Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine‐choline‐deficient diet

Background: Methionine‐choline‐deficient (MCD) diets cause steatohepatitis in rodents and are used to model fatty liver disease in human beings. Recent studies have identified sucrose as a major contributor to MCD‐related liver disease through its ability to promote hepatic de novo lipogenesis.

[1]  A. Suzuki,et al.  Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease , 2010, Hepatology.

[2]  Scott M Turner,et al.  Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis[S] , 2009, Journal of Lipid Research.

[3]  R. Kreis,et al.  Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. , 2009, The American journal of clinical nutrition.

[4]  Wei Zhang,et al.  Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. , 2009, The Journal of clinical investigation.

[5]  A. Feldstein,et al.  Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease , 2009, Journal of Biological Chemistry.

[6]  Jing Ye,et al.  Up-Regulation of Mitochondrial Activity and Acquirement of Brown Adipose Tissue-Like Property in the White Adipose Tissue of Fsp27 Deficient Mice , 2008, PloS one.

[7]  A. Chawla,et al.  Cidea is associated with lipid droplets and insulin sensitivity in humans , 2008, Proceedings of the National Academy of Sciences.

[8]  J. Girard,et al.  Carbohydrate responsive element binding protein and lipid homeostasis , 2008, Current opinion in lipidology.

[9]  E. Parks,et al.  Dietary sugars stimulate fatty acid synthesis in adults. , 2008, The Journal of nutrition.

[10]  S. McCall,et al.  Fructose consumption as a risk factor for non-alcoholic fatty liver disease. , 2008, Journal of hepatology.

[11]  R. Green,et al.  Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet , 2008 .

[12]  Kun Wook Chung,et al.  Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytess⃞s⃞ The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of three figures. Published, JLR Papers in Press, October 18, 2007. , 2008, Journal of Lipid Research.

[13]  G. Gores,et al.  Transcriptional Regulation of Bim by FoxO3A Mediates Hepatocyte Lipoapoptosis* , 2007, Journal of Biological Chemistry.

[14]  S. Kakar,et al.  Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury 1 s⃞ Published, JLR Papers in Press, May 27, 2007. , 2007, Journal of Lipid Research.

[15]  S. McCall,et al.  Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis , 2007, Hepatology.

[16]  M. Chong,et al.  Mechanisms for the acute effect of fructose on postprandial lipemia. , 2007, The American journal of clinical nutrition.

[17]  E. Ravussin,et al.  A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans. , 2006, The American journal of clinical nutrition.

[18]  C. Kendziorski,et al.  Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diets⃞ Published, JLR Papers in Press, September 28, 2006. , 2006, Journal of Lipid Research.

[19]  R. E. Pitas,et al.  Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1 s⃞ Published, JLR Papers in Press, July 8, 2006. , 2006, Journal of Lipid Research.

[20]  Dong Wang,et al.  Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. , 2006, American journal of physiology. Endocrinology and metabolism.

[21]  G. Gores,et al.  Free Fatty Acids Induce JNK-dependent Hepatocyte Lipoapoptosis* , 2006, Journal of Biological Chemistry.

[22]  M. Czaja,et al.  Jnk1 but not jnk2 promotes the development of steatohepatitis in mice , 2006, Hepatology.

[23]  J. Jessurun,et al.  Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. , 2005, The Journal of clinical investigation.

[24]  Takahiro Suzuki,et al.  Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses. , 2004, Gastroenterology.

[25]  H. Cortez‐Pinto,et al.  Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients , 2004, The American Journal of Gastroenterology.

[26]  M. Miyazaki,et al.  Stearoyl-CoA Desaturase 1 Gene Expression Is Necessary for Fructose-mediated Induction of Lipogenic Gene Expression by Sterol Regulatory Element-binding Protein-1c-dependent and -independent Mechanisms* , 2004, Journal of Biological Chemistry.

[27]  D. Vance,et al.  A Choline-deficient Diet in Mice Inhibits neither the CDP-choline Pathway for Phosphatidylcholine Synthesis in Hepatocytes nor Apolipoprotein B Secretion* , 2004, Journal of Biological Chemistry.

[28]  M. Miyazaki,et al.  Regulation of stearoyl-CoA desaturases and role in metabolism. , 2004, Progress in lipid research.

[29]  R. Green,et al.  The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. , 2004, Journal of hepatology.

[30]  G. Gores,et al.  The Caspase Inhibitor IDN-6556 Attenuates Hepatic Injury and Fibrosis in the Bile Duct Ligated Mouse , 2004, Journal of Pharmacology and Experimental Therapeutics.

[31]  D. Ginzinger.  Gene quantification using real-time quantitative PCR: an emerging technology hits the mainstream. , 2002, Experimental hematology.

[32]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[33]  C. Poremba,et al.  Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection , 2001, Hepatology.

[34]  C. Deng,et al.  Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[35]  I. Leclercq,et al.  CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. , 2000, The Journal of clinical investigation.

[36]  S. Wołczyński,et al.  Oxidative stress markers in preovulatory follicular fluid in humans. , 1999, Molecular human reproduction.

[37]  A. Burt,et al.  Diagnosis and interpretation of steatosis and steatohepatitis. , 1998, Seminars in diagnostic pathology.

[38]  H. Jaeschke,et al.  Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and fas‐antibody–induced liver injury , 1998, Hepatology.

[39]  H. Fukuda,et al.  Nutritional and hormonal regulation of mRNA levels of lipogenic enzymes in primary cultures of rat hepatocytes. , 1992, Journal of biochemistry.

[40]  R. Freedland,et al.  Comparison among the lipogenic potential of various substrates in rat hepatocytes: the differential effects of fructose-containing diets on hepatic lipogenesis. , 1989, The Journal of nutrition.

[41]  D. Vance,et al.  The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. , 1988, The Journal of biological chemistry.

[42]  H. Pitot,et al.  Induction of lipogenic enzymes in primary cultures of rat hepatocytes. Relationship between lipogenesis and carbohydrate metabolism. , 2005, European journal of biochemistry.

[43]  J. Folch,et al.  A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.