Analysis of the Influence of Lung Function Decline on Brain Function using Brain Healthcare Quotient

In this paper, we used Brain Healthcare Quotient (BHQ) to analyze the influence of lung function on brain function. A large-scale survey was conducted for the purpose. In the measurement survey, magnetic resonance images were acquired, and BHQ was calculated and used as brain function. As lung function, we measured forced vital capacity (FVC) and calculated forced expiratory volume 1.0 sec (FEV1.0%). As a result of analysis, it became clear that the decrease in FEV1.0% affects GM BHQ and that the decrease in lung function also affects brain function by using BHQ.

[1]  H. Soininen,et al.  Chronic obstructive pulmonary disease and asthma and the risk of mild cognitive impairment and dementia: a population based CAIDE study. , 2013, Current Alzheimer research.

[2]  Jiaxing Zhang,et al.  Reduced Regional Gray Matter Volume in Patients with Chronic Obstructive Pulmonary Disease: A Voxel-Based Morphometry Study , 2013, American Journal of Neuroradiology.

[3]  P. Jones,et al.  Cognitive function in COPD , 2010, European Respiratory Journal.

[4]  K. Nemoto,et al.  MRI-based Brain Healthcare Quotients: A bridge between neural and behavioral analyses for keeping the brain healthy , 2017, PloS one.

[5]  E. Brown,et al.  Relationship between asthma and cognition: the Cooper Center Longitudinal Study , 2013, Allergy.

[6]  Denise C. Park,et al.  Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.

[7]  T. Mosley,et al.  Association of lung function with cognitive decline and dementia: the Atherosclerosis Risk in Communities (ARIC) Study , 2011, European journal of neurology.

[8]  K. Kokubun,et al.  Association of Fatigue and Stress With Gray Matter Volume , 2018, Front. Behav. Neurosci..

[9]  D. Devilbiss,et al.  Aligning strategies for using EEG as a surrogate biomarker: a review of preclinical and clinical research. , 2011, Biochemical pharmacology.

[10]  G. Sachs,et al.  Impact of chronic obstructive pulmonary disease (COPD) on attention functions. , 2010, Respiratory medicine.