Microdialysis system for continuous glucose monitoring

A microdialysis system for continuous glucose monitoring has been developed. The system has been optimized for in vivo applications. All the components have been miniaturized to get a small wearable device. It consists of a small gas driven syringe pump, a microdialysis sampling stage, a specially developed silicon flow-through sensor chip and the electronics. Integrated on the sensor chip are the glucose sensor elements together with a system of capillaries and flow channels. Each process step of the chip fabrication has been designed as a full wafer process to achieve mass-production compatibility. The total system performance is demonstrated by in vitro measurements taken from human serum and glucose standard solutions.