Gene expression profile analysis: an emerging approach to investigate mechanisms of genotoxicity.
暂无分享,去创建一个
[1] T. Rushmore,et al. Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants. , 1990, The Journal of biological chemistry.
[2] L. Samson,et al. Network responses to DNA damaging agents. , 2004, DNA repair.
[3] J. Kos,et al. Genotoxicity of trivalent chromium in bacterial cells. Possible effects on DNA topology. , 2002, Chemical research in toxicology.
[4] R. Ulrich,et al. Overview of an interlaboratory collaboration on evaluating the effects of model hepatotoxicants on hepatic gene expression. , 2004, Environmental health perspectives.
[5] R. Walmsley,et al. The GreenScreen genotoxicity assay: a screening validation programme. , 2004, Mutagenesis.
[6] Lee Bennett,et al. Gene expression analysis reveals chemical-specific profiles. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.
[7] M. Hofnung,et al. The SOS chromotest: direct assay of the expression of gene sfiA as a measure of genotoxicity of chemicals. , 1982, Biochimie.
[8] M. Bittner,et al. Functional genomics as a window on radiation stress signaling , 2003, Oncogene.
[9] D Brusick,et al. International Commission for Protection Against Environmental Mutagens and Carcinogens. Genotoxicity under extreme culture conditions. A report from ICPEMC Task Group 9. , 1991, Mutation research.
[10] M. B. Grace,et al. Human In vivo Radiation-Induced Biomarkers , 2004, Cancer Research.
[11] A. Fornace,et al. MONITORING HUMAN RADIATION EXPOSURE BY GENE EXPRESSION PROFILING: POSSIBILITIES AND PITFALLS , 2003, Health physics.
[12] Jiri Aubrecht,et al. Differentiating mechanisms of toxicity using global gene expression analysis in Saccharomyces cerevisiae. , 2005, Mutation research.
[13] Margaret Werner-Washburne,et al. The genomics of yeast responses to environmental stress and starvation , 2002, Functional & Integrative Genomics.
[14] M. Karin,et al. Three distinct signalling responses by murine fibroblasts to genotoxic stress , 1996, Nature.
[15] Michael L Bittner,et al. Stress-specific signatures: expression profiling of p53 wild-type and -null human cells , 2005, Oncogene.
[16] A. Fornace,et al. Induction of Cellular p53 Activity by DNA-Damaging Agents and Growth Arrest , 1993, Molecular and cellular biology.
[17] G Horneck,et al. A biosensor for environmental genotoxin screening based on an SOS lux assay in recombinant Escherichia coli cells , 1997, Applied and environmental microbiology.
[18] A. Fornace,et al. Mammalian DNA damage-inducible genes associated with growth arrest and apoptosis. , 1996, Mutation research.
[19] A. Fornace,et al. Induction of stress genes by low doses of gamma rays. , 1999, Radiation research.
[20] Marilyn J. Aardema,et al. Toxicology and genetic toxicology in the new era of "toxicogenomics": impact of "-omics" technologies. , 2002 .
[21] S M Morris,et al. Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells. , 2004, Mutation research.
[22] T Sofuni,et al. ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact. , 1999, Mutation research.
[23] D. Watson,et al. Comparison of gene expression changes induced in mouse and human cells treated with direct‐acting mutagens , 2004, Environmental and molecular mutagenesis.
[24] D. Stone,et al. Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[25] G. Wahl,et al. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. , 1996, Genes & development.
[26] S. Amundson,et al. Gene expression profiles for monitoring radiation exposure. , 2001, Radiation protection dosimetry.
[27] R. Morimoto,et al. Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells. , 1988, Molecular and cellular biology.
[28] Shimon Ulitzur,et al. Identification and Quantification of Toxic Chemicals by Use of Escherichia coli Carryinglux Genes Fused to Stress Promoters , 1998, Applied and Environmental Microbiology.
[29] K. Kinzler,et al. NORF5/HUG1 Is a Component of theMEC1-Mediated Checkpoint Response to DNA Damage and Replication Arrest in Saccharomyces cerevisiae , 1999, Molecular and Cellular Biology.
[30] Michael D Waters,et al. Quality Review Procedures Necessary for Rodent Pathology Databases and Toxicogenomic Studies: The National Toxicology Program Experience , 2002, Toxicologic pathology.
[31] Ronald W. Davis,et al. Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[32] S. Seidel,et al. Identification of transcriptome profiles for the DNA‐damaging agents bleomycin and hydrogen peroxide in L5178Y mouse lymphoma cells , 2003, Environmental and molecular mutagenesis.
[33] B. Ames,et al. Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. , 1973, Proceedings of the National Academy of Sciences of the United States of America.
[34] G. Warnes,et al. Differentiation of DNA reactive and non-reactive genotoxic mechanisms using gene expression profile analysis. , 2004, Mutation research.
[35] D. Botstein,et al. Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. , 2001, Molecular biology of the cell.
[36] George M. Church,et al. Regulatory Networks Revealed by Transcriptional Profiling of Damaged Saccharomyces cerevisiae Cells: Rpn4 Links Base Excision Repair with Proteasomes , 2000, Molecular and Cellular Biology.
[37] L. Samson,et al. Global response of Saccharomyces cerevisiae to an alkylating agent. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[38] U. Lopes,et al. p53-dependent Induction of Apoptosis by Proteasome Inhibitors* , 1997, The Journal of Biological Chemistry.
[39] S. Jackson,et al. Interfaces Between the Detection, Signaling, and Repair of DNA Damage , 2002, Science.
[40] P. Bushel,et al. Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation , 2003, Molecular carcinogenesis.
[41] P. Duerksen-Hughes,et al. A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. , 1998, Carcinogenesis.
[42] Jiri Aubrecht,et al. The utility of DNA microarrays for characterizing genotoxicity. , 2004, Environmental health perspectives.
[43] B. Ames. Carcinogens are mutagens: their detection and classification. , 1973, Environmental health perspectives.
[44] T. Nunoshiba,et al. 'Rec-lac test' for detecting SOS-inducing activity of environmental genotoxic substance. , 1991, Mutation research.
[45] T G Myers,et al. The complexity of radiation stress responses: analysis by informatics and functional genomics approaches. , 1999, Gene expression.
[46] R. Burnett,et al. Regulation of Promoter-CAT Stress Genes in HepG2 Cells by Suspensions of Particles from Ambient Air , 1997 .
[47] J. Ludwig,et al. A yeast-based method for the detection of cyto and genotoxicity. , 2003, Toxicology in vitro : an international journal published in association with BIBRA.
[48] H. Shinagawa,et al. Evaluation of the new system (umu-test) for the detection of environmental mutagens and carcinogens. , 1985, Mutation research.
[49] Lee Bennett,et al. Prediction of compound signature using high density gene expression profiling. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.
[50] Marilyn J Aardema,et al. Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins. , 2004, Mutation research.
[51] S Albertini,et al. Thresholds in genotoxicity responses. , 2000, Mutation research.
[52] Micheline Kirsch-Volders,et al. Indirect mechanisms of genotoxicity. , 2003, Toxicology letters.
[53] P. Duerksen-Hughes,et al. p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing. , 1999, Environmental health perspectives.
[54] M. Bittner,et al. Differential Responses of Stress Genes to Low Dose-Rate ; Irradiation , 2003 .
[55] A. Fornace,et al. Induction of fos RNA by DNA-damaging agents. , 1989, Cancer research.
[56] L. Verschaeve,et al. The VITOTOX test, an SOS bioluminescence Salmonella typhimurium test to measure genotoxicity kinetics. , 1997, Mutation research.
[57] C. Prives,et al. p53: puzzle and paradigm. , 1996, Genes & development.
[58] William Pennie,et al. Toxicogenomics in risk assessment: an overview of an HESI collaborative research program. , 2004, Environmental health perspectives.
[59] J. Trent,et al. Microarrays and toxicology: The advent of toxicogenomics , 1999, Molecular carcinogenesis.
[60] J. Aubrecht,et al. Molecular genotoxicity profiles of apoptosis-inducing vanadocene complexes. , 1999, Toxicology and applied pharmacology.
[61] J. Kleinjans,et al. Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling. , 2004, Carcinogenesis.
[62] A. Vollmer,et al. Stress responsive bacteria: biosensors as environmental monitors. , 2004 .
[63] R. Dunn,et al. Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.
[64] Hook Eb. International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC meeting report no. 3. Is the incidence of Down syndrome increasing? , 1983, Mutation research.
[65] A. Fornace,et al. DNA damage-inducible transcripts in mammalian cells. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[66] W. Morgan,et al. Gene expression profiling after irradiation: Clues to understanding acute and persistent responses? , 2004, Cancer and Metastasis Reviews.
[67] L. Pereira,et al. Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I , 1991, Molecular and cellular biology.
[68] D. Kirkland,et al. Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds. , 2000, Mutation research.
[69] Chang-Woo Song,et al. cDNA microarray gene expression profiling of hydroxyurea, paclitaxel, and p‐anisidine, genotoxic compounds with differing tumorigenicity results , 2003, Environmental and molecular mutagenesis.
[70] A. Fornace,et al. Genotoxic‐Stress‐Response Genes and Growth‐Arrest Genes , 1992, Annals of the New York Academy of Sciences.
[71] D. Botstein,et al. Genomic expression programs in the response of yeast cells to environmental changes. , 2000, Molecular biology of the cell.
[72] E. Pereira,et al. Gene expression profiles in human cells submitted to genotoxic stress. , 2003, Mutation research.
[73] S. Seidel,et al. Profiles of gene expression changes in L5178Y mouse lymphoma cells treated with methyl methanesulfonate and sodium chloride. , 2004, Mutagenesis.
[74] Michael J. Lee,et al. The CAT-Tox (L) Assay: A Sensitive and Specific Measure of Stress-Induced Transcription in Transformed Human Liver Cells , 1995 .
[75] J W Green,et al. A review of the genotoxicity of marketed pharmaceuticals. , 2001, Mutation research.
[76] A. Heguy,et al. Structural and functional analysis of the human metallothionein-IA gene: Differential induction by metal ions and glucocorticoids , 1984, Cell.
[77] A. Fornace,et al. Analysis of the mammalian gadd45 gene and its response to DNA damage. , 1993, The Journal of biological chemistry.
[78] Sally A Amundson,et al. Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress , 1998, Oncogene.
[79] S. Beard,et al. Stress responses to DNA damaging agents in the human colon carcinoma cell line, RKO. , 1996, Mutation research.