Role for a bidentate ribonuclease in the initiation step of RNA interference

NATURE | VOL 409 | 18 JANUARY 2001 | www.nature.com 363 22. Saitoh, S., Takahashi, K. & Yanagida, M. Mis6, a ®ssion yeast inner centromere protein, acts during G1/S and forms specialized chromatin required for equal segregation. Cell 90, 131±143 (1997). 23. Kelly, T. J. et al. The ®ssion yeast cdc18 gene product couples S-phase to start and mitosis. Cell 74, 371± 382 (1993). 24. Fernandez-Sarabia, M. J., McInery, C., Harris, P., Gordon, C. & Fantes, P. The cell cycle genes cdc22 and suc22 of the ®ssion yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase. Mol. Gen. Genet. 238, 241±251 (1993). 25. Lin, L. & Smith, G. R. Transient, meiosis-induced expression of the rec6 and rec12 genes of Schizosaccharomyces pombe. Genetics 136, 769±779 (1994).

[1]  M. O’Donnell,et al.  A model for SOS-lesion-targeted mutations in Escherichia coli , 2001, Nature.

[2]  H. Vaucheret,et al.  AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[3]  J. Erickson,et al.  Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos , 2000, Current Biology.

[4]  A. Bateman,et al.  Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain. , 2000, Trends in biochemical sciences.

[5]  T. Sijen,et al.  Post‐transcriptional gene‐silencing: RNAs on the attack or on the defense? , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

[6]  B. Bass.  Double-Stranded RNA as a Template for Gene Silencing , 2000, Cell.

[7]  P. Sharp,et al.  RNAi Double-Stranded RNA Directs the ATP-Dependent Cleavage of mRNA at 21 to 23 Nucleotide Intervals , 2000, Cell.

[8]  G. Macino,et al.  Transcription: Gene silencing in worms and fungi , 2000, Nature.

[9]  V. Solovyev,et al.  A novel type of RNase III family proteins in eukaryotes. , 2000, Gene.

[10]  T Irimura,et al.  Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase. , 2000, Biochimica et biophysica acta.

[11]  R. Lehmann,et al.  Targeted mRNA degradation by double-stranded RNA in vitro. , 1999, Genes & development.

[12]  S. Jacobsen,et al.  Disruption of an RNA helicase/RNAse III gene in Arabidopsis causes unregulated cell division in floral meristems. , 1999, Development.

[13]  David C. Baulcombe,et al.  A species of small antisense RNA in posttranscriptional gene silencing in plants. , 1999, Science.

[14]  Andrew Fire,et al.  The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans , 1999, Cell.

[15]  A. Nicholson.  Function, mechanism and regulation of bacterial ribonucleases. , 1999, FEMS microbiology reviews.

[16]  P. Sharp,et al.  RNAi and double-strand RNA. , 1999, Genes & development.

[17]  A. Fire,et al.  Double-stranded RNA as a mediator in sequence-specific genetic silencing and co-suppression. , 1998, Trends in genetics : TIG.

[18]  M. Wassenegger,et al.  A model for RNA-mediated gene silencing in higher plants , 1998, Plant Molecular Biology.

[19]  R. Durbin,et al.  Pfam: A comprehensive database of protein domain families based on seed alignments , 1997, Proteins.

[20]  David C. Baulcombe,et al.  RNA as a target and an initiator of post-transcriptional gene silencing in trangenic plants , 1996, Plant Molecular Biology.

[21]  C. Berg,et al.  Homeless is required for RNA localization in Drosophila oogenesis and encodes a new member of the DE-H family of RNA-dependent ATPases. , 1995, Genes & development.

[22]  D. Bouchez,et al.  AGO1 defines a novel locus of Arabidopsis controlling leaf development , 1998, The EMBO journal.

[23]  P. Reich,et al.  [Letters to nature] , 1975, Nature.