Lipophilicity of regioisomers: A case study on 3(2H)-pyridazinones

[1]  P Mátyus,et al.  Application of neural networks in structure–activity relationships , 1999, Medicinal research reviews.

[2]  P Buchwald,et al.  Octanol-water partition: searching for predictive models. , 1998, Current medicinal chemistry.

[3]  C. Wermuth Search for new lead compounds: The example of the chemical and pharmacological dissection of aminopyridazines , 1998 .

[4]  T. Kappe Synthesis and chemistry of pyridazines functionalized in position 3 and 5 with heteroatoms , 1998 .

[5]  K. Takács-Novák,et al.  Lipophilicity of amphoteric molecules expressed by the true partition coefficient , 1995 .

[6]  N. Bodor,et al.  An extended version of a novel method for the estimation of partition coefficients. , 1992, Journal of pharmaceutical sciences.

[7]  K. Takács-Novák,et al.  Lipophilicity of antibacterial fluoroquinolones , 1992 .

[8]  M. Sato,et al.  Synthesis and biological activity of pyridazinooxazines. , 1982, Chemical & pharmaceutical bulletin.

[9]  M. Sato [Pharmacological studies of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (M73101). (5) Action of M73101 on the central nervous system (author's transl)]. , 1979, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[10]  Han van de Waterbeemd,et al.  Lipophilicity in drug action and toxicology , 1996 .

[11]  W. Meylan,et al.  Atom/fragment contribution method for estimating octanol-water partition coefficients. , 1995, Journal of pharmaceutical sciences.

[12]  John C. Dearden,et al.  The Measurement of Partition Coefficients , 1988 .

[13]  A. Ghose,et al.  Atomic physicochemical parameters for three dimensional structure directed quantitative structure‐activity relationships III: Modeling hydrophobic interactions , 1988 .