Effect of acute desmopressin and of long‐term thyroxine replacement on haemostasis in hypothyroidism

OBJECTIVE Hypothyroidism can be complicated by bleeding symptoms such as easy bruising, menorrhagla and sometimes even a severe bleeding tendency with fatal outcome. Usually there is a prolonged bleeding time, or a low plasma concentration of coagulation factor VIII (FVIII) or von Willebrand factor (vWF). The aim of the present study was to investigate the acute haemostatic effect of desmopressin in hypothyroid patients. Another aim was to study the long‐term effect of thyroxine replacement on the plasma concentrations of coagulation factors and to ascertain the duration of thyroxine treatment needed to restore haemostatic function.

[1]  A. Babson,et al.  Comparative evaluation of a partial thromboplastin reagent containing a non-settling, particulate activator. , 1974, American journal of clinical pathology.

[2]  A. Hellem.  Platelet adhesiveness in von Willebrand's disease. A study with a new modification of the glass bead filter method. , 2009, Scandinavian journal of haematology.

[3]  W. O'Fallon,et al.  Outcome of anesthesia and surgery in hypothyroid patients. , 1983, Archives of internal medicine.

[4]  P. Mannucci,et al.  Immunoradiometric Assay of Factor VIII Related Antigen, with Observations in 32 Patients with von Willebrand's Disease , 1976, British journal of haematology.

[5]  M. Greaves,et al.  HYPOTHYROIDISM AS A CAUSE OF ACQUIRED VON WDLLEBRAND'S DISEASE , 1987, The Lancet.

[6]  N. Farid,et al.  Blood Coagulation and Fibrinolysis in Thyroid Disease , 1976, Thrombosis and Haemostasis.

[7]  F. Orr.  Haemorrhage in myxoedema coma. , 1962, The Lancet.

[8]  P. Maccallum,et al.  HYPOTHYROIDISM AND VON WILLEBRAND'S DISEASE , 1987, The Lancet.

[9]  Shane,et al.  Factor VIII activity in normal volunteers receiving oral thyroid hormone. , 1983, The Journal of laboratory and clinical medicine.

[10]  S. Lethagen,et al.  Intranasal and Intravenous Administration of Desmopressin: Effect on F VIII/vWF, Pharmacokinetics and Reproducibility , 1987, Thrombosis and Haemostasis.

[11]  S. Lethagen.  Desmopressin (DDAVP), tranexamic acid and haemostasis , 1993 .

[12]  A. Vagnucci,et al.  Hemostatic defects in response to aspirin challenge in hypothyroidism , 1986, American journal of hematology.

[13]  Z. Ruggeri,et al.  The complex multimeric composition of factor VIII/von Willebrand factor. , 1981, Blood.

[14]  S. Lethagen,et al.  DDAVP‐induced enhancement of platelet retention: Its dependence on platelet‐von Willebrand Factor and the platelet receptor GP IIb/IIIa , 1992, European journal of haematology.

[15]  R. Doe,et al.  Low platelet adhesiveness and other hemostatic abnormalities in hypothyroidism. , 1975, Annals of internal medicine.

[16]  P. Vuopio.  Red cell enzymes in anemia. , 1963, Scandinavian journal of clinical and laboratory investigation.

[17]  H. Ford,et al.  Haemostasis in hypothyroidism. , 1990, Postgraduate medical journal.

[18]  P. Mannucci.  Desmopressin: a nontransfusional form of treatment for congenital and acquired bleeding disorders. , 1988, Blood.

[19]  F. Orr.  HÆMORRHAGE IN MYXŒDEMA COMA , 1962 .

[20]  G. Guthrie,et al.  Hypothyroidism: diversity of presentation. , 1984, Endocrine reviews.

[21]  S. Lethagen,et al.  New Bleeding Time Devices with Retractable Blades Evaluated in Children, Healthy Volunteers and Patients with Prolonged Bleeding Time , 1993, Thrombosis and Haemostasis.

[22]  S. Lethagen,et al.  Clinical application of the chromogenic assay of factor VIII in haemophilia A, and different variants of von Willebrand's disease. , 2009, Scandinavian journal of haematology.

[23]  I. Nilsson,et al.  The use of monoclonal antibodies in measuring factor VIII/von Willebrand factor. , 1985, Scandinavian journal of clinical and laboratory investigation.

[24]  C. Abildgaard,et al.  Blood coagulation in thyroid dysfunction. , 1965, The New England journal of medicine.

[25]  P. Ladenson,et al.  Complications of surgery in hypothyroid patients. , 1984, The American journal of medicine.

[26]  A. Vagnucci,et al.  Exaggeration of defective platelet function by methyldopa in hypothyroidism , 1984, American journal of hematology.

[27]  P. Owren,et al.  The control of dicumarol therapy and the quantitative determination of prothrombin and proconvertin. , 1951, Scandinavian journal of clinical and laboratory investigation.

[28]  A. Hellem,et al.  The adhesiveness of human blood platelets and thyroid function. , 2009, Acta medica Scandinavica.