NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis
暂无分享,去创建一个
M. Fishbein | D. Zemmour | Shuang Chen | C. Santiskulvong | M. Noval Rivas | T. Crother | M. Arditi | K. Shimada | T. T. Carvalho | Rebecca A. Porritt | M. Narayanan | Youngho Lee | M. Abe | Angela C. Gomez | D. Martinon | Thacyana T. Carvalho | Meena Narayanan | Magali Noval Rivas
[1] B. Cherqaoui,et al. Phase II Open Label Study of Anakinra in Intravenous Immunoglobulin–Resistant Kawasaki Disease , 2020, Arthritis & rheumatology.
[2] M. Noval Rivas,et al. Kawasaki disease: pathophysiology and insights from mouse models , 2020, Nature Reviews Rheumatology.
[3] J. Coselli,et al. Targeting the NLRP3 Inflammasome With Inhibitor MCC950 Prevents Aortic Aneurysms and Dissections in Mice , 2020, Journal of the American Heart Association.
[4] Y. Takeishi,et al. Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease. , 2019, Journal of molecular and cellular cardiology.
[5] J. Konvalinka,et al. MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition , 2019, PLoS biology.
[6] M. Fishbein,et al. Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation. , 2019, Immunity.
[7] Lei Xu,et al. The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction. , 2019, International immunopharmacology.
[8] J. Ting,et al. The NLRP3 inflammasome: molecular activation and regulation to therapeutics , 2019, Nature Reviews Immunology.
[9] Clint L. Miller,et al. Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis , 2019, Nature Medicine.
[10] Paul J. Hoffman,et al. Comprehensive Integration of Single-Cell Data , 2018, Cell.
[11] E. Natour,et al. Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation. , 2019, Arteriosclerosis, thrombosis, and vascular biology.
[12] C. Day,et al. MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition , 2019, Nature Chemical Biology.
[13] Virginia Savova,et al. Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species. , 2019, Immunity.
[14] Horacio Pérez-Sánchez,et al. MCC950 closes the active conformation of NLRP3 to an inactive state , 2019, Nature Chemical Biology.
[15] Xiaoqiong Gu,et al. The IL-1B Gene Polymorphisms rs16944 and rs1143627 Contribute to an Increased Risk of Coronary Artery Lesions in Southern Chinese Children with Kawasaki Disease , 2019, Journal of immunology research.
[16] Allon M Klein,et al. Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data. , 2019, Cell systems.
[17] M. Fishbein,et al. Myocardial fibrosis after adrenergic stimulation as a long-term sequela in a mouse model of Kawasaki disease vasculitis. , 2019, JCI insight.
[18] Lai Guan Ng,et al. Dimensionality reduction for visualizing single-cell data using UMAP , 2018, Nature Biotechnology.
[19] Atul J. Butte,et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage , 2018, Nature Immunology.
[20] J. Kanegaye,et al. Kawasaki Disease Outcomes and Response to Therapy in a Multiethnic Community: A 10‐Year Experience , 2018, The Journal of pediatrics.
[21] C. Hoggart,et al. Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature , 2018, JAMA pediatrics.
[22] J. Stéphan,et al. Severe Late-Onset Kawasaki Disease Successfully Treated With Anakinra. , 2018, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.
[23] K. Schroder,et al. MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice , 2018, Scientific Reports.
[24] V. Pascual,et al. Whole blood transcriptional profiles as a prognostic tool in complete and incomplete Kawasaki Disease , 2018, PloS one.
[25] Charlotte Soneson,et al. Bias, robustness and scalability in single-cell differential expression analysis , 2018, Nature Methods.
[26] H. Reumaux,et al. Usefulness and safety of anakinra in refractory Kawasaki disease complicated by coronary artery aneurysm , 2018, Cardiology in the Young.
[27] G. Kaplanski. Interleukin‐18: Biological properties and role in disease pathogenesis , 2017, Immunological reviews.
[28] Kei Takahashi,et al. Histopathological aspects of cardiovascular lesions in Kawasaki disease , 2017, International journal of rheumatic diseases.
[29] Qingsong Liu,et al. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders , 2017, The Journal of experimental medicine.
[30] C. Garlanda,et al. IL-1R8 is a checkpoint in NK cells regulating anti-tumor and anti-viral activity , 2017, Nature.
[31] P. Libby,et al. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease , 2017, The New England journal of medicine.
[32] J. Kuiper,et al. NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice—Brief Report , 2017, Arteriosclerosis, thrombosis, and vascular biology.
[33] B. McCrindle,et al. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association , 2017, Circulation.
[34] M. Fishbein,et al. CD8+ T Cells Contribute to the Development of Coronary Arteritis in the Lactobacillus casei Cell Wall Extract–Induced Murine Model of Kawasaki Disease , 2017, Arthritis & rheumatology.
[35] J. Burns,et al. Review: Found in Translation: International Initiatives Pursuing Interleukin‐1 Blockade for Treatment of Acute Kawasaki Disease , 2017, Arthritis & rheumatology.
[36] B. McCrindle,et al. Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease , 2016, The Journal of Immunology.
[37] Patrik L. Ståhl,et al. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics , 2016, Science.
[38] J. Newburger,et al. Rationale and study design for a phase I/IIa trial of anakinra in children with Kawasaki disease and early coronary artery abnormalities (the ANAKID trial). , 2016, Contemporary clinical trials.
[39] M. Fishbein,et al. Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease–Associated Abdominal Aortic Aneurysm , 2016, Arteriosclerosis, thrombosis, and vascular biology.
[40] V. Nizet,et al. IL-1β is an innate immune sensor of microbial proteolysis. , 2016, Science immunology.
[41] M. Fishbein,et al. IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1&agr; and IL-1&bgr; , 2015, Arteriosclerosis, thrombosis, and vascular biology.
[42] J. Burns,et al. The immunomodulatory effects of intravenous immunoglobulin therapy in Kawasaki disease , 2015, Expert review of clinical immunology.
[43] Ash A. Alizadeh,et al. Robust enumeration of cell subsets from tissue expression profiles , 2015, Nature Methods.
[44] K. Schroder,et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases , 2015, Nature Medicine.
[45] B. Moffett,et al. Epidemiology of Immunoglobulin Resistant Kawasaki Disease: Results from a Large, National Database , 2015, Pediatric Cardiology.
[46] C. Khor,et al. Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease , 2014, Genome Medicine.
[47] Wei-Chiao Chang,et al. Single-Nucleotide Polymorphism rs7251246 in ITPKC Is Associated with Susceptibility and Coronary Artery Lesions in Kawasaki Disease , 2014, PloS one.
[48] J. Orenstein,et al. Three Linked Vasculopathic Processes Characterize Kawasaki Disease: A Light and Transmission Electron Microscopic Study , 2012, PloS one.
[49] G. Owens,et al. Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms. , 2012, Physiological genomics.
[50] M. Fishbein,et al. Interleukin-1&bgr; Is Crucial for the Induction of Coronary Artery Inflammation in a Mouse Model of Kawasaki Disease , 2012, Circulation.
[51] G. Owens,et al. Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice. , 2012, The Journal of clinical investigation.
[52] Calvin Lin,et al. Transcript abundance patterns in Kawasaki disease patients with intravenous immunoglobulin resistance. , 2010, Human immunology.
[53] C. Gabay,et al. IL-1 pathways in inflammation and human diseases , 2010, Nature Reviews Rheumatology.
[54] Kai-Sheng Hsieh,et al. IL-1B polymorphism in association with initial intravenous immunoglobulin treatment failure in Taiwanese children with Kawasaki disease. , 2010, Circulation journal : official journal of the Japanese Circulation Society.
[55] Yusuke Nakamura,et al. ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms , 2008, Nature Genetics.
[56] A. Daugherty,et al. Interleukin-18 Enhances Atherosclerosis in Apolipoprotein E−/− Mice Through Release of Interferon-&ggr; , 2002, Circulation research.
[57] S. Crawford,et al. CTLA-4 (CD152) Expression in T Cells during the Acute Stage of Kawasaki Disease , 2003, Pediatric Research.
[58] H. Jäck,et al. IgA plasma cells in vascular tissue of patients with Kawasaki syndrome. , 1997, Journal of Immunology.
[59] J. Newburger,et al. ENDOTHELIAL CELL ACTIVATION AND HIGH INTERLEUKIN-1 SECRETION IN THE PATHOGENESIS OF ACUTE KAWASAKI DISEASE , 1989, The Lancet.
[60] P. Pelkonen,et al. Circulating interleukin-1 beta in patients with Kawasaki disease. , 1988, The New England journal of medicine.
[61] H. Kato,et al. Peripheral blood monocyte/macrophages and serum tumor necrosis factor in Kawasaki disease. , 1988, Clinical immunology and immunopathology.