Design, synthesis and biological evaluations of novel pyridone-thiazole hybrid molecules as antitumor agents.

[1]  Paul W Smith,et al.  Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents. , 2015, European journal of medicinal chemistry.

[2]  Sameh Eid,et al.  Design, synthesis, antimicrobial evaluation and molecular docking studies of some new thiophene, pyrazole and pyridone derivatives bearing sulfisoxazole moiety. , 2014, European journal of medicinal chemistry.

[3]  Wenlin Xie,et al.  Design and synthesis of novel 5,6-disubstituted pyridine-2,3-dione-3-thiosemicarbazone derivatives as potential anticancer agents. , 2014, European journal of medicinal chemistry.

[4]  M. Seleem,et al.  Discovery and characterization of potent thiazoles versus methicillin- and vancomycin-resistant Staphylococcus aureus. , 2014, Journal of medicinal chemistry.

[5]  S. Bondock,et al.  Synthesis of some new 2-(3-pyridyl)-4,5-disubstituted thiazoles as potent antimicrobial agents. , 2013, European journal of medicinal chemistry.

[6]  S. Mattapally,et al.  Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiesterase3 (PDE3): a target for heart failure and platelet aggregation. , 2012, Bioorganic & medicinal chemistry letters.

[7]  H. Jung,et al.  Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors. , 2012, Bioorganic & medicinal chemistry letters.

[8]  Wenlin Xie,et al.  A Facile and Efficient Iodination of 5,6-Di(Arylamino)Pyridine-2,3-Diones , 2012 .

[9]  S. Giri,et al.  Effects of Two Anti-TNF-α Compounds: Etanercept and 5-Ethyl-1-phenyl-2-(1H)-pyridone on Secreted and Cell-Associated TNF-α in Vitro , 2011 .

[10]  Jilu Feng,et al.  Design, synthesis, and antihepatitis B virus activities of novel 2-pyridone derivatives. , 2010, Journal of medicinal chemistry.

[11]  P. Carrupt,et al.  Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship. , 2008, Journal of medicinal chemistry.

[12]  S. Gil,et al.  New Synthetic Methods to 2-Pyridone Rings , 2005 .

[13]  N. Nakanishi,et al.  Structure of TMC-69, a new antitumor antibiotic from Chrysosporium sp. TC 1068 , 2001 .

[14]  V. Onnis,et al.  Synthesis and antitumour activity of 4-hydroxy-2-pyridone derivatives. , 2000, European journal of medicinal chemistry.

[15]  R. Hertzberg,et al.  Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. , 1985, The Journal of biological chemistry.