Public health and medicolegal implications of sleep apnoea

⇓The sleep apnoea syndrome represents something of a paradox in clinical medicine. On the one hand, this disorder has been recognised only in recent decades, and is still regarded as a niche interest by many clinicians, particularly those from clinical disciplines other than respiratory medicine, neurology and otolaryngology. On the other hand, the syndrome is now recognised as being very common and current epidemiological data indicate that sleep apnoea syndrome is second only to asthma in the prevalence league table of chronic respiratory disorders 1. Furthermore, there is increasing evidence that sleep apnoea syndrome is associated with a considerable number of adverse sequelae, both behavioural and physical. Behavioural consequences include daytime sleepiness, impaired concentration and neuropsychological dysfunction, whereas physical consequences include cardiovascular disorders, particularly hypertension. In 1997, the European Respiratory Society (ERS) established a Task Force to examine the Public Health and Medicolegal Implications of the Sleep Apnoea Syndrome with particular reference to the impact of sleepiness on patient and public safety. The following report represents the outcome of several meetings and discussions of the Task Force membership and also includes a review of current European Regulations concerning driver licensing prepared by one of the members (J. Krieger). Obstructive sleep apnoea syndrome (OSAS) is a condition characterised by repetitive obstruction of the upper airway, often resulting in oxygen desaturation and arousals from sleep. The principal daytime manifestation is excessive sleepiness but other symptoms such as unrefreshing sleep, poor concentration and fatigue are commonly reported. Early definitions of the syndrome were based on an apnoea frequency without reference to symptoms 2. However, as epidemiological data from many studies made it clear that apnoeas during sleep are very common in the general population, the definition of a clinical syndrome was revised to include certain symptoms, particularly daytime sleepiness. Hypopnoeas …

[1]  R. Chervin Epworth sleepiness scale? , 2003, Sleep medicine.

[2]  J. Manfreda,et al.  Cardiovascular medication use in patients with undiagnosed obstructive sleep apnoea , 2002, Thorax.

[3]  T. Young,et al.  Epidemiology of obstructive sleep apnea: a population health perspective. , 2002, American journal of respiratory and critical care medicine.

[4]  Crispin Jenkinson,et al.  Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial , 2002, The Lancet.

[5]  W. McNicholas,et al.  Breathing Disorders in Sleep , 2002 .

[6]  T. Gislason,et al.  Role of snoring and daytime sleepiness in occupational accidents. , 2001, American journal of respiratory and critical care medicine.

[7]  C. George Reduction in motor vehicle collisions following treatment of sleep apnoea with nasal CPAP , 2001, Thorax.

[8]  S. Esnaola,et al.  Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. , 2001, American journal of respiratory and critical care medicine.

[9]  N J Douglas,et al.  Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apnea-hypopnea syndrome. , 2001, American journal of respiratory and critical care medicine.

[10]  J. Harbison,et al.  Cardiac rhythm disturbances in the obstructive sleep apnea syndrome: effects of nasal continuous positive airway pressure therapy. , 2000, Chest.

[11]  W. McNicholas,et al.  Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome. , 2000, The European respiratory journal.

[12]  J. Hedner,et al.  Respiratory disturbance index: an independent predictor of mortality in coronary artery disease. , 2000, American journal of respiratory and critical care medicine.

[13]  Erry,et al.  Prospective study of the association between sleep-disordered breathing and hypertension. , 2000, The New England journal of medicine.

[14]  Peretz Lavie,et al.  Obstructive sleep apnoea syndrome as a risk factor for hypertension: population study , 2000, BMJ : British Medical Journal.

[15]  J. Montserrat,et al.  Time course of sleep-related breathing disorders in first-ever stroke or transient ischemic attack. , 2000, American journal of respiratory and critical care medicine.

[16]  A. Thilmann,et al.  Sleep-disordered breathing among patients with first-ever stroke , 2000, Journal of Neurology.

[17]  B M Psaty,et al.  The medical cost of undiagnosed sleep apnea. , 1999, Sleep.

[18]  J. Manfreda,et al.  Health care utilization in males with obstructive sleep apnea syndrome two years after diagnosis and treatment. , 1999, Sleep.

[19]  Daniel J Buysse,et al.  Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. , 1999, Sleep.

[20]  N. Collop,et al.  The upper airway resistance syndrome. , 1999, Chest.

[21]  J. Terán-Santos,et al.  The Association between Sleep Apnea and the Risk of Traffic Accidents , 1999 .

[22]  L J Findley,et al.  Driving with sleep apnea. , 1999, The New England journal of medicine.

[23]  M. Aldrich,et al.  Sleep apnea in acute cerebrovascular diseases: final report on 128 patients. , 1999, Sleep.

[24]  J Manfreda,et al.  Health care utilization in the 10 years prior to diagnosis in obstructive sleep apnea syndrome patients. , 1999, Sleep.

[25]  S. Benbadis,et al.  Prevalence of daytime sleepiness in a population of drivers , 1999, Neurology.

[26]  E. Bixler,et al.  Effects of age on sleep apnea in men: I. Prevalence and severity. , 1998, American journal of respiratory and critical care medicine.

[27]  L. Findley,et al.  Automobile accidents in patients with sleep apnea syndrome. An epidemiological and mechanistic study. , 1998, American journal of respiratory and critical care medicine.

[28]  M. J. Green The sleep of long-haul truck drivers. , 1998, The New England journal of medicine.

[29]  J C Sailly,et al.  Accidents in obstructive sleep apnea patients treated with nasal continuous positive airway pressure: a prospective study. The Working Group ANTADIR, Paris and CRESGE, Lille, France. Association Nationale de Traitement à Domicile des Insuffisants Respiratoires. , 1997, Chest.

[30]  David Watts Apnea , 1997, The Lancet.

[31]  J. Walsh,et al.  The sleep of long-haul truck drivers. , 1997, The New England journal of medicine.

[32]  T. Young,et al.  Sleep-disordered breathing and motor vehicle accidents in a population-based sample of employed adults. , 1997, Sleep.

[33]  J. Stradling,et al.  A behavioural test to assess daytime sleepiness in obstructive sleep apnoea , 1997, Journal of sleep research.

[34]  J. Peter,et al.  Sleep-related myocardial ischemia and sleep structure in patients with obstructive sleep apnea and coronary heart disease. , 1997, Chest.

[35]  C. Becker,et al.  Risk of traffic accidents in patients with sleep-disordered breathing: reduction with nasal CPAP. , 1996, The European respiratory journal.

[36]  G Maycock,et al.  Sleepiness and driving: the experience of UK car drivers , 1996, Journal of sleep research.

[37]  A Smiley,et al.  Simulated driving performance in patients with obstructive sleep apnea. , 1996, American journal of respiratory and critical care medicine.

[38]  N J Douglas,et al.  Self-reported use of CPAP and benefits of CPAP therapy: a patient survey. , 1996, Chest.

[39]  L. Olson,et al.  A community study of snoring and sleep-disordered breathing. Prevalence. , 1995, American journal of respiratory and critical care medicine.

[40]  M J Hensley,et al.  A community study of snoring and sleep-disordered breathing. Health outcomes. , 1995, American journal of respiratory and critical care medicine.

[41]  C. Cook,et al.  Sleep related vehicle accidents , 1995, BMJ.

[42]  P Lavie,et al.  Mortality in sleep apnea patients: a multivariate analysis of risk factors. , 1995, Sleep.

[43]  T. Gislason,et al.  Clinical Investigations: Sleep and BreathingSnoring, Apneic Episodes, and Nocturnal Hypoxemia Among Children 6 Months to 6 Years Old: An Epidemiologic Study of Lower Limit of Prevalence , 1995 .

[44]  C. Guilleminault,et al.  Traffic accidents in commercial long-haul truck drivers: the influence of sleep-disordered breathing and obesity. , 1994, Sleep.

[45]  C Guilleminault,et al.  A cause of excessive daytime sleepiness. The upper airway resistance syndrome. , 1993, Chest.

[46]  T. Young,et al.  The occurrence of sleep-disordered breathing among middle-aged adults. , 1993, The New England journal of medicine.

[47]  T. Gislason,et al.  Snoring, hypertension, and the sleep apnea syndrome. An epidemiologic survey of middle-aged women. , 1993, Chest.

[48]  J. Stradling,et al.  Self reported snoring and daytime sleepiness in men aged 35-65 years. , 1991, Thorax.

[49]  D. Kripke,et al.  Sleep-disordered breathing in community-dwelling elderly. , 1991, Sleep.

[50]  M. Johns,et al.  A new method for measuring daytime sleepiness: the Epworth sleepiness scale. , 1991, Sleep.

[51]  J. Stradling,et al.  Predictors and prevalence of obstructive sleep apnoea and snoring in 1001 middle aged men. , 1991, Thorax.

[52]  R. Collins,et al.  Blood pressure, stroke, and coronary heart disease Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context , 1990, The Lancet.

[53]  R. Collins,et al.  Blood pressure, stroke, and coronary heart disease Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias , 1990, The Lancet.

[54]  A. Foresi,et al.  Snoring in children: association with respiratory symptoms and passive smoking. , 1989, BMJ.

[55]  M. Aldrich Automobile accidents in patients with sleep disorders. , 1989, Sleep.

[56]  M. Partinen,et al.  Prevalence of every night snoring and obstructive sleep apnoeas among 30‐69‐year‐old men in Bologna, Italy , 1989, Acta neurologica Scandinavica.

[57]  M Partinen,et al.  Long-term outcome for obstructive sleep apnea syndrome patients. Mortality. , 1988, Chest.

[58]  L. Findley,et al.  Automobile accidents involving patients with obstructive sleep apnea. , 1988, The American review of respiratory disease.

[59]  M. Kryger,et al.  Mortality and apnea index in obstructive sleep apnea. Experience in 385 male patients. , 1988, Chest.

[60]  M. Partinen,et al.  Sleep apnea and mortality in an aged cohort. , 1988, American journal of public health.

[61]  N J Douglas,et al.  The sleep hypopnea syndrome. , 1988, The American review of respiratory disease.

[62]  J. Kaprio,et al.  Periodic breathing and hypoxia in snorers and controls: validation of snoring history and association with blood pressure and obesity , 1987, Acta neurologica Scandinavica.

[63]  C. Baranak,et al.  Relief of Upper Airway Obstruction by Adenotonsillectomy , 1986, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[64]  A J Block,et al.  Sleep apnea, hypopnea and oxygen desaturation in normal subjects. A strong male predominance. , 1979, The New England journal of medicine.

[65]  大竹 一生 Cardiovascular medication use in patients with undiagnosed obstructive sleep apnoea , 2003 .

[66]  K. Clark Association of Sleep-Disordered Breathing, Sleep Apnea, and Hypertension in a Large Community- Based Study , 2000 .

[67]  Daniel J Buysse,et al.  Sleep–Related Breathing Disorders in Adults: Recommendations for Syndrome Definition and Measurement Techniques in Clinical Research , 2000 .

[68]  Cost justification for diagnosis and treatment of obstructive sleep apnea. Position statement of the American Academy of Sleep Medicine. , 2000, Sleep.

[69]  D F Kripke,et al.  Prevalence of sleep-disordered breathing in ages 40-64 years: a population-based survey. , 1997, Sleep.

[70]  R. Goldberg,et al.  Epidemiology of obstructive sleep apnea. , 1994, Epidemiologic reviews.

[71]  S. Ancoli-Israel,et al.  Are breathing disturbances in elderly equivalent to sleep apnea syndrome? , 1994, Sleep.

[72]  A. Taube,et al.  Prevalence of sleep apnea syndrome among Swedish men--an epidemiological study. , 1988, Journal of clinical epidemiology.

[73]  C. Guilleminault,et al.  Sleep/Wake Disorders: Natural History, Epidemiology, and Long-Term Evolution. , 1984 .

[74]  W C Dement,et al.  The sleep apnea syndromes. , 1976, Annual review of medicine.