In chromatography, the limit of detection (LOD), as conventionally defined, becomes worse with increased retention due to hand broadening for constant injected quantity and constant analytical detector sensitivity. A method is presented that overcomes this limitation, providing better LOD values independent of chromatographic band broadening effects. This is based on an integration procedure that is simple to implement. A LOD enhancement ratio of roughly 5 to 20 can be obtained for a typical chromatographic system. The method has general applicability for any analytical method in which noise is uncorrelated and an analytical signal is correlated along an abscissa. Examples of areas of application include chromatography, spectral scanning measurements, flow injection analysis, sample injection coupled to atomic absorption spectrometry, and nuclear magnetic resonance. 9 references, 3 figures, 2 tables.
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