High Prevalence of the CD14-159CC Genotype in Patients Infected with Severe Acute Respiratory Syndrome-Associated Coronavirus

ABSTRACT To investigate whether genetic factors of innate immunity might influence susceptibility and/or progression in individuals infected with SARS, we evaluated the CD14 gene polymorphism in 198 Hong Kong blood donors and 152 Hong Kong severe acute respiratory syndrome (SARS) patients who were previously genotyped for FcγRIIA polymorphisms. The prevalence of the CD14-159CC polymorphism was significantly higher in the patients with severe SARS than in the those with mild SARS or controls (31% versus 15% [mild SARS] or 20% [controls]; mild SARS: P = 0.029; odds ratio, 2.74; 95% confidence interval, 1.15 to 6.57; controls, P = 0.04; odds ratio, 2.41; 95% confidence interval, 1.05 to 5.54), and both CD14-159CC and FcγRIIA-RR131 are risk genotypes for severe SARS-CoV infection.

[1]  J. Sung,et al.  Influence of FcγRIIA and MBL polymorphisms on severe acute respiratory syndrome , 2005, Tissue antigens.

[2]  G. Wong,et al.  CD14 and toll-like receptors: potential contribution of genetic factors and mechanisms to inflammation and allergy. , 2005, Current drug targets. Inflammation and allergy.

[3]  S. Weiland,et al.  A promoter polymorphism in the CD14 gene is associated with elevated levels of soluble CD14 but not with IgE or atopic diseases , 2004, Allergy.

[4]  M. Barbouche,et al.  Toll-Like Receptor 2 Arg677Trp Polymorphism Is Associated with Susceptibility to Tuberculosis in Tunisian Patients , 2004, Clinical Diagnostic Laboratory Immunology.

[5]  U. Göbel,et al.  High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR , 2003, Journal of Molecular Medicine.

[6]  D. Golenbock,et al.  Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2 , 2003, Journal of Virology.

[7]  T. Kang,et al.  Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. , 2001, FEMS immunology and medical microbiology.

[8]  D. Schwartz,et al.  Determination of the TLR4 genotype using allele-specific PCR. , 2001, BioTechniques.

[9]  D. Schwartz,et al.  TLR4 mutations are associated with endotoxin hyporesponsiveness in humans , 2000, Nature Genetics.

[10]  P. Holt,et al.  A Polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. , 1999, American journal of respiratory cell and molecular biology.