p63 Promotes Cell Survival through Fatty Acid Synthase
暂无分享,去创建一个
M. Loda | S. Signoretti | V. Sabbisetti | A. Di Napoli | E. O'regan | M. Ghebremichael | A. Seeley | A. Amato | A. Napoli | E. O'Regan
[1] W. Hahn,et al. Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. , 2009, Journal of the National Cancer Institute.
[2] M. Loda,et al. Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model , 2008, International journal of cancer.
[3] B. Marinari,et al. Claudin-1 Is a p63 Target Gene with a Crucial Role in Epithelial Development , 2008, PloS one.
[4] S. Sinha,et al. A chromatin immunoprecipitation screen in mouse keratinocytes reveals Runx1 as a direct transcriptional target of ΔNp63 , 2008, Journal of cellular biochemistry.
[5] M. Obinata,et al. p51/p63 inhibits ultraviolet B-induced apoptosis via Akt activation , 2008, Oncogene.
[6] J. Menéndez,et al. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis , 2007, Nature Reviews Cancer.
[7] M. Garmyn. Faculty Opinions recommendation of p51/p63 Inhibits ultraviolet B-induced apoptosis via Akt activation. , 2007 .
[8] L. Ruco,et al. Papillary carcinoma of the thyroid: low expression of NCAM (CD56) is associated with downregulation of VEGF‐D production by tumour cells , 2007, The Journal of pathology.
[9] Gerry Melino,et al. ΔNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2 , 2007, Proceedings of the National Academy of Sciences.
[10] F. McKeon,et al. p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia , 2007, Cell.
[11] M. Loda,et al. Gastrointestinal stromal tumours overexpress fatty acid synthase , 2006, The Journal of pathology.
[12] Jason S. Carroll,et al. p63 regulates an adhesion programme and cell survival in epithelial cells , 2006, Nature Cell Biology.
[13] A. Bradley,et al. p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[14] R. Dhir,et al. Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma. , 2006, Human pathology.
[15] Wensheng Yan,et al. GPX2, a Direct Target of p63, Inhibits Oxidative Stress-induced Apoptosis in a p53-dependent Manner* , 2006, Journal of Biological Chemistry.
[16] A. Mills. p63: oncogene or tumor suppressor? , 2006, Current opinion in genetics & development.
[17] L. Ellisen,et al. p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis. , 2006, Cancer cell.
[18] Julian Downward,et al. PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP , 2005, Oncogene.
[19] Ying Wang,et al. FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis , 2005, Oncogene.
[20] M. Loda,et al. p63 regulates commitment to the prostate cell lineage. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[21] T. Roskams,et al. High‐level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB , 2005, Journal of Pathology.
[22] J. Testa,et al. Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells , 2005, Oncogene.
[23] A. Yang,et al. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. , 2005, Cancer cell.
[24] D. Billheimer,et al. IGFBP-3 Is a Direct Target of Transcriptional Regulation by ΔNp63α in Squamous Epithelium , 2005 .
[25] Guojun Wu,et al. DeltaNp63alpha up-regulates the Hsp70 gene in human cancer. , 2005, Cancer research.
[26] Guojun Wu,et al. ΔNp63α Up-Regulates the Hsp70 Gene in Human Cancer , 2005, Cancer Research.
[27] D. Billheimer,et al. IGFBP-3 is a direct target of transcriptional regulation by DeltaNp63alpha in squamous epithelium. , 2005, Cancer research.
[28] T. Golub,et al. Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells , 2004, Cancer Research.
[29] P. Visca,et al. Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma. , 2004, Anticancer research.
[30] J. Menéndez,et al. Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her‐2/neu (erbB‐2) oncogene‐induced malignant transformation , 2004, Molecular carcinogenesis.
[31] M. Loda,et al. Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells. , 2004, Oral oncology.
[32] S. Ropero,et al. Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel me , 2004, International journal of oncology.
[33] R. Poon,et al. How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer? , 2004, Molecular and Cellular Biology.
[34] Jeffrey W. Smith,et al. Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity , 2004, Cancer Research.
[35] A. Mills,et al. p63 is the molecular switch for initiation of an epithelial stratification program. , 2004, Genes & development.
[36] P. Febbo,et al. Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. , 2003, Molecular cancer research : MCR.
[37] Suzuki Toshimitsu,et al. Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[38] S. Chirala,et al. Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[39] J. Pietenpol,et al. The ΔNp63α Phosphoprotein Binds the p21 and 14-3-3σ Promoters In Vivo and Has Transcriptional Repressor Activity That Is Reduced by Hay-Wells Syndrome-Derived Mutations , 2003, Molecular and Cellular Biology.
[40] J. Pietenpol,et al. The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. , 2003, Molecular and cellular biology.
[41] A. Chinnaiyan,et al. Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. , 2003, Cancer research.
[42] C. Cordon-Cardo,et al. Loss of p63 expression is associated with tumor progression in bladder cancer. , 2002, The American journal of pathology.
[43] P. Morin,et al. Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. , 2002, Experimental cell research.
[44] E. Sturgis,et al. Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis. , 2002, Human pathology.
[45] J. Swinnen,et al. Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. , 2002, Cancer research.
[46] C. Cordon-Cardo,et al. p63 expression profiles in human normal and tumor tissues. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[47] M. Loda,et al. Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line. , 2002, Cancer research.
[48] M. Gorospe,et al. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. , 2001, Cancer research.
[49] R Montironi,et al. p63 is a prostate basal cell marker and is required for prostate development. , 2000, The American journal of pathology.
[50] J. Swinnen,et al. Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway , 2000, Oncogene.
[51] A. Yang,et al. Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. , 2000, Cancer research.
[52] S. Chi,et al. Frequent alteration of p63 expression in human primary bladder carcinomas. , 2000, Cancer research.
[53] J. Jen,et al. Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma , 2000, International journal of cancer.
[54] J. Jen,et al. AIS is an oncogene amplified in squamous cell carcinoma. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[55] B. Oskouian. Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism. , 2000, Cancer letters.
[56] C. Townsend,et al. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[57] F. McKeon,et al. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. , 1999, The Journal of investigative dermatology.
[58] Christopher P. Crum,et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development , 1999, Nature.
[59] H. Vogel,et al. p63 is a p53 homologue required for limb and epidermal morphogenesis , 1999, Nature.
[60] Joseph A. DiGiuseppe,et al. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. , 1998, Cancer research.
[61] A. Yang,et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. , 1998, Molecular cell.
[62] Chikashi Ishioka,et al. Cloning and functional analysis of human p51, which structurally and functionally resembles p53 , 1998, Nature Medicine.
[63] Y. Furuya,et al. Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis. , 1997, Anticancer research.
[64] C. Bamberger,et al. A novel protein with strong homology to the tumor suppressor p53 , 1997, Oncogene.
[65] T. Gansler,et al. Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. , 1997, Human pathology.
[66] S. Wakil,et al. Fatty acid synthase, a proficient multifunctional enzyme. , 1989, Biochemistry.
[67] W. J. Dyer,et al. A rapid method of total lipid extraction and purification. , 1959, Canadian journal of biochemistry and physiology.
[68] H. Bolker,et al. THE INCORPORATION OF ACETATE-1-C14 INTO CHOLESTEROL AND FATTY ACIDS BY SURVIVING TISSUES OF NORMAL AND SCORBUTIC GUINEA PIGS , 1956, The Journal of experimental medicine.