论文信息 - Mouse brain fixation to preserve In vivo manganese enhancement for ex vivo manganese‐enhanced MRI

Mouse brain fixation to preserve In vivo manganese enhancement for ex vivo manganese‐enhanced MRI

To develop a tissue fixation method that preserves in vivo manganese enhancement for ex vivo magnetic resonance imaging (MRI). The needs are clear, as conventional in vivo manganese‐enhanced MRI (MEMRI) applied to live animals is time‐limited, hence limited in spatial resolution and signal‐to‐noise ratio (SNR). Ex vivo applications can achieve superior spatial resolution and SNR through increased signal averaging and optimized radiofrequency coil designs. A tissue fixation method that preserves in vivo Mn2+ enhancement postmortem is necessary for ex vivo MEMRI.

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