Fractional exhaled nitric oxide concentration is increased in asbestosis and pleural plaques

Objective and background:  Asbestos exposure induces generation of reactive oxygen and nitrogen species. Nitric oxide is involved in asbestos‐related lung toxicity in vitro and can be measured non‐invasively in humans in exhaled breath. The authors hypothesized that fractional exhaled nitric oxide concentration (FENO) would be increased in subjects with asbestos‐related lung disorders.

[1]  Dirkje S Postma,et al.  Ongoing airway inflammation in patients with COPD who do not currently smoke , 1999, Chest.

[2]  K. Rabe,et al.  Exhaled nitric oxide in COPD: glancing through a smoke screen , 1999, Thorax.

[3]  R. D. du Bois,et al.  Exhaled nitric oxide is increased in active fibrosing alveolitis. , 1999, Chest.

[4]  P. Barnes,et al.  Exhaled carbon monoxide in childhood asthma. , 1999, The Journal of pediatrics.

[5]  R. Järvenpää,et al.  Extended exhaled NO measurement differentiates between alveolar and bronchial inflammation. , 2001, American journal of respiratory and critical care medicine.

[6]  P. Barnes,et al.  Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force. , 1997, The European respiratory journal.

[7]  S. Kharitonov,et al.  Exhaled and nasal nitric oxide measurements : recommendations , 1997 .

[8]  D. Yates,et al.  Passive smoke inhalation decreases exhaled nitric oxide in normal subjects. , 2001, American journal of respiratory and critical care medicine.

[9]  S. Weitzman,et al.  The molecular basis of asbestos induced lung injury , 1999, Thorax.

[10]  D. Yates,et al.  Acute and chronic effects of cigarette smoking on exhaled nitric oxide. , 1995, American journal of respiratory and critical care medicine.

[11]  A. Churg,et al.  Mechanisms in the pathogenesis of asbestosis and silicosis. , 1998, American journal of respiratory and critical care medicine.

[12]  R. Hancox,et al.  The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. , 2001, American journal of respiratory and critical care medicine.

[13]  Makh.  American Thoracic Society. Medical Section of the American Lung Association: The diagnosis of nonmalignant diseases related to asbestos. , 1986, The American review of respiratory disease.

[14]  T. McLoud,et al.  The radiographic pleural abnormalities in asbestos exposure: relationship to physiologic abnormalities. , 1988, Journal of thoracic imaging.

[15]  D. Stevenson,et al.  Exhaled carbon monoxide in asthma. , 2000, The Journal of pediatrics.

[16]  P. Barnes,et al.  Exhaled markers of pulmonary disease. , 2001, American journal of respiratory and critical care medicine.

[17]  E. Ihre,et al.  Exhaled carbon monoxide is not elevated in patients with asthma or cystic fibrosis , 2002, European Respiratory Journal.

[18]  L. Fabbri,et al.  Effect of smoking cessation on airway inflammation in chronic bronchitis. , 1995, American journal of respiratory and critical care medicine.

[19]  V. Kinnula.  Oxidant and antioxidant mechanisms of lung disease caused by asbestos fibres. , 1999, The European respiratory journal.

[20]  P. J. Barnes,et al.  Increased nitric oxide in exhaled air of asthmatic patients , 1994, The Lancet.