Miniature end‐plate currents and potentials generated by quanta of acetylcholine in glycerol‐treated toad sartorius fibres

1. Part of the end‐plate region of glycerol‐treated toad sartorius muscle fibres in a hypertonic solution was voltage‐clamped using two microelectrodes. The control was adequate for recording miniature end‐plate currents (m.e.p.c.s) in the vicinity of the electrodes only, at clamp potentials from — 20 to — 100 mV. At any potential, the peak amplitude of m.e.p.c.s varied widely but their mean amplitude was linearly related to clamp potential. The equilibrium potential, obtained by extrapolation, was more positive than in normal fibres.

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