A synthesis method for automatic handling of inter-patient variability in closed-loop anesthesia

This paper presents a convex-optimization-based technique to obtain PID parameters, used to control the infusion rate of the anesthetic drug propofol. Controller design is based on a set of identified patient models, relating propofol infusion to an EEG-based conciousness index. The main contribution lies in the method automatically taking inter-patient variability into account, i.e., it guarantees robustness (sensitivity peak) and performance (disturbance rejection) over a set of patient models, without the need for manual intervention.