent basal forebrain cholinergic neurons , 2008, Experimental Neurology.

[2]  J. Haxby,et al.  Effects of long-term continuous infusion of the muscarinic cholinergic agonist arecoline on verbal memory in dementia of the Alzheimer type. , 1991, Psychopharmacology bulletin.

[3]  R. Martins,et al.  Precursor of Alzheimer’s Disease (PAD) A4 Amyloid Protein , 1988 .

[4]  P. Goldman-Rakic,et al.  Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. , 1985, Science.

[5]  E. Cudahy,et al.  Qualitative analysis of scopolamine-induced amnesia , 2004, Psychopharmacology.

[6]  Dundee Jw,et al.  The amnesic action of diazepam, flunitrazepam and lorazepam in man. , 1976 .

[7]  S. Paik,et al.  Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein , 2006, Neurobiology of Disease.

[8]  C. Albright,et al.  Therapeutic Strategies for Alzheimer’s Disease , 2008, Molecular Neurobiology.

[9]  G. R. Kelman,et al.  Differential effect of atropine and hyoscine on human learning capacity. , 1971, British journal of pharmacology.

[10]  R. Bartus,et al.  Age-related differences in behavior across the life span of the C57BL/6J mouse. , 1981, Experimental aging research.

[11]  J. Sinnott.  Aging in the 1980's: Psychological Issues , 1981 .

[12]  J. Jolles,et al.  Caffeine improves memory performance during distraction in middle‐aged, but not in young or old subjects , 1998 .

[13]  B. Therrien,et al.  Effect of antipsychotic medication use on memory in patients with Alzheimer's disease: Assessing the potential risk for accelerated recent autobiographical memory loss. , 2007, Journal of gerontological nursing.

[14]  S. Lazareno,et al.  Cholinergic treatments for Alzheimer's disease. , 1989, Biochemical Society transactions.

[15]  R. Branconnier,et al.  Cannabis: effects on memory and the cholinergic limbic system. , 1983, Psychological bulletin.

[16]  G. Lynch,et al.  Ampakines and the threefold path to cognitive enhancement , 2006, Trends in Neurosciences.

[17]  E. Roy John,et al.  Mechanisms of memory , 1967 .

[18]  R. Bartus.  The impending Alzheimer's crisis: Can we be saved by the revolution? , 1989, Neurobiology of Aging.

[19]  R. Bartus,et al.  Neuropeptide effects on memory in aged monkeys , 1982, Neurobiology of Aging.

[20]  M. Voytko.  Cognitive functions of the basal forebrain cholinergic system in monkeys: memory or attention? , 1996, Behavioural Brain Research.

[21]  Victoria Steiner,et al.  Anticholinergic medications: use among older adults with memory problems. , 2007, Journal of gerontological nursing.

[22]  W. Mcentee,et al.  Noradrenergic intervention in Alzheimer's disease. , 1992, Psychopharmacology bulletin.

[23]  M. Laakso,et al.  Clonidine impairs sustained attention and memory in Alzheimer's disease , 1999, Neuroscience.

[24]  Steven G Potkin,et al.  A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease , 2005, Nature Medicine.

[25]  R. Bartus,et al.  Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to the cerebral cortex in the rat , 1983, Pharmacology Biochemistry and Behavior.

[26]  H. Weingartner,et al.  Modest facilitation on memory in dementia with combined lecithin and anticholinerestase treatment. , 1982, Biological psychiatry.

[27]  A. Ennaceur,et al.  A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memory , 1992, Behavioural Brain Research.

[28]  R. Bartus,et al.  Lack of efficacy of clonidine on memory in aged cebus monkeys , 1988, Neurobiology of Aging.

[29]  E. Mohr,et al.  Clonidine treatment of Alzheimer's disease. , 1989, Archives of neurology.

[30]  R. Bartus.  Drugs to Treat Age‐Related Neurodegenerative Problems The Final Frontier of Medical Science? , 1990, Journal of the American Geriatrics Society.

[31]  F. Hefti,et al.  Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions , 1984, Brain Research.

[32]  G. Pepeu.  Overview and perspective on the therapy of alzheimer's disease from a preclinical viewpoint , 2001, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[33]  W. Meier-Ruge,et al.  The Actions of Hydergine® on the Brain , 1968 .

[34]  Michael F. Green,et al.  Antipsychotic and anticholinergic effects on two types of spatial memory in schizophrenia , 2004, Schizophrenia Research.

[35]  B. Harrison,et al.  Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans. , 2005, The international journal of neuropsychopharmacology.

[36]  S. Younkin,et al.  Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice , 1996, Science.

[37]  E. Mohr,et al.  Guanfacine treatment of Alzheimer's disease. , 1989, Clinical neuropharmacology.

[38]  Edward D Levin,et al.  Cognitive effects of nicotine , 2001, Biological Psychiatry.

[39]  U. Müller,et al.  Noradrenergic blockade and numeric working memory in humans , 2005, Journal of psychopharmacology.

[40]  F. Frost.  Current Research in Alzheimer Therapy , 1989 .

[41]  G. Keating,et al.  Management of Mild to Moderate Alzheimer Disease , 2004 .

[42]  Y. Christen,et al.  Genetics and Alzheimer’s Disease , 1988, Research and Perspectives in Alzheimer’s Disease.

[43]  P. Goldman-Rakic,et al.  Catecholamines and Cognitive Decline in Aged Nonhuman Primates , 1985, Annals of the New York Academy of Sciences.

[44]  H. Weingartner,et al.  Human serial learning: enhancement with arecholine and choline impairment with scopolamine. , 1978, Science.

[45]  R. Griffiths,et al.  Dose‐Response Evaluation of the Amnestic Effects of: Triazolam and Pentobarbital in Normal Subjects , 1990, Journal of clinical psychopharmacology.

[46]  M. Baxter,et al.  Spatial orienting of attention in adult and aged rhesus monkeys. , 1996, Behavioral neuroscience.

[47]  G. Lynch,et al.  Facilitative Effects of the Ampakine CX516 on Short-Term Memory in Rats: Correlations with Hippocampal Neuronal Activity , 1998, The Journal of Neuroscience.

[48]  T. Bolwig,et al.  Assessment of the anticholinergic effects of antidepressants in a single-dose cross-over study of salivation and plasma levels , 2004, Psychopharmacology.

[49]  M. Pontecorvo,et al.  The Cholinergic Hypothesis: A Historical Overview, Current Perspective, and Future Directions , 1985, Annals of the New York Academy of Sciences.

[50]  R. Bartus,et al.  On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis , 2000, Experimental Neurology.

[51]  L. Squire,et al.  Methylphenidate impairs learning and memory in normal adults. , 1981, Behavioral and neural biology.

[52]  J. Holden,et al.  Age‐related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys , 1998, The Journal of comparative neurology.

[53]  G. Glenner,et al.  Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. , 1984, Biochemical and biophysical research communications.

[54]  Gayatri Devi,et al.  A RETROSPECTIVE CHART REVIEW OF THE TOLERABILITY AND EFFICACY OF INTRAVENOUS IMMUNOGLOBULIN IN THE TREATMENT OF ALZHEIMER'S DISEASE , 2008, Journal of the American Geriatrics Society.

[55]  R. Bartus,et al.  Brain cholinergic dysfunction and memory in aged rats , 1980, Neurobiology of Aging.

[56]  W. E. Askew,et al.  Effect of tetrahydrocannabinols on brain acetylcholine. , 1974, Brain research.

[57]  R. Bartus.  Four Stimulants of the Central Nervous System: Effects on Short‐Term Memory in Young versus Aged Monkeys * , 1979, Journal of the American Geriatrics Society.

[58]  R. Bartus,et al.  Animal models for age-related memory disturbances , 1987 .

[59]  M. Glanzer,et al.  The pattern of memory loss resulting from intravenously administered diazepam. , 1979, Archives of neurology.

[60]  R. Bartus.  Cholinergic drug effects on memory and cognition in animals. , 1980 .

[61]  W. Meier-Ruge,et al.  The actions of Hydergine on the brain. A histochemical, circulatory and neurophysiological study. , 1968, Pharmacology.

[62]  G. Marsh,et al.  Use of THA in treatment of Alzheimer-like dementia: pilot study in twelve patients. , 1981, Biological psychiatry.

[63]  J. Rodefer,et al.  Selective nicotinic acetylcholine receptor agonists: potential therapies for neuropsychiatric disorders with cognitive dysfunction. , 2008, Current opinion in investigational drugs.

[64]  J. Bloch,et al.  Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. , 2000, Science.

[65]  K. Davis,et al.  Clinical Studies of the Cholinergic Deficit in Alzheimer's Disease , 1985, Journal of the American Geriatrics Society.

[66]  Kathryn A. Ellis,et al.  Muscarinic and nicotinic receptor modulation of object and spatial n-back working memory in humans , 2005, Pharmacology Biochemistry and Behavior.

[67]  D. Price,et al.  Amyloid precursor protein in aged nonhuman primates. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[68]  R. Atkinson,et al.  Marihuana and retrieval from short-term memory , 2004, Psychopharmacologia.

[69]  N. Relkin,et al.  18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease , 2009, Neurobiology of Aging.

[70]  W. K. Honig,et al.  Spatial memory deficit in senescent rats. , 1980, Canadian journal of psychology.

[71]  P. Goodnick,et al.  Chemotherapy of cognitive disorders in geriatric subjects. , 1984, The Journal of clinical psychiatry.

[72]  B. Karlén,et al.  Effects of diazepam on muscarinic acetylcholine receptor binding in vivo and on oxotremorine-induced tremor and hypothermia in mice. , 1987, Pharmacology & toxicology.

[73]  B. Sahakian,et al.  Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB , 2005, Psychopharmacology.

[74]  H. Möller,et al.  Intravenous immunoglobulins containing antibodies against β-amyloid for the treatment of Alzheimer’s disease , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[75]  K. Davis,et al.  Enhancement of memory by physostigmine. , 1979, The New England journal of medicine.

[76]  Gottfries Cg.  Alzheimer's disease. A critical review. , 1988 .

[77]  D. Medin,et al.  Age differences in retention of concurrent discrimination problems in monkeys. , 1973, Journal of gerontology.

[78]  Roger T. Davis.  Old monkey behavior , 1978, Experimental Gerontology.

[79]  M. Lader,et al.  Antidepressants and human memory: an investigation of four drugs with different sedative and anticholinergic profiles , 2004, Psychopharmacology.

[80]  J. Delacour,et al.  A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data , 1988, Behavioural Brain Research.

[81]  R. Bartus,et al.  The cholinergic hypothesis of geriatric memory dysfunction. , 1982, Science.

[82]  P. Goldman-Rakic,et al.  Enhancement of Working Memory in Aged Monkeys by a Sensitizing Regimen of Dopamine D1 Receptor Stimulation , 2004, The Journal of Neuroscience.

[83]  Howard Eichenbaum,et al.  Cognitive Aging: A Common Decline of Episodic Recollection and Spatial Memory in Rats , 2008, The Journal of Neuroscience.

[84]  B. Alescio-Lautier,et al.  Behavioral effects of basal forebrain cholinergic lesions in young adult and aging rats. , 2005, Behavioral neuroscience.

[85]  Hiroaki Kazui,et al.  Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease? , 2005, The American journal of psychiatry.

[86]  M. Weinstock.  Possible role of the cholinergic system and disease models. , 1997, Journal of neural transmission. Supplementum.

[87]  Andrew C. Leon,et al.  A Placebo-Controlled Pilot Study of the Ampakine CX516 Added to Clozapine in Schizophrenia , 2001, Journal of clinical psychopharmacology.

[88]  G. Lynch,et al.  Facilitative Effects of the Ampakine CX516 on Short-Term Memory in Rats: Enhancement of Delayed-Nonmatch-to-Sample Performance , 1998, The Journal of Neuroscience.

[89]  R. Bartus.  Evidence for a direct cholinergic involvement in the scopolamine-induced amnesia in monkeys: Effects of concurrent administration of physostigmine and methylphenidate with scopolamine , 1978, Pharmacology Biochemistry and Behavior.

[90]  B. Reisberg,et al.  Long-term choline treatment of memory-impaired elderly patients. , 1979, Science.

[91]  R. Bartus,et al.  An evaluation of drugs for improving memory in aged monkeys: implications for clinical trials in humans. , 1983, Psychopharmacology bulletin.

[92]  R. Bartus,et al.  Behavioral Models of Aging in Nonhuman Primates , 1988 .

[93]  M. Fioravanti,et al.  Effect of cholinergic and anticholinergic drugs on short-term memory in Alzheimer's dementia: a neuropsychological and computerized electroencephalographic study. , 1983, Clinical neuropharmacology.

[94]  T. Crook.  Treatment development strategies for Alzheimer's disease , 1986 .

[95]  Gary W. Small,et al.  Efficacy of Rivastigmine in Alzheimer’s Disease Patients with Rapid Disease Progression: Results of a Meta-Analysis , 2005, Dementia and Geriatric Cognitive Disorders.

[96]  R. Bartus,et al.  Memory Deficits in Aged Cebus Monkeys and Facilitation With Central Cholinomimetics , 1980, Neurobiology of Aging.

[97]  J. Haxby,et al.  Memory improvement without toxicity during chronic, low dose intravenous arecoline in Alzheimer's disease , 2005, Psychopharmacology.

[98]  Michael F. Green,et al.  A Placebo-Controlled Add-On Trial of the Ampakine, CX516, for Cognitive Deficits in Schizophrenia , 2008, Neuropsychopharmacology.

[99]  R. Bartus,et al.  Age-related changes in passive avoidance retention: modulation with dietary choline. , 1980, Science.

[100]  M. Tuszynski,et al.  Memory Impairment in Aged Primates Is Associated with Focal Death of Cortical Neurons and Atrophy of Subcortical Neurons , 2004, The Journal of Neuroscience.

[101]  S. Ferris,et al.  A visual recognition memory test for the assessment of cognitive function in aging and dementia. , 1987, Experimental aging research.

[102]  S. Bachurin,et al.  in Culture and Block L-type Ca2+ Channels , 2001 .

[103]  R. Bartus.  Physostigmine and recent memory: effects in young and aged nonhuman primates. , 1979, Science.

[104]  Trevor W Robbins,et al.  Cholinergic modulation of visual attention and working memory: dissociable effects of basal forebrain 192-IgG-saporin lesions and intraprefrontal infusions of scopolamine. , 2004, Learning & memory.

[105]  S. Gershon.  Comparative side effect profiles of trazodone and imipramine: special reference to the geriatric population. , 1984, Psychopathology.

[106]  H. Knegtering,et al.  Effects of Antidepressants on Cognitive Functioning of Elderly Patients , 1994, Drugs & aging.

[107]  R. Bartus,et al.  Short-term memory in the rhesus monkey: Disruption from the anti-cholinergic scopolamine , 1976, Pharmacology Biochemistry and Behavior.

[108]  C. Gottfries.  Alzheimer's disease. A critical review. , 1988, Comprehensive gerontology. Section C, Interdisciplinary topics.

[109]  D. Drachman,et al.  Memory and cognitive function in man , 1977, Neurology.

[110]  EDWARD F. DOMINO.  Cannabinoids And The Cholinergic System , 1981, Journal of clinical pharmacology.

[111]  ML Voytko,et al.  Basal forebrain lesions in monkeys disrupt attention but not learning and memory [published erratum appears in J Neurosci 1995 Mar;15(3): following table of contents] , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[112]  A. Wetherell.  Some effects of atropine on short-term memory. , 1980, British journal of clinical pharmacology.

[113]  J. Ferguson,et al.  Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia , 1981, British Journal of Psychiatry.

[114]  J. D. McGaugh.  Memory--a century of consolidation. , 2000, Science.

[115]  S. Ferris,et al.  Age‐associated memory impairment: Proposed diagnostic criteria and measures of clinical change — report of a national institute of mental health work group , 1986 .

[116]  S. DeKosky,et al.  Monoamine neurons in aging and Alzheimer's disease , 2005, Journal of Neural Transmission / General Section JNT.

[117]  Seth Love,et al.  Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial , 2008, The Lancet.

[118]  K. A. George,et al.  The amnesic action of diazepam, flunitrazepam and lorazepam in man. , 1978, Acta anaesthesiologica Belgica.

[119]  P. Goldman-Rakic,et al.  D1 dopamine receptors in prefrontal cortex: involvement in working memory , 1991, Science.

[120]  G. R. Kelman,et al.  Effect of methohexitone, diazepam and sodium 4-hydroxybutyrate on short-term memory. , 1971, British journal of anaesthesia.

[121]  R F Thompson.  Behaviorism and neuroscience. , 1994, Psychological review.

[122]  P. E. Gold,et al.  Changes in Learning and Memory During Aging , 1975 .

[123]  S. Zornetzer,et al.  Age-related memory deficits in Swiss mice. , 1981, Behavioral and neural biology.

[124]  M. Farlow.  Do cholinesterase inhibitors slow progression of Alzheimer's disease? , 2002, International journal of clinical practice. Supplement.

[125]  Mary Sano,et al.  Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study , 2008, The Lancet.

[126]  R. Bartus.  Short-term memory in the rhesus monkey: Effects of dopamine blockade via acute haloperidol administration , 1978, Pharmacology Biochemistry and Behavior.

[127]  N. Butters,et al.  Patterns of memory failure after scopolamine treatment: implications for cholinergic hypotheses of dementia. , 1986, Behavioral and neural biology.

[128]  E. Tangalos,et al.  Mild Cognitive Impairment Clinical Characterization and Outcome , 1999 .

[129]  D. Mungas,et al.  Effects of haloperidol on recall and information processing in verbal and spatial learning , 1990, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[130]  B. Winblad,et al.  Intracerebroventricular Infusion of Nerve Growth Factor in Three Patients with Alzheimer’s Disease , 1998, Dementia and Geriatric Cognitive Disorders.

[131]  A. Sulkowski.  Marihuana "High": A Model of Senile Dementia? , 2015, Perspectives in biology and medicine.

[132]  W. J. Jackson,et al.  Effects of concomitant cholinergic and adrenergic stimulation on learning and memory performance by primates. , 1992, Life sciences.

[133]  G. Lynch.  Memory and the Brain: Unexpected Chemistries and a New Pharmacology , 1998, Neurobiology of Learning and Memory.

[134]  K. Davis,et al.  A pilot study of clonidine plus physostigmine in Alzheimer's disease. , 1994, Dementia.

[135]  K. Davis,et al.  Clinical Studies of the Cholinergic Deficit in Alzheimer's Disease , 1985, Journal of the American Geriatrics Society.

[136]  Psychotropic effects of repeated doses of enalapril, propranolol and atenolol in normal subjects. , 1988, British journal of clinical pharmacology.

[137]  D. Price,et al.  Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits. , 1990, The American journal of pathology.

[138]  Normal Aging, Alzheimer's Disease, and Senile Dementia: Aspects on Etiology, Pathogenesis, Diagnosis and Treatment , 1986 .

[139]  J A Deutsch,et al.  The Cholinergic Synapse and the Site of Memory , 1971, Science.

[140]  V. Hirth,et al.  The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[141]  M. Pontecorvo,et al.  Selective memory loss following nucleus basalis lesions: Long term behavioral recovery despite persistent cholinergic deficiencies , 1985, Pharmacology Biochemistry and Behavior.

[142]  R. Bartus,et al.  Aging in the rhesus monkey: effects on visual discrimination learning and reversal learning. , 1979, Journal of gerontology.

[143]  B. McNaughton,et al.  Loss of place specificity in hippocampal complex spike cells of senescent rat , 1983, Neurobiology of Aging.

[144]  F. Luscombe,et al.  Safety of Tacrine: Clinical Trials, Treatment IND, and Postmarketing Experience , 1998, Alzheimer disease and associated disorders.

[145]  Edward D. Levin,et al.  Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment , 2004, Psychopharmacology.

[146]  R. Sutherland,et al.  Cognitive Deficits in Rats after Forebrain Cholinergic Depletion are Reversed by a Novel NO Mimetic Nitrate Ester , 2007, Neuropsychopharmacology.

[147]  P. Goldman-Rakic,et al.  Noradrenergic mechanisms in age-related cognitive decline. , 1987, Journal of neural transmission. Supplementum.

[148]  A. Coenen,et al.  Effects of the tranquillizer diazepam and the stimulant methylphenidate on alertness and memory. , 1997, Neuropsychobiology.

[149]  D. Drachman,et al.  Human memory and the cholinergic system. A relationship to aging? , 1974, Archives of neurology.

[150]  M. Tuszynski,et al.  Targeted Intraparenchymal Delivery of Human NGF by Gene Transfer to the Primate Basal Forebrain for 3 Months Does Not Accelerate β-Amyloid Plaque Deposition , 1998, Experimental Neurology.

[151]  R. Bartus,et al.  Tetrahydroaminoacridine, 3,4 diaminopyridine and physostigmine: Direct comparison of effects on memory in aged primates , 1988, Neurobiology of Aging.

[152]  R F Woolson,et al.  A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group. , 1992, The New England journal of medicine.

[153]  S. Ferris,et al.  The effects of aging and dementia on concept formation as measured on an object‐sorting task , 1986 .

[154]  Steven H. Ferris,et al.  Effects of aging and dementia upon recent visuospatial memory , 1984, Neurobiology of Aging.

[155]  K. Meador,et al.  Cholinergic and serotonergic effects on the P3 potential and recent memory. , 1989, Journal of clinical and experimental neuropsychology.

[156]  B. Pouzet,et al.  Beneficial effects of galantamine on performance in the object recognition task in Swiss mice: Deficits induced by scopolamine and by prolonging the retention interval , 2006, Pharmacology Biochemistry and Behavior.

[157]  M. Malaguarnera,et al.  Tacrine Treatment of Alzheimer’s Disease: Many Expectations,Few Certainties , 1998, Neuropsychobiology.

[158]  A. Kling,et al.  Oral tetrahydroaminoacridine in long-term treatment of senile dementia, Alzheimer type. , 1986, The New England journal of medicine.

[159]  H Jick,et al.  Statins and the risk of dementia , 2000, The Lancet.

[160]  H R Johnson,et al.  Aging in the rhesus monkey: debilitating effects on short-term memory. , 1978, Journal of gerontology.

[161]  F. Gage,et al.  Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. , 1996, Gene therapy.

[162]  Richard Granger,et al.  Evidence That a Positive Modulator of AMPA-Type Glutamate Receptors Improves Delayed Recall in Aged Humans , 1997, Experimental Neurology.

[163]  P. Goldman-Rakic,et al.  Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys , 1994, Psychopharmacology.

[164]  M. Tuszynski,et al.  Striatal delivery of CERE‐120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys , 2007, Movement disorders : official journal of the Movement Disorder Society.

[165]  C. Fabrigoule,et al.  Drugs with anticholinergic properties and cognitive performance in the elderly: results from the PAQUID Study. , 2005, British journal of clinical pharmacology.

[166]  S. Bachurin,et al.  Antihistamine Agent Dimebon As a Novel Neuroprotector and a Cognition Enhancer , 2001, Annals of the New York Academy of Sciences.

[167]  P. Goldman-Rakic,et al.  The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[168]  B. Reisberg,et al.  Mild cognitive impairment in the elderly , 1991, Neurology.

[169]  P. Goldman-Rakic,et al.  Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[170]  K. Davis,et al.  Induction of depression with oxotremorine in patients with Alzheimer's disease. , 1987, The American journal of psychiatry.

[171]  Agarwal Dp,et al.  Pain sensitivity in schizophrenics. , 1979 .

[172]  R. Elliott,et al.  Effects of methylphenidate on spatial working memory and planning in healthy young adults , 1997, Psychopharmacology.

[173]  T. Crook,et al.  Age-associated memory impairment: diagnostic criteria and treatment strategies. , 1987, International journal of neurology.

[174]  L. Squire.  Memory systems of the brain: A brief history and current perspective , 2004, Neurobiology of Learning and Memory.