Incidence of community-acquired pneumonia and Chlamydia pneumoniae infection: a prospective multicentre study.

This one year prospective multicentre study was designed to determine the incidence of community-acquired pneumonia in adults. It was carried out in primary health care centres and three reference hospitals, located in the 'Maresme' region (Barcelona, Spain) serving a population of 39,733 subjects over 13 years of age. Patients suspected of having contracted community-acquired pneumonia were visited by their family doctors and referred to the three reference hospitals for confirmation of the diagnosis. Patients attending the emergency services of these hospitals were also included. Urine and blood samples were obtained for culture, antigen detection, blood count, serological tests, blood gases and biochemical profile. The diagnosis of community-acquired pneumonia was made in 105 patients. Forty-six patients had an identifiable microbial etiology. Chlamydia pneumoniae was the most common pathogen (16 cases) followed by Streptococcus pneumoniae (13 cases) and Mycoplasma pneumoniae (8 cases). In conclusion; the annual incidence rate of community-acquired pneumonia in adults in this area was 2.6 cases per 1,000 inhabitants and Chlamydia pneumoniae was the most frequent causative pathogen.

[1]  Ellen Jo Baron,et al.  Manual of clinical microbiology , 1975 .

[2]  M. Rytel Counterimmunoelectrophoresis in Diagnosis of Infectious Disease , 1975 .

[3]  T. Marrie,et al.  Community‐Acquired Pneumonia Requiring Hospitalization , 1985, Journal of the American Geriatrics Society.

[4]  T. Marrie,et al.  Pneumonia associated with the TWAR strain of Chlamydia. , 1987, Annals of internal medicine.

[5]  H. Wilkinson,et al.  Indirect immunofluorescence test for serodiagnosis of Legionnaires disease: evidence for serogroup diversity of Legionnaires disease bacterial antigens and for multiple specificity of human antibodies , 1979, Journal of clinical microbiology.

[6]  L. Campbell,et al.  Structural and antigenic analysis of Chlamydia pneumoniae , 1990, Infection and immunity.

[7]  S. Darougar,et al.  Modification of the microimmunofluorescence test to provide a routine serodiagnostic test for chlamydial infection. , 1977, Journal of clinical pathology.

[8]  D. Smith,et al.  Countercurrent immunoelectrophoresis in the diagnosis of systemic diseases caused by Hemophilus infleunzae type b. , 1972, The Journal of pediatrics.

[9]  W. Kapoor,et al.  New and Emerging Etiologies for Community‐Acquired Pneumonia with Implications for Therapy: A Prospective Multicenter Study of 359 Cases , 1990, Medicine.

[10]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[11]  W. Dowdle,et al.  Adult pneumonia in a general hospital. Etiology and host risk factors. , 1972, Archives of internal medicine.

[12]  M. Britton Diagnostic errors discovered at autopsy. , 2009, Acta medica Scandinavica.

[13]  S. Isomura,et al.  Prevalence of Chlamydia pneumoniae in Japan. , 1991, The Journal of infectious diseases.

[14]  P. Saikku,et al.  A NEW RESPIRATORY TRACT PATHOGEN: CHLAMYDIA PNEUMONIAE STRAIN TWAR , 1990, The Journal of infectious diseases.

[15]  S. Darougar,et al.  Prevalence in human beings of antibodies to Chlamydia IOL-207, an atypical strain of chlamydia. , 1986, The Journal of infection.

[16]  J. Sever Application of a microtechnique to viral serological investigations. , 1962, Journal of immunology.

[17]  T. Marrie,et al.  Pneumonia—The Quality of Medical Records Data , 1987, Medical care.

[18]  G. Shires,et al.  Pulmonary response to major injury. , 1974, Archives of surgery.