AlCl 3 ‐Promoted Stereospecific Cloke‐Wilson Rearrangement of Spirocyclopropyl Barbiturates for the Synthesis of Substituted Dihydrofuro[2,3‐ d ]pyrimidines
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[1] Yuhai Tang,et al. Phosphine-Catalyzed Activation of Alkylidenecyclopropanes: Rearrangement to Form Polysubstituted Furans and Dienones. , 2019, Angewandte Chemie.
[2] Minli Zhang,et al. Base-Mediated Tandem 1,6-Addition/Cyclization/Isomerization Reactions between para-Quinone Methides and Benzyl Chlorides: Approaches to Diverse Frameworks at Each Cascade Stage , 2019, Synthesis.
[3] Danqian Xu,et al. Merging catalyst-free synthesis and iodine catalysis: one-pot synthesis of dihydrofuropyrimidines and spirodihydrofuropyrimidine pyrazolones , 2019, RSC advances.
[4] Xixi Song,et al. Chemoselective syntheses of spirodihydrofuryl and spirocyclopropyl barbiturates via cascade reactions of barbiturate-based olefins and acetylacetone. , 2019, Organic & biomolecular chemistry.
[5] M. Kerr,et al. Tandem Cyclopropanation/Vinylogous Cloke-Wilson Rearrangement for the Synthesis of Heterocyclic Scaffolds. , 2018, Organic letters.
[6] Minli Zhang,et al. Diastereoselective Synthesis of Spirobarbiturate-Cyclopropanes through Organobase-Mediated Spirocyclopropanation of Barbiturate-Based Olefins with Benzyl Chlorides , 2018, Synthesis.
[7] Yuhai Tang,et al. Recycling Catalyst as Reactant: A Sustainable Strategy To Improve Atom Efficiency of Organocatalytic Tandem Reactions. , 2018, Organic letters.
[8] Jian Li,et al. Discovery of novel Syk/PDGFR-α/c-Kit inhibitors as multi-targeting drugs to treat rheumatoid arthritis. , 2018, Bioorganic & medicinal chemistry.
[9] J. Vicario,et al. Catalytic Enantioselective Cloke-Wilson Rearrangement. , 2018, Angewandte Chemie.
[10] I. Sorokin,et al. Ring Opening of Donor–Acceptor Cyclopropanes with N-Nucleophiles , 2017, Synthesis.
[11] M. Sodupe,et al. Visible-Light Photocatalytic Intramolecular Cyclopropane Ring Expansion. , 2017, Angewandte Chemie.
[12] Yuhai Tang,et al. Organocatalytic Cloke-Wilson Rearrangement: DABCO-Catalyzed Ring Expansion of Cyclopropyl Ketones to 2,3-Dihydrofurans. , 2017, Organic letters.
[13] S. Kraljević Pavelić,et al. Novel pyrimidine-2,4-dione-1,2,3-triazole and furo[2,3-d]pyrimidine-2-one-1,2,3-triazole hybrids as potential anti-cancer agents: Synthesis, computational and X-ray analysis and biological evaluation. , 2017, European journal of medicinal chemistry.
[14] C. Eigenbrot,et al. 4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase. , 2016, Bioorganic & medicinal chemistry letters.
[15] A. N. Vereshchagin,et al. Stereoselective synthesis of medicinally relevant furo[2,3-d]pyrimidine framework by thermal rearrangement of spirocyclic barbiturates , 2015 .
[16] A. Köhn,et al. Non-decarbonylative photochemical versus thermal activation of Bu4N[Fe(CO)3(NO)] – the Fe-catalyzed Cloke–Wilson rearrangement of vinyl and arylcyclopropanes , 2015, Chemical science.
[17] A. Pałasz,et al. In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications. , 2015, European journal of medicinal chemistry.
[18] M. Kerr,et al. Carbocycles from donor-acceptor cyclopropanes. , 2015, Organic & biomolecular chemistry.
[19] P. Wei,et al. Five-membered heteroaromatic ring fused-pyrimidine derivatives: design, synthesis, and hedgehog signaling pathway inhibition study. , 2014, Bioorganic & medicinal chemistry letters.
[20] D. Werz,et al. A new golden age for donor-acceptor cyclopropanes. , 2014, Angewandte Chemie.
[21] Stefan France,et al. Intramolecular donor-acceptor cyclopropane ring-opening cyclizations. , 2014, Chemical Society reviews.
[22] Michelle C. Schaeffer,et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. , 2013, ACS medicinal chemistry letters.
[23] M. Kerr,et al. γ-Substituted butanolides from cyclopropane hemimalonates: an expedient synthesis of natural (R)-dodecan-4-olide. , 2013, Organic letters.
[24] H. Hsieh,et al. Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor. , 2013, Journal of medicinal chemistry.
[25] P. Lyu,et al. Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors. , 2013, Journal of medicinal chemistry.
[26] L. Hadjiarapoglou,et al. Fused dihydrofurans from the one-pot, three-component reaction of 1,3-cyclohexanedione, iodobenzene diacetate and alkenes , 2013 .
[27] I. Namboothiri,et al. Synthesis of fused bromofurans via Mg-mediated dibromocyclopropanation of cycloalkanone-derived chalcones and Cloke-Wilson rearrangement. , 2013, The Journal of organic chemistry.
[28] David Y-K Chen,et al. Recent advances in the total synthesis of cyclopropane-containing natural products. , 2012, Chemical Society reviews.
[29] S. Sturla,et al. Chemistry and biology of acylfulvenes: sesquiterpene-derived antitumor agents. , 2012, Chemical reviews.
[30] C. Ly,et al. Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine. , 2011, Journal of medicinal chemistry.
[31] D. Werz,et al. Ring-enlargement reactions of donor-acceptor-substituted cyclopropanes: which combinations are most efficient? , 2011, Organic letters.
[32] Y. Maeda,et al. Rational design of 4-amino-5,6-diaryl-furo[2,3-d]pyrimidines as potent glycogen synthase kinase-3 inhibitors. , 2008, Bioorganic & medicinal chemistry letters.
[33] J. Balzarini,et al. Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines. , 2007, Journal of Medicinal Chemistry.
[34] A. de Meijere,et al. Natural occurrence, syntheses, and applications of cyclopropyl-group-containing alpha-amino acids. 1. 1-aminocyclopropanecarboxylic acid and other 2,3-methanoamino acids. , 2007, Chemical reviews.
[35] E. De Clercq,et al. Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives. , 2007, Journal of medicinal chemistry.
[36] Jeffrey S. Johnson,et al. Nickel-catalyzed rearrangement of 1-acyl-2-vinylcyclopropanes. A mild synthesis of substituted dihydrofurans. , 2006, Organic letters.
[37] D. Green,et al. Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity. , 2005, Bioorganic & medicinal chemistry.
[38] Yibin Zeng,et al. Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. , 2004, Journal of medicinal chemistry.
[39] Yibin Zeng,et al. Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. , 2004, Journal of medicinal chemistry.
[40] R. Zimmer,et al. Donor-acceptor-substituted cyclopropane derivatives and their application in organic synthesis. , 2003, Chemical reviews.
[41] R. Balamurugan,et al. Silicon-assisted ring opening of donor-acceptor substituted cyclopropanes. An expedient entry to substituted dihydrofurans. , 2001, Organic letters.
[42] J. T. Erichsen,et al. Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain. , 2000, Journal of medicinal chemistry.
[43] V. Cody,et al. Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines. , 1998, Journal of medicinal chemistry.
[44] T. Hudlický,et al. Use of cyclopropanes and their derivatives in organic synthesis , 1989 .
[45] E. Taylor,et al. Intramolecular Diels-Alder reactions of 1,2,4-triazines. Synthesis of condensed pyrimidines , 1987 .
[46] G. Hitchings,et al. Studies on Condensed Pyrimidine Systems. VIII (1). The 5,6-Dihydrofuro[2,3-d]Pyrimidine Ring System , 1951 .
[47] C. L. Wilson. Reactions of Furan Compounds. VII. Thermal Interconversion of 2,3-Dihydrofuran and Cyclopropane Aldehyde1 , 1947 .
[48] J. Cloke. THE FORMATION OF PYRROLINES FROM GAMMA-CHLOROPROPYL AND CYCLOPROPYL KETIMINES1 , 1929 .