Dose dependency of radiation-induced creatine excretion in rat urine.

Creatine excretion in urine of rats after whole-body exposure to various doses of x rays (25 to 1000 r) and after sham-irradiation was determined. Although creatinuria was observed at all levels of exposure, the degree was dependent on the dose. Creatinuria lasted from 3 to 16 days after exposure. In the intermediate dose range a second rise in the excretion of creatine was observed during the second week after exposure. The average creatine excretion during the initial 4 days after exposure varied linearly with the dose up to 650 r.

[1]  L. Hempelmann,et al.  Urinary excretion of several metabolites in persons accidentally exposed to ionizing radiation. , 1961, Radiation research.

[2]  G. Gerber,et al.  Method for Isolation and Determination of Creatine and Glycocyamine , 1961 .

[3]  L. Hempelmann,et al.  Creatine metabolism after x-irradiation of rats. , 1961, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[4]  R. Dowben,et al.  Postirradiation creatinuria in the rat. , 1957, Radiation research.

[5]  L. Hempelmann,et al.  Creatine–Creatinine Metabolism in Radiation Myopathy , 1955, Nature.

[6]  D. V. Slyke,et al.  Quantitative clinical chemistry , 1931 .

[7]  O. Folin,et al.  A system of blood analysis , 1919 .