Correlation of clivoaxial angle to skeletal malocclusions: A prescreening for future risk of neurodegenerative disorders

Objectives: To find out if there exists any correlation between clivoaxial angle (CXA) and skeletal malocclusions. Materials and Methods: Lateral cephalograms of 33 filipino patients equally divided in three types of skeletal malocclusions were traced, and cephalometric parameters CXA, BaSN, ANB, SNMPA, FMA, MMPA, and Y-axis were traced. Data underwent bivariate correlation and curve estimation analysis in SPSS 17.0 statistical software at confidence interval of 95% and 0.05 significance level. Results: A highly significant (P = 0.003) strong negative correlation was revealed in Class III patients between CXA and BaSN. Conclusion: Class III patients seem to have higher chances of craniocervical junction anomalies and thus might be at risk of developing neurodegenerative disorders in future.

[1]  M. Flanagan The Role of the Craniocervical Junction in Craniospinal Hydrodynamics and Neurodegenerative Conditions , 2015, Neurology research international.

[2]  B. Jayan,et al.  Cervical vertebral anomalies in patients with obstructive sleep apnea , 2015 .

[3]  T. Ladner,et al.  Posterior odontoid process angulation in pediatric Chiari I malformation: an MRI morphometric external validation study. , 2015, Journal of neurosurgery. Pediatrics.

[4]  L. Shah,et al.  Estimation of odontoid process posterior inclination, odontoid height, and pB-C2 line in the adult population. , 2014, Journal of neurosurgery. Spine.

[5]  A. Vaccaro,et al.  Acute Whiplash: Clinical and Finite Element Analysis , 2013 .

[6]  N. Sousa,et al.  Blood–brain-barriers in aging and in Alzheimer’s disease , 2013, Molecular Neurodegeneration.

[7]  R. Botelho,et al.  Angular craniometry in craniocervical junction malformation , 2013, Neurosurgical Review.

[8]  R. Damadian,et al.  The possible role of cranio-cervical trauma and abnormal CSF hydrodynamics in the genesis of multiple sclerosis. , 2011, Physiological chemistry and physics and medical NMR.

[9]  E. Benzel,et al.  Deformative stress associated with an abnormal clivo-axial angle: A finite element analysis , 2010, Surgical neurology international.

[10]  Douglas H. Smith,et al.  Mechanical breaking of microtubules in axons during dynamic stretch injury underlies delayed elasticity, microtubule disassembly, and axon degeneration , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[11]  Hayder hammadi abdulameer حيدر حمادي عبد الامير MORPHOMETRIC ANALYSIS OF ODONTOID PROCESS , 2010 .

[12]  A. Isla Guerrero,et al.  Malformations of the craniocervical junction (chiari type I and syringomyelia: classification, diagnosis and treatment) , 2009, BMC musculoskeletal disorders.

[13]  S. Faro,et al.  Evaluation of platybasia with MR imaging. , 2005, AJNR. American journal of neuroradiology.

[14]  L. Massimi,et al.  Intracranial pressure monitoring in children with single suture and complex craniosynostosis: a review , 2005, Child's Nervous System.

[15]  A. Lau,et al.  Vulnerability of Central Neurons to Secondary Insults after In Vitro Mechanical Stretch , 2004, The Journal of Neuroscience.

[16]  H. Vinters,et al.  Hydrocephalus with cerebral aqueductal dysgenesis and craniofacial anomalies , 2004, Acta Neuropathologica.

[17]  R. Tubbs,et al.  Inclination of the odontoid process in the pediatric Chiari I malformation. , 2003, Journal of neurosurgery.

[18]  田嶋 緑,et al.  Skull base and calvarial deformities : association with intracranial changes in craniofacial syndromes , 2000 .

[19]  W. K. Chong,et al.  The beaten copper cranium: a correlation between intracranial pressure, cranial radiographs, and computed tomographic scans in children with craniosynostosis. , 1996, Neurosurgery.

[20]  P. Waite The cranial base in obstructive sleep apnea , 1995 .

[21]  F. Bookstein,et al.  A comparative cephalometric study of the cranial base in craniofacial anomalies: Part I: Tensor analysis. , 1985, The Cleft palate journal.

[22]  Chamberlain We Basilar Impression (Platybasia): A Bizarre Developmental Anomaly of the Occipital Bone and Upper Cervical Spine with Striking and Misleading Neurologic Manifestations * , 1939 .