Structural mimicry in bacterial virulence

An important mechanism underlying the strategies used by microbial pathogens to manipulate cellular functions is that of functional mimicry of host activities. In some cases, mimicry is achieved through virulence factors that are direct homologues of host proteins. In others, convergent evolution has produced new effectors that, although having no obvious amino-acid sequence similarity to host factors, are revealed by structural studies to display mimicry at the molecular level.

[1]  W. Kabsch,et al.  The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. , 1997, Science.

[2]  J. Galán,et al.  A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion , 1999, Nature.

[3]  J. Bliska,et al.  A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurlum , 1996, Molecular microbiology.

[4]  P. Cossart,et al.  Interactions of Listeria monocytogenes with mammalian cells during entry and actin‐based movement: bacterial factors, cellular ligands and signaling , 1998, The EMBO journal.

[5]  C. E. Stebbins,et al.  Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1. , 2000, Molecular cell.

[6]  K. Schuebel,et al.  S. typhimurium Encodes an Activator of Rho GTPases that Induces Membrane Ruffling and Nuclear Responses in Host Cells , 1998, Cell.

[7]  R. Isberg,et al.  Multiple β 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells , 1990, Cell.

[8]  J. Dixon,et al.  Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. , 1990, Science.

[9]  M. Telepnev,et al.  GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure , 2000, Molecular microbiology.

[10]  J. Galán,et al.  Role of the S. typhimurium actin-binding protein SipA in bacterial internalization. , 1999, Science.

[11]  J. Galán,et al.  Striking a balance: modulation of the actin cytoskeleton by Salmonella. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[12]  P. Cossart,et al.  gC1q‐R/p32, a C1q‐binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes , 2000, The EMBO journal.

[13]  J. Bliska,et al.  Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions , 1997, The EMBO journal.

[14]  R. Isberg,et al.  Bacterial internalization mediated by beta 1 chain integrins is determined by ligand affinity and receptor density. , 1993, The EMBO journal.

[15]  A. Wittinghofer,et al.  How the Pseudomonas aeruginosa ExoS toxin downregulates Rac , 2001, Nature Structural Biology.

[16]  H. Wolf‐Watz,et al.  A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinant , 1993, Nature.

[17]  K. Aktories,et al.  The N-terminal Domain of Pseudomonas aeruginosaExoenzyme S Is a GTPase-activating Protein for Rho GTPases* , 1999, The Journal of Biological Chemistry.

[18]  R. Isberg,et al.  Signaling and invasin-promoted uptake via integrin receptors. , 2000, Microbes and infection.

[19]  J. Galán,et al.  Type III Secretion Machines: Bacterial Devices for Protein Delivery into Host Cells , 1999 .

[20]  T. Honda.  [Bacterial protein toxins]. , 1999, Nihon rinsho. Japanese journal of clinical medicine.

[21]  Harold P. Erickson,et al.  2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region , 1996, Cell.

[22]  R. Hayward,et al.  Direct nucleation and bundling of actin by the SipC protein of invasive Salmonella , 1999, The EMBO journal.

[23]  P. Bjorkman,et al.  Crystal structure of invasin: a bacterial integrin-binding protein. , 1999, Science.

[24]  J. Dixon,et al.  Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease. , 2000, Science.

[25]  R. Rappuoli,et al.  Towards deciphering the Helicobacter pylori cytotoxin , 1999, Molecular microbiology.

[26]  E. Fauman,et al.  Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate , 1994, Nature.

[27]  W. Hardt,et al.  Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell , 2000, Molecular microbiology.

[28]  Maria Fällman,et al.  The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions , 1997, The EMBO journal.

[29]  J. Alouf.  Bacterial protein toxins. An overview. , 2000, Methods in molecular biology.

[30]  W. Hardt,et al.  A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Gregory R. Hoffman,et al.  Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP , 1998, Nature Structural Biology.

[32]  P. Cossart,et al.  Structure of the lnlB leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen L. monocytogenes. , 1999, Molecular cell.

[33]  J. Deisenhofer,et al.  The leucine-rich repeat: a versatile binding motif. , 1994, Trends in biochemical sciences.

[34]  R. Isberg,et al.  The Yersinia pseudotuberculosis invasin protein and human fibronectin bind to mutually exclusive sites on the alpha 5 beta 1 integrin receptor. , 1991, The Journal of biological chemistry.

[35]  P. Sansonetti,et al.  Diversion of cytoskeletal processes by Shigella during invasion of epithelial cells. , 2000, Microbes and infection.

[36]  B. Finlay,et al.  Gut feelings: enteropathogenic E. coli (EPEC) interactions with the host. , 2000, Annual review of cell and developmental biology.

[37]  R. Isberg,et al.  Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells. , 1990, Cell.

[38]  M. Naujokas,et al.  InlB-Dependent Internalization of Listeria Is Mediated by the Met Receptor Tyrosine Kinase , 2000, Cell.

[39]  K. Aktories,et al.  Bacterial protein toxins targeting rho GTPases. , 2000, FEMS microbiology letters.

[40]  A. Wittinghofer,et al.  GTPase-activating proteins: helping hands to complement an active site. , 1998, Trends in biochemical sciences.

[41]  P. Sansonetti,et al.  Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin , 1997, The EMBO journal.

[42]  P. Majerus,et al.  SopB, a protein required for virulence of Salmonella dublin, is an inositol phosphate phosphatase. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[43]  A. Zychlinsky,et al.  A bacterial invasin induces macrophage apoptosis by binding directly to ICE. , 1996, The EMBO journal.

[44]  Katrin Rittinger,et al.  Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue , 1997, Nature.