Reproductive Biology and Endocrinology Ets-2 and P53 Mediate Camp-induced Mmp-2 Expression, Activity and Trophoblast Invasion

Background: We have previously shown that Matrix metalloproteinase (MMP)-2 is a key-enzyme in early trophoblast invasion and that Protein Kinase A (PKA) increases MMP-2 expression and trophoblast invasion. The aim of this study was to examine MMP-2 regulation by PKA in invasive trophoblasts: JAR choriocarcinoma cell-line and 6-8 w first trimester trophoblasts.

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