Chinese expert consensus on clinical use of non-invasive airway inflammation assessment in bronchial asthma.

The most essential pathological change of bronchial asthma (hereinafter referred to as asthma) is chronic airway inflammation. The severity of airway inflammation is closely associated with airway hyperresponsiveness (AHR), which is the origin of the clinical symptoms (1). Therefore, the assessment of airway inflammation, particularly by noninvasive methods, is of great significance to understand the pathophysiological characteristics of asthma, to guide the management and to achieve better overall control of asthma (2).

[1]  P. Gibson,et al.  Full blood count parameters for the detection of asthma inflammatory phenotypes , 2014, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[2]  Jiangtao Lin [To achieve optimum asthma control is the core of implementing effective asthma management]. , 2014, Zhonghua nei ke za zhi.

[3]  I. Pavord,et al.  Current evidence and future research needs for FeNO measurement in respiratory diseases. , 2014, Respiratory medicine.

[4]  Ghada Saad Abd El-Motaleb,et al.  Study of urinary leukotriene E4 levels in children with acute asthma , 2014, International journal of general medicine.

[5]  C. Porsbjerg,et al.  Predictors of neutrophilic airway inflammation in young smokers with asthma , 2014, The Journal of asthma : official journal of the Association for the Care of Asthma.

[6]  N. Hanania,et al.  Periostin, a novel biomarker of TH2-driven asthma , 2014, Current opinion in pulmonary medicine.

[7]  A. Fortuna,et al.  Exhaled Nitric Oxide Fraction as an Add-On to ACQ-7 for Not Well Controlled Asthma Detection , 2013, PloS one.

[8]  H. Ortega,et al.  Blood eosinophil count is a useful biomarker to identify patients with severe eosinophilic asthma. , 2013, Annals of the American Thoracic Society.

[9]  C. Morris Arginine and asthma. , 2013, Nestle Nutrition Institute workshop series.

[10]  A. Zwinderman,et al.  Severe adult-onset asthma: A distinct phenotype. , 2013, The Journal of allergy and clinical immunology.

[11]  M. O. Bradley,et al.  S-Nitrosoglutathione Reductase Inhibition Regulates Allergen-Induced Lung Inflammation and Airway Hyperreactivity , 2013, PloS one.

[12]  J. Donohue,et al.  Exhaled nitric oxide to predict corticosteroid responsiveness and reduce asthma exacerbation rates. , 2013, Respiratory medicine.

[13]  A. Lowe,et al.  Exhaled breath condensate in pediatric asthma: Promising new advance or pouring cold water on a lot of hot air? A systematic review , 2013, Pediatric pulmonology.

[14]  R. Panettieri,et al.  Asthma in the elderly: the role of exhaled nitric oxide measurements. , 2012, Respiratory medicine.

[15]  T. Mahr,et al.  Inflammometry in pediatric asthma: a review of fractional exhaled nitric oxide in clinical practice. , 2013, Allergy and asthma proceedings.

[16]  J. Castro‐Rodriguez,et al.  Fractional Exhaled Nitric Oxide Has a Good Correlation with Asthma Control and Lung Function in Latino Children with Asthma , 2013, The Journal of asthma : official journal of the Association for the Care of Asthma.

[17]  B. Lipworth,et al.  Inhaled corticosteroid dose response using domiciliary exhaled nitric oxide in persistent asthma: the FENOtype trial. , 2012, Chest.

[18]  L. Mcgarvey,et al.  The utility of fractional exhaled nitric oxide suppression in the identification of nonadherence in difficult asthma. , 2012, American journal of respiratory and critical care medicine.

[19]  S. Spector,et al.  Is a Single Blood Eosinophil Count a Reliable Marker for “Eosinophilic Asthma?” , 2012, The Journal of asthma : official journal of the Association for the Care of Asthma.

[20]  S. Woo,et al.  Fractional exhaled nitric oxide and forced expiratory flow between 25% and 75% of vital capacity in children with controlled asthma , 2012, Korean journal of pediatrics.

[21]  D. Hui,et al.  Asthma and bronchodilator responsiveness are associated with polymorphic markers of ARG1, CRHR2 and chromosome 17q21 , 2012, Pharmacogenetics and genomics.

[22]  D. Taylor Advances in the clinical applications of exhaled nitric oxide measurements , 2012, Journal of breath research.

[23]  A. McIvor,et al.  Update on exhaled nitric oxide in pulmonary disease , 2012, Expert review of respiratory medicine.

[24]  Zhenyu Liang,et al.  Correlation between exhaled nitric oxide and lung function,ACQ7 scores in patients with bronchial asthma , 2011 .

[25]  A. H. Maitland‐van der Zee,et al.  Inhaled corticosteroid adherence in paediatric patients: the PACMAN cohort study , 2011, Pharmacoepidemiology and drug safety.

[26]  P. Gibson,et al.  Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial , 2011, The Lancet.

[27]  Margaret W Leigh,et al.  An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. , 2011, American journal of respiratory and critical care medicine.

[28]  W. Crawford,et al.  Elevated exhaled nitric oxide is a clinical indicator of future uncontrolled asthma in asthmatic patients on inhaled corticosteroids. , 2011, The Journal of allergy and clinical immunology.

[29]  S. Hazen,et al.  Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in children. , 2011, The Journal of pediatrics.

[30]  I. Adcock,et al.  Hydrogen peroxide in exhaled breath condensate in patients with asthma: a promising biomarker? , 2011, Chest.

[31]  S. Basu Bioactive eicosanoids: Role of prostaglandin F2α and F2-isoprostanes in inflammation and oxidative stress related pathology , 2010, Molecules and cells.

[32]  C. Sorkness,et al.  Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma. , 2010, The Journal of allergy and clinical immunology.

[33]  W. Busse,et al.  Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. , 2010, American journal of respiratory and critical care medicine.

[34]  Richard J Martin,et al.  Lessons learned from variation in response to therapy in clinical trials. , 2010, The Journal of allergy and clinical immunology.

[35]  J. Cowan,et al.  Effects of steroid therapy on inflammatory cell subtypes in asthma , 2009, Thorax.

[36]  R. Golpe,et al.  Exhaled nitric oxide predicts control in patients with difficult-to-treat asthma , 2009, European Respiratory Journal.

[37]  P. McElduff,et al.  Assessment and Reproducibility of Non-Eosinophilic Asthma Using Induced Sputum , 2009, Respiration.

[38]  J. Szecsenyi,et al.  'Diagnosing Asthma in General Practice with Portable Exhaled Nitric Oxide Measurement – Results of a Prospective Diagnostic Study: FENO ≤ 16 ppb better than FENO ≤ 12 ppb to rule out mild and moderate to severe asthma , 2009, Respiratory Research.

[39]  P. Gibson,et al.  Using fractional exhaled nitric oxide to guide asthma therapy: design and methodological issues for ASthma TReatment ALgorithm studies , 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[40]  J. Szecsenyi,et al.  Diagnosing asthma in general practice with portable exhaled nitric oxide measurement – results of a prospective diagnostic study , 2009, Respiratory research.

[41]  C. Sorkness,et al.  Phenotypic predictors of long-term response to inhaled corticosteroid and leukotriene modifier therapies in pediatric asthma. , 2009, The Journal of allergy and clinical immunology.

[42]  W. Hop,et al.  Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. , 2009, American journal of respiratory and critical care medicine.

[43]  M. Turkalj,et al.  Iron and Ferritin Concentrations in Exhaled Breath Condensate of Children with Asthma , 2009, The Journal of asthma : official journal of the Association for the Care of Asthma.

[44]  C. Porsbjerg,et al.  Inflammatory Subtypes in Asthma are Related to Airway Hyperresponsiveness to Mannitol and Exhaled NO , 2009, The Journal of asthma : official journal of the Association for the Care of Asthma.

[45]  M. Sanak,et al.  Eicosanoids in exhaled breath condensates in the assessment of childhood asthma , 2008, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[46]  P. Gergen,et al.  Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial , 2008, The Lancet.

[47]  K. Zimmer,et al.  Effect of inhaled corticosteroid treatment on exhaled breath condensate leukotriene E(4) in children with mild asthma. , 2008, Allergy and asthma proceedings.

[48]  A. Michils,et al.  Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients , 2008, European Respiratory Journal.

[49]  E. Wouters,et al.  Exhaled nitric oxide and biomarkers in exhaled breath condensate indicate the presence, severity and control of childhood asthma , 2007, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[50]  I. Pavord,et al.  The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. , 2007, American journal of respiratory and critical care medicine.

[51]  R. Arora,et al.  Exhaled nitric oxide levels in military recruits with new onset asthma. , 2006, Allergy and asthma proceedings.

[52]  Ratnawati,et al.  Exhaled breath condensate nitrite/nitrate and pH in relation to pediatric asthma control and exhaled nitric oxide , 2006, Pediatric pulmonology.

[53]  D. Taylor,et al.  Exhaled nitric oxide measurements: clinical application and interpretation , 2006, Thorax.

[54]  A. Woodcock,et al.  Exhaled breath condensate pH and childhood asthma: unselected birth cohort study. , 2006, American journal of respiratory and critical care medicine.

[55]  N. Zamel,et al.  Role of spirometry and exhaled nitric oxide to predict exacerbations in treated asthmatics. , 2006, Chest.

[56]  A. Nicholson,et al.  Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study , 2006, Respiratory research.

[57]  L. Boulet,et al.  Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations , 2006, European Respiratory Journal.

[58]  S. Nishima,et al.  Effect of Inhaled Steroid Therapy on Exhaled Nitric Oxide and Bronchial Responsiveness in Children with Asthma , 2006, The Journal of asthma : official journal of the Association for the Care of Asthma.

[59]  S. Wenzel,et al.  Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthma. , 2005, The Journal of allergy and clinical immunology.

[60]  K. Tokuyama,et al.  Bronchial sensitivity and bronchial reactivity in children with cough variant asthma. , 2005, Chest.

[61]  W. Hop,et al.  Titrating steroids on exhaled nitric oxide in children with asthma: a randomized controlled trial. , 2005, American journal of respiratory and critical care medicine.

[62]  I. Pavord,et al.  The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[63]  J. Cowan,et al.  Exhaled nitric oxide: a predictor of steroid response. , 2005, American journal of respiratory and critical care medicine.

[64]  P. Barnes,et al.  Exhaled 8-isoprostane in childhood asthma , 2005, Respiratory research.

[65]  J. Cowan,et al.  Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. , 2005, The New England journal of medicine.

[66]  N. Wilson,et al.  Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. , 2005, American journal of respiratory and critical care medicine.

[67]  S. Godfrey,et al.  Exhaled nitric oxide in the diagnosis of asthma: comparison with bronchial provocation tests , 2005, Thorax.

[68]  W. Hop,et al.  Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission , 2005, Thorax.

[69]  P. Montuschi,et al.  Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children. , 2004, The Journal of allergy and clinical immunology.

[70]  P. Barnes,et al.  Breath condensate pH in children with cystic fibrosis and asthma: a new noninvasive marker of airway inflammation? , 2004, Chest.

[71]  J. Cowan,et al.  Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. , 2004, American journal of respiratory and critical care medicine.

[72]  M. Corradi,et al.  Leukotrienes and 8-isoprostane in exhaled breath condensate of children with stable and unstable asthma. , 2004, The Journal of allergy and clinical immunology.

[73]  C. Sorkness,et al.  Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. , 2003, The Journal of allergy and clinical immunology.

[74]  P. Montuschi,et al.  Increased exhaled 8-isoprostane in childhood asthma. , 2003, Chest.

[75]  E. Baraldi,et al.  Treatment of concurrent OSA may benefit patients with heart failure , 2003, Thorax.

[76]  G. Verleden,et al.  Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma. , 2003, Chest.

[77]  P. Montuschi,et al.  Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma , 2002, Thorax.

[78]  M. Ennis,et al.  Exhaled nitric oxide correlates with airway eosinophils in childhood asthma , 2002, Thorax.

[79]  Stephen C Lazarus,et al.  Banks CORTICOSTEROIDS FOR PERSISTENT ASTHMA SIGNIFICANT VARIABILITY IN RESPONSE TO INHALED Services , 2022 .

[80]  I. Adcock,et al.  Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. , 2001, American journal of respiratory and critical care medicine.

[81]  R. Hancox,et al.  The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. , 2001, American journal of respiratory and critical care medicine.

[82]  P. Gibson,et al.  Induced sputum eosinophils in the assessment of asthma and chronic cough* , 2000, Respirology.

[83]  M. Griese,et al.  Changes of exhaled nitric oxide during steroid treatment of childhood asthma , 1999, European Respiratory Journal.

[84]  J. Mattes,et al.  NO in exhaled air is correlated with markers of eosinophilic airway inflammation in corticosteroid-dependent childhood asthma. , 1999, The European respiratory journal.

[85]  R. Duranti,et al.  Sputum analysis, bronchial hyperresponsiveness, and airway function in asthma: results of a factor analysis. , 1999, The Journal of allergy and clinical immunology.

[86]  K. Chung,et al.  An inhaled steroid improves markers of airway inflammation in patients with mild asthma. , 1998, The European respiratory journal.

[87]  P. Gibson How to measure airway inflammation: induced sputum. , 1998, Canadian respiratory journal.

[88]  K. Chung,et al.  Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. , 1998, Thorax.

[89]  P. Barnes,et al.  Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force. , 1997, The European respiratory journal.

[90]  Jin Mei-ling Roles of fractional exhaled nitric oxide(FeNO) in the management of bronchial asthma , 2013 .

[91]  M. Ichinose,et al.  Exhaled nitric oxide cutoff values for asthma diagnosis according to rhinitis and smoking status in Japanese subjects. , 2011, Allergology international : official journal of the Japanese Society of Allergology.

[92]  Chen Yu-zh Primary investigation of fractional concentration of exhaled nitric oxide in asthmatic children , 2011 .

[93]  Zhu Ta The Diagnostic Value of the Fractional Exhaled Nitric Oxide for Asthma , 2009 .