Epileptiform activity in children with developmental dysphasia: quantification of discharges in overnight sleep video-EEG.

We present results of analysis of overnight sleep video-EEG in 8 patients with developmental dysphasia and rolandic discharges. We evaluated the incidence of epileptiform discharges (expressed as paroxysmal activity density) at one or more electrodes in different sleep stages in three different periods of the night (after falling asleep, around midnight and before awakening). The difference of paroxysmal activity density was never higher than 21%, indicating that quantifying the discharges in the whole night recording is not necessary. We also showed that two independent foci may differ in the frequency of discharges. We propose a scheme for evaluation of EEG reflecting both frequency and distribution of discharges.

[1]  L. Blason,et al.  Comorbidity of DCD and SLI: Significance of epileptiform activity during sleep. , 2006, Child: care, health and development.

[2]  J. Arends,et al.  Cognitive and behavioral effects of nocturnal epileptiform discharges in children with benign childhood epilepsy with centrotemporal spikes , 2006, Epilepsy & Behavior.

[3]  D. Uluduz,et al.  A Clinical and EEG Study on Idiopathic Partial Epilepsies with Evolution into ESES Spectrum Disorders , 2005, Epilepsia.

[4]  L. Hartelius,et al.  Comorbidity in severe developmental language disorders: Neuropediatric and psychological considerations , 2005, Acta paediatrica.

[5]  H. Doose,et al.  Benign partial epilepsy and related conditions: Multifactorial pathogenesis with hereditary impairment of brain maturation , 1989, European Journal of Pediatrics.

[6]  V. Komarek,et al.  Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism , 2004, European Child & Adolescent Psychiatry.

[7]  D. Duane.  Increased Frequency of Rolandic Spikes in ADHD Children , 2004, Epilepsia.

[8]  Martin H. Schmidt,et al.  Response: Increased Frequency of Rolandic Spikes in ADHD Children , 2004, Epilepsia.

[9]  L. Bergkvist,et al.  Comorbidity in children with severe developmental language disability , 2002, Acta paediatrica.

[10]  F. Cheliout-Heraut,et al.  Anomalies EEG, modifications du sommeil et dysphasies de développement , 1999, Neurophysiologie Clinique/Clinical Neurophysiology.

[11]  W. Whitehouse.  ‘Sleep EEG and developmental dysphasia’ , 1999, Developmental medicine and child neurology.

[12]  C. Billard,et al.  Sleep EEG and developmental dysphasia: lack of a consistent relationship with paroxysmal EEG activity during sleep. , 1995, Neuropediatrics.

[13]  Z. Matějček.  Dyslexie : specifické poruchy čtení. , 1995 .

[14]  Y. Okubo,et al.  Epileptiform EEG Discharges in Healthy Children: Prevalence, Emotional and Behavioral Correlates, and Genetic Influences , 1994, Epilepsia.

[15]  J. Touchon,et al.  Epileptic electroencephalographic abnormalities and developmental dysphasias: A study of 32 patients , 1992, Brain and Development.

[16]  R. Tuchman,et al.  Autistic and dysphasic children. II: Epilepsy. , 1991, Pediatrics.

[17]  F. Laffont,et al.  Two distinct classifications of adult epilepsies: by time of seizures and by sensitivity of the interictal paroxysmal activities to sleep and waking. , 1987, Electroencephalography and clinical neurophysiology.

[18]  A. Gesell,et al.  Manual of developmental diagnosis: The administration and interpretation of the revised Gesell and Amatruda developmental and neurologic examination , 1980 .