Lung Nodule Segmentation Based on Convolutional Neural Networks Using Multi-orientation and Patchwise Mechanisms

Image segmentation is used in several knowledge domains, such as medicine, biology, remote sensing, industrial automation, surveillance and security. More specifically, image segmentation plays a crucial role in various medical imaging applications, as an important part of clinical diagnosis. Deep learning techniques have recently benefited medical image segmentation and classification tasks. In this work, we have explored the use of Convolutional Neural Networks (CNN) for lung nodule segmentation using multi-orientation and patchwise mechanisms. Experiments conducted on the public LIDC-IRI dataset demonstrate that our results were able to reduce the number of false negatives, which is important in this task. High segmentation rates were achieved when compared to medical specialists.

[1]  Rolf Adams,et al.  Seeded Region Growing , 1994, IEEE Trans. Pattern Anal. Mach. Intell..

[2]  Max A. Viergever,et al.  Deep Learning for Multi-Task Medical Image Segmentation in Multiple Modalities , 2016, MICCAI.

[3]  Hélio Pedrini,et al.  Lung Nodule Classification Based on Deep Convolutional Neural Networks , 2016, CIARP.

[4]  Zhenyu Liu,et al.  Central focused convolutional neural networks: Developing a data-driven model for lung nodule segmentation , 2017, Medical Image Anal..

[5]  Gregory G. Slabaugh,et al.  Automatic Graph Cut Segmentation of Lesions in CT Using Mean Shift Superpixels , 2010, Int. J. Biomed. Imaging.

[6]  A. Jemal,et al.  Cancer statistics, 2016 , 2016, CA: a cancer journal for clinicians.

[7]  Aly A. Farag,et al.  A Novel Approach for Lung Nodules Segmentation in Chest CT Using Level Sets , 2013, IEEE Transactions on Image Processing.

[8]  Zhenyu Liu,et al.  A multi-view deep convolutional neural networks for lung nodule segmentation , 2017, 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[9]  Geoffrey E. Hinton Deep belief networks , 2009, Scholarpedia.

[10]  Paulo Amorim,et al.  InVesalius: An Interactive Rendering Framework for Health Care Support , 2015, ISVC.

[11]  A. Bankier,et al.  2D or 3D measurements of pulmonary nodules: preliminary answers and more open questions. , 2018, Journal of thoracic disease.

[12]  Rodrigo Minetto,et al.  Satellite Image Segmentation Using Wavelet Transforms Based on Color and Texture Features , 2008, ISVC.

[13]  Adam Coates,et al.  Deep Voice: Real-time Neural Text-to-Speech , 2017, ICML.

[14]  Yoshua Bengio,et al.  Generative Adversarial Nets , 2014, NIPS.

[15]  Thomas Brox,et al.  U-Net: Convolutional Networks for Biomedical Image Segmentation , 2015, MICCAI.

[16]  Geoffrey E. Hinton,et al.  Deep Learning , 2015, Nature.

[17]  William Robson Schwartz,et al.  Color Textured Image Segmentation Based on Spatial Dependence Using 3D Co-occurrence Matrices and Markov Random Fields , 2007 .

[18]  Ulas Bagci,et al.  Semi-Supervised Multi-Task Learning for Lung Cancer Diagnosis , 2018, 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[19]  A. Jemal,et al.  Cancer statistics, 2017 , 2017, CA: a cancer journal for clinicians.

[20]  Jonathan Wu,et al.  Lung Cancer Tumor Region Segmentation Using Recurrent 3D-DenseUNet , 2018, TIA@MICCAI.

[21]  Rebecca L. Siegel Mph,et al.  Cancer statistics, 2016 , 2016 .

[22]  Richard C. Pais,et al.  The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): a completed reference database of lung nodules on CT scans. , 2011, Medical physics.

[23]  Paulo Amorim,et al.  Medical Imaging for Three-Dimensional Computer-Aided Models , 2018 .

[24]  Carl de Boor,et al.  A Practical Guide to Splines , 1978, Applied Mathematical Sciences.

[25]  Geoffrey E. Hinton,et al.  ImageNet classification with deep convolutional neural networks , 2012, Commun. ACM.

[26]  Xiao-Lei Zhang,et al.  Deep Belief Networks Based Voice Activity Detection , 2013, IEEE Transactions on Audio, Speech, and Language Processing.

[27]  R. Thornhill,et al.  Role of quantitative computed tomography texture analysis in the differentiation of primary lung cancer and granulomatous nodules. , 2016, Quantitative imaging in medicine and surgery.

[28]  A. Madabhushi,et al.  An integrated segmentation and shape‐based classification scheme for distinguishing adenocarcinomas from granulomas on lung CT , 2017, Medical physics.

[29]  A. Bankier,et al.  Lung Adenocarcinoma Manifesting as Pure Ground‐Glass Nodules: Correlating CT Size, Volume, Density, and Roundness with Histopathologic Invasion and Size , 2017, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[30]  Fucang Jia,et al.  Automatic Segmentation of Liver Tumor in CT Images with Deep Convolutional Neural Networks , 2015 .

[31]  Jin Mo Goo,et al.  Recommendations for Measuring Pulmonary Nodules at CT: A Statement from the Fleischner Society. , 2017, Radiology.

[32]  Jamshid Dehmeshki,et al.  Shape-Based Computer-Aided Detection of Lung Nodules in Thoracic CT Images , 2009, IEEE Transactions on Biomedical Engineering.

[33]  Wolfram Burgard,et al.  The limits and potentials of deep learning for robotics , 2018, Int. J. Robotics Res..

[34]  Giovanni Montana,et al.  Deep neural networks for anatomical brain segmentation , 2015, 2015 IEEE Conference on Computer Vision and Pattern Recognition Workshops (CVPRW).