Molecular pharmacology of endothelin converting enzymes.

[1]  S. Kwee Mammalian brush border membrane proteins II , 1996 .

[2]  K. Tanzawa,et al.  Localization of rat endothelin-converting enzyme to vascular endothelial cells and some secretory cells. , 1995, The Biochemical journal.

[3]  J. Vane,et al.  Identification of endothelin 1 and big endothelin 1 in secretory vesicles isolated from bovine aortic endothelial cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[4]  M. Yanagisawa,et al.  Endothelin-converting Enzyme-2 Is a Membrane-bound, Phosphoramidon-sensitive Metalloprotease with Acidic pH Optimum (*) , 1995, The Journal of Biological Chemistry.

[5]  R. Corder,et al.  A simple method for isolating human endothelin converting enzyme free from contamination by neutral endopeptidase 24.11. , 1995, Biochemical and biophysical research communications.

[6]  J. Vane,et al.  Radioimmunoassay evidence that the pressor effect of big endothelindash1 is due to local conversion to endothelindash1 , 1995 .

[7]  Masashi Yanagisawa,et al.  A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease , 1994, Cell.

[8]  R. Hammer,et al.  Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons , 1994, Cell.

[9]  R. Hammer,et al.  Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice , 1994, Cell.

[10]  G. Schmalzing,et al.  Molecular characterization of human and bovine endothelin converting enzyme (ECE‐1) , 1994, FEBS letters.

[11]  H. Lodish,et al.  Signal transduction of a G protein-coupled receptor in caveolae: colocalization of endothelin and its receptor with caveolin. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[12]  A. Turner,et al.  Membrane peptidase activity of a human endothelial cell line (EA.hy 926). , 1994, Biochemical Society transactions.

[13]  A. Jeng,et al.  Pharmacological profile of a non-peptidic dual inhibitor of neutral endopeptidase 24.11 and endothelin-converting enzyme. , 1994, Biochemical and biophysical research communications.

[14]  T. Sawamura,et al.  cDNA cloning and expression of bovine endothelin converting enzyme. , 1994, Biochemical and biophysical research communications.

[15]  A. Mallet,et al.  Generation by the phosphoramidon‐sensitive peptidases, endopeptidase‐24.11 and thermolysin, of endothelin‐1 and C‐terminal fragment from big endothelin‐1 , 1994, British journal of pharmacology.

[16]  A. Doherty,et al.  Endothelin receptor antagonists: actions and rationale for their development. , 1994, Biochemical pharmacology.

[17]  M. Yanagisawa,et al.  ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1 , 1994, Cell.

[18]  K. Tanzawa,et al.  Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells. , 1994, The Journal of biological chemistry.

[19]  K. Rothberg,et al.  Purification and characterization of smooth muscle cell caveolae , 1994, The Journal of cell biology.

[20]  R. F. Cook,et al.  Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease , 1994, The Journal of cell biology.

[21]  J. Tang,et al.  Membrane association and oligomeric organization of the alpha and beta subunits of mouse meprin A. , 1994, The Journal of biological chemistry.

[22]  T. Hayama,et al.  Aminophosphonate endothelin converting enzyme inhibitors: potency-enhancing and selectivity-improving modifications of phosphoramidon , 1994 .

[23]  A. Turner,et al.  Processing and metabolism of peptide-YY: pivotal roles of dipeptidylpeptidase-IV, aminopeptidase-P, and endopeptidase-24.11. , 1994, Endocrinology.

[24]  Y. Ouchi,et al.  Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1 , 1994, Nature.

[25]  M. King Blood group antigens on human erythrocytes-distribution, structure and possible functions. , 1994, Biochimica et biophysica acta.

[26]  K. Ohnaka,et al.  Purification and characterization of a phosphoramidon-sensitive endothelin-converting enzyme in porcine aortic endothelium. OFF. , 1993, The Journal of biological chemistry.

[27]  B. Roques,et al.  Identification and characterization of a neutral endopeptidase activity in Aplysia californica. , 1993, The Biochemical journal.

[28]  K. Okada,et al.  Big endothelin-1 structure important for specific processing by endothelin-converting enzyme of bovine endothelial cells. , 1993, European journal of biochemistry.

[29]  W. Neidhart,et al.  Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist , 1993, Nature.

[30]  K. Tanzawa,et al.  Purification and characterization of endothelin-converting enzyme from rat lung. , 1993, The Journal of biological chemistry.

[31]  D. Kohan Endothelins in the kidney: physiology and pathophysiology. , 1993, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[32]  K. Fujita,et al.  Endothelium-independent pressor effect of big endothelin-1 and its inhibition by phosphoramidon in rat mesenteric artery. , 1993, European journal of pharmacology.

[33]  W. G. Haynes,et al.  Endothelins as regulators of growth and function in endocrine tissues , 1993, Clinical endocrinology.

[34]  E. Golomb,et al.  Metabolism of endothelin‐1 and big endothelin‐1 by recombinant neutral endopeptidase EC.3.4.24.11 , 1993, British journal of pharmacology.

[35]  A. Turner Endothelin-converting enzymes and other families of metallo-endopeptidases. , 1993, Biochemical Society transactions.

[36]  B. Roques Zinc metallopeptidases: active site structure and design of selective and mixed inhibitors: new approaches in the search for analgesics and anti-hypertensives. , 1993, Biochemical Society transactions.

[37]  E. Pedrazzini,et al.  In vivo expression of mutant preproendothelins: hierarchy of processing events but no strict requirement of Trp-Val at the processing site. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[38]  M. Fournié-Zaluski,et al.  Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology. , 1993, Pharmacological reviews.

[39]  R. G. Anderson,et al.  Potocytosis of small molecules and ions by caveolae. , 1993, Trends in cell biology.

[40]  A. Soriano,et al.  Identification of a novel aspartyl endothelin converting enzyme in porcine aortic endothelial cells. , 1993, Biochemistry and molecular biology international.

[41]  N. Rawlings,et al.  Evolutionary families of peptidases. , 1993, The Biochemical journal.

[42]  R. Isaac,et al.  Octapamine N-acetyltransferase activity from the cattle tick, Boophilus microplus , 1992 .

[43]  Weiping Jiang,et al.  Families of metalloendopeptidases and their relationships , 1992, FEBS letters.

[44]  E. Golomb,et al.  Role of neutral endopeptidase in the metabolism of endothelin. , 1992, Hypertension.

[45]  M. Dunn,et al.  The molecular mechanisms of cardiovascular and renal regulation by endothelin peptides. , 1992, The Journal of laboratory and clinical medicine.

[46]  P. S. Robinson,et al.  Kinetic parameters for the generation of endothelins-1,-2 and -3 by human cathepsin E. , 1992, The Biochemical journal.

[47]  P. Savage,et al.  Identification and partial purification of a thiol endothelin-converting enzyme from porcine aortic endothelial cells. , 1992, Journal of biochemistry.

[48]  Richard G. W. Anderson,et al.  Caveolin, a protein component of caveolae membrane coats , 1992, Cell.

[49]  J. Wiseman,et al.  Role of mast cell chymase in the extracellular processing of big-endothelin-1 to endothelin-1 in the perfused rat lung. , 1992, Biochemical pharmacology.

[50]  T. Waldron,et al.  The effects of novel cathepsin E inhibitors on the big endothelin pressor response in conscious rats. , 1992, Biochemical and biophysical research communications.

[51]  F. Fyhrquist,et al.  Endothelin-1 is expressed and released by a human endothelial hybrid cell line (EA.hy 926). , 1991, Biochemical and biophysical research communications.

[52]  K. Miki,et al.  Phosphoramidon-sensitive endothelin converting enzyme in rat lung. , 1991, Biochemistry international.

[53]  C. S. Scott,et al.  A highly sensitive E.L.I.S.A. for endopeptidase-24.11, the common acute-lymphoblastic-leukaemia antigen (CALLA, CD-10), applicable to material of porcine and human origin. , 1991, The Biochemical journal.

[54]  B. Roques,et al.  Identification of glutamic acid 646 as a zinc-coordinating residue in endopeptidase-24.11. , 1991, The Journal of biological chemistry.

[55]  R. Ikegawa,et al.  N-ethylmaleimide differentiates endothelin converting activity by two types of metalloproteinases derived from vascular endothelial cells. , 1991, Biochemical and biophysical research communications.

[56]  Soohee Lee,et al.  Molecular cloning and primary structure of Kell blood group protein. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[57]  R. Ikegawa,et al.  Phosphoramidon inhibits the conversion of intracisternally administered big endothelin-1 to endothelin-1. , 1991, Biochemical and biophysical research communications.

[58]  D. Pollock,et al.  Evidence for metalloprotease involvement in the in vivo effects of big endothelin 1. , 1991, The American journal of physiology.

[59]  P. P. Shields,et al.  Accumulation of pepstatin in cultured endothelial cells and its effect on endothelial processing. , 1991, Biochemical and biophysical research communications.

[60]  K. Okada,et al.  Phosphoramidon-sensitive endothelin-converting enzyme in the cytosol of cultured bovine endothelial cells. , 1991, Biochemical and biophysical research communications.

[61]  W. M. Moore,et al.  Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[62]  K. Okada,et al.  Endothelin converting enzyme of bovine carotid artery smooth muscles. , 1991, Biochemical and biophysical research communications.

[63]  M. Yanagisawa,et al.  Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells. , 1991, Biochemical and biophysical research communications.

[64]  J. Vane,et al.  The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. , 1991, Biochemical and biophysical research communications.

[65]  B. Roques,et al.  Evidence that both arginine 102 and arginine 747 are involved in substrate binding to neutral endopeptidase (EC 3.4.24.11). , 1991, The Journal of biological chemistry.

[66]  R. Ikegawa,et al.  Proteolytic processing of porcine big endothelin-1 catalyzed by cathepsin D. , 1990, Biochemical and biophysical research communications.

[67]  K. Chien,et al.  Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy. , 1990, The Journal of biological chemistry.

[68]  M. Yanagisawa,et al.  Analysis of big endothelin-1 digestion by cathepsin D. , 1990, Biochemical and biophysical research communications.

[69]  K. Okada,et al.  Inhibition of biological actions of big endothelin-1 by phosphoramidon. , 1990, Biochemical and biophysical research communications.

[70]  J. Kay,et al.  Generation of human endothelin by cathepsin E , 1990, FEBS letters.

[71]  R. Ikegawa,et al.  Conversion of big endothelin‐1 to endothelin‐1 by two types of metalloproteinases derived from porcine aortic endothelial cells , 1990, FEBS letters.

[72]  C. Gandhi,et al.  Endothelin, a potent peptide agonist in the liver. , 1990, The Journal of biological chemistry.

[73]  K. Okada,et al.  Conversion of big endothelin-1 by membrane-bound metalloendopeptidase in cultured bovine endothelial cells. , 1990, Biochemical and biophysical research communications.

[74]  J. R. Wu-wong,et al.  Characterization of endothelin converting enzyme in rat lung. , 1990, Biochemical and biophysical research communications.

[75]  M. Shipp,et al.  Downregulation of enkephalin-mediated inflammatory responses by CDl0/neutral endopeptidase 24.11 , 1990, Nature.

[76]  R. Ikegawa,et al.  Phosphoramidon, a metalloproteinase inhibitor, suppresses the secretion of endothelin-1 from cultured endothelial cells by inhibiting a big endothelin-1 converting enzyme. , 1990, Biochemical and biophysical research communications.

[77]  R. Ikegawa,et al.  Mode of cleavage of pig big endothelin-1 by chymotrypsin. Production and degradation of mature endothelin-1. , 1990, The Biochemical journal.

[78]  L. Hersh,et al.  The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase). , 1990, The Journal of biological chemistry.

[79]  M. Takaoka,et al.  Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1. , 1990, European journal of pharmacology.

[80]  M. Yanagisawa,et al.  Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells. , 1990, Biochemical and biophysical research communications.

[81]  Y. Kloog,et al.  Endothelins are more sensitive than sarafotoxins to neutral endopeptidase: possible physiological significance. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[82]  M. Yanagisawa,et al.  Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: evidence for a cathepsin D-like enzyme. , 1990, Biochemical and biophysical research communications.

[83]  K. Ohnaka,et al.  Identification and characterization of endothelin converting activity in cultured bovine endothelial cells. , 1990, Biochemical and biophysical research communications.

[84]  R. Ikegawa,et al.  Evidence for pepstatin-sensitive conversion of porcine big endothelin-1 to endothelin-1 by the endothelial cell extract. , 1990, Biochemical and biophysical research communications.

[85]  R. Ikegawa,et al.  Conversion of porcine big endothelin to endothelin by an extract from the porcine aortic endothelial cells. , 1990, Biochemical and biophysical research communications.

[86]  R. Ikegawa,et al.  Pepsin, an aspartic protease, converts porcine big endothelin to 21-residue endothelin. , 1990, Biochemical and biophysical research communications.

[87]  L. Hersh,et al.  Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant. , 1989, The Journal of biological chemistry.

[88]  M. Yanagisawa,et al.  The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[89]  N. Hooper,et al.  Ectoenzymes of the kidney microvillar membrane. Affinity purification, characterization and localization of the phospholipase C-solubilized form of renal dipeptidase. , 1989, The Biochemical journal.

[90]  A. Bairoch,et al.  A unique signature identifies a family of zinc‐dependent metallopeptidases , 1989, FEBS letters.

[91]  P Corvol,et al.  Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[92]  R. Isaac Neuropeptide-degrading endopeptidase activity of locust (Schistocerca gregaria) synaptic membranes. , 1988, The Biochemical journal.

[93]  R. Mcinnes,et al.  Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase , 1988, The Journal of experimental medicine.

[94]  Sadao Kimura,et al.  A novel potent vasoconstrictor peptide produced by vascular endothelial cells , 1988, Nature.

[95]  N. Hooper,et al.  Ectoenzymes of the kidney microvillar membrane Aminopeptidase P is anchored by a glycosyl‐phosphatidylinositol moiety , 1988, FEBS letters.

[96]  N. Hooper,et al.  Renal dipeptidase is one of the membrane proteins released by phosphatidylinositol-specific phospholipase C. , 1987, The Biochemical journal.

[97]  H. Lodish,et al.  The sucrase-isomaltase complex: Primary structure, membrane-orientation, and evolution of a stalked, intrinsic brush border protein , 1986, Cell.

[98]  R. Skidgel,et al.  Neutral endopeptidase 24.11 in human neutrophils: cleavage of chemotactic peptide. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[99]  A. Turner,et al.  Endopeptidase-24.11 and neuropeptide metabolism. , 1985, Biochemical Society transactions.

[100]  B. Matthews,et al.  Binding of N-carboxymethyl dipeptide inhibitors to thermolysin determined by X-ray crystallography: a novel class of transition-state analogues for zinc peptidases. , 1984, Biochemistry.

[101]  C. Edgell,et al.  Permanent cell line expressing human factor VIII-related antigen established by hybridization. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[102]  A. Kenny,et al.  Proteins of the kidney microvillar membrane. The amphipathic forms of endopeptidase purified from pig kidneys. , 1983, The Biochemical journal.

[103]  A. Turner,et al.  Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[104]  C. Bordier Phase separation of integral membrane proteins in Triton X-114 solution. , 1981, The Journal of biological chemistry.

[105]  J. Schwartz,et al.  The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice , 1980, Nature.

[106]  B. Matthews,et al.  A crystallographic study of the complex of phosphoramidon with thermolysin. A model for the presumed catalytic transition state and for the binding of extended substances. , 1977, Journal of molecular biology.

[107]  A. Barrett Proteinases in Mammalian Cells and Tissues , 1977 .

[108]  T. Aoyagi,et al.  A THERMOLYSIN INHIBITOR PRODUCED BY ACTINOMYCETES: PHOSPHORAMIDON , 1973 .

[109]  Turner Aj PIG-tailed membrane proteins. , 1994 .

[110]  P. Blache,et al.  Miniglucagon production from glucagon: an extracellular processing of a hormone used as a prohormone. , 1994, Biochimie.

[111]  A. Turner,et al.  Post-secretory processing of regulatory peptides: the pancreatic polypeptide family as a model example. , 1994, Biochimie.

[112]  A. Stern,et al.  Identification and characterization of endothelin converting activity from EAHY 926 cells: evidence for the physiologically relevant human enzyme. , 1994, Archives of biochemistry and biophysics.

[113]  A. Turner Purification of membrane-associated proteins , 1993 .

[114]  A. Knap,et al.  A comparison of endothelin-converting enzyme activity from primary porcine aortic endothelial cells with activities in cultured human cell lines. , 1993, Journal of cardiovascular pharmacology.

[115]  N. Emoto,et al.  Intracellular localization of membrane-bound endothelin-converting enzyme from rat lung. , 1993, Journal of cardiovascular pharmacology.

[116]  A. Turner,et al.  Processing and metabolism of endothelin peptides by porcine lung membranes. , 1993, Journal of cardiovascular pharmacology.

[117]  J. Vane,et al.  Effects of phosphoramidon in endothelial cell cultures on the endogenous synthesis of endothelin-1 and on conversion of exogenous big endothelin-1 to endothelin-1. , 1993, Journal of cardiovascular pharmacology.

[118]  R. Leduc,et al.  Presence of furin mRNA in cultured bovine endothelial cells and possible involvement of furin in the processing of the endothelin precursor. , 1993, Journal of cardiovascular pharmacology.

[119]  A. Turner Membrane peptidases of the nervous and immune systems , 1993 .

[120]  L. Hersh,et al.  Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[121]  A. Turner Neuropeptides and their peptidases , 1987 .

[122]  A. Kenny,et al.  Topology of microvillar membrance hydrolases of kidney and intestine. , 1982, Physiological reviews.

[123]  U. Ryan,et al.  Localization of angiotensin converting enzyme (kininase II). I. Preparation of antibody-hemeoctapeptide conjugates. , 1976, Tissue & cell.

[124]  M. Chobert,et al.  Molecular cloning and nucleotide sequence of rat kidney y-glutamyl transpeptidase cDNA , 2022 .