Levobupivacaine versus racemic bupivacaine for spinal anesthesia.

Levobupivacaine is the pure S(−)-enantiomer of racemic bupivacaine but is less toxic to the heart and central nervous system. Although it has recently been introduced for routine obstetric and nonobstetric epidural anesthesia, comparative clinical studies on its intrathecal administration are not av

[1]  M. Pinaud,et al.  Intrathecal Anesthesia: Ropivacaine Versus Bupivacaine , 2000, Anesthesia and analgesia.

[2]  P. Frascarolo,et al.  A Comparison of the Electrocardiographic Cardiotoxic Effects of Racemic Bupivacaine, Levobupivacaine, and Ropivacaine in Anesthetized Swine , 2000, Anesthesia and analgesia.

[3]  D. Kopacz,et al.  A Comparison of Epidural Levobupivacaine 0.75% with Racemic Bupivacaine for Lower Abdominal Surgery , 2000, Anesthesia and analgesia.

[4]  A. Markham,et al.  Levobupivacaine , 2000, Drugs.

[5]  D. Burke,et al.  Spinal anesthesia with 0.5% S(-)-bupivacaine for elective lower limb surgery. , 1999, Regional anesthesia and pain medicine.

[6]  S. Kapral,et al.  Cardiovascular effects of 6% hetastarch and lactated Ringer's solution during spinal anesthesia. , 1999, Regional anesthesia and pain medicine.

[7]  M. Checketts,et al.  Comparison of S(-)-Bupivacaine with Racemic (RS)-Bupivacaine in Supraclavicular Brachial Plexus Block , 1999 .

[8]  A. Bader,et al.  Clinical effects and maternal and fetal plasma concentrations of 0.5% epidural levobupivacaine versus bupivacaine for cesarean delivery. , 1999, Anesthesiology.

[9]  R. Gristwood,et al.  Levobupivacaine: a new safer long acting local anaesthetic agent. , 1999, Expert opinion on investigational drugs.

[10]  H. Kehlet,et al.  Levobupivacaine vs bupivacaine as infiltration anaesthesia in inguinal herniorrhaphy. , 1999, British journal of anaesthesia.

[11]  R. Gristwood,et al.  A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers. , 2002, British journal of clinical pharmacology.

[12]  B. Veering,et al.  Cardiovascular and Central Nervous System Effects of Intravenous Levobupivacaine and Bupivacaine in Sheep , 1998, Anesthesia and analgesia.

[13]  J. Bannister,et al.  Extradural S(-)-bupivacaine: comparison with racemic RS-bupivacaine. , 1998, British journal of anaesthesia.

[14]  P. Klein,et al.  Ropivacain zur Spinalanästhesie Eine Dosisfindungsstudie , 1996, Der Anaesthesist.

[15]  A. Burm,et al.  Pharmacokinetics of the enantiomers of bupivacaine following intravenous administration of the racemate. , 1994, British journal of clinical pharmacology.

[16]  R. Caplan,et al.  Incidence and risk factors for side effects of spinal anesthesia. , 1992, Anesthesiology.