Cloud service of analyzing virus data: A case study for Norovirus

Cloud computing, an emerging Internet-based development provides various platform and software services has become a significant issue. Many bioinformatics tools developed based on the Internet for biologists without reconstructing the whole software in the local system. Therefore, bioinformatics as a service is a new significant demand of cloud computing that integrates the bioinformatics tools to cloud platform to provide more efficient bio-computing services. In this paper, we propose a virus analysis service on the cloud. Norovirus is used as case study for this service. The result demonstrates that the proposed cloud service is able to be easily used to analyze virus data by using remote computing resources.

[1]  E. Myers,et al.  Basic local alignment search tool. , 1990, Journal of molecular biology.

[2]  H. Virgin,et al.  Mouse Norovirus Replication Is Associated with Virus-Induced Vesicle Clusters Originating from Membranes Derived from the Secretory Pathway , 2009, Journal of Virology.

[3]  M. Schatz,et al.  Searching for SNPs with cloud computing , 2009, Genome Biology.

[4]  T. Kanda,et al.  Identification of Monomorphic and Divergent Haplotypes in the 2006-2007 Norovirus GII/4 Epidemic Population by Genomewide Tracing of Evolutionary History , 2008, Journal of Virology.

[5]  Laura J. White,et al.  Norwalk Virus Open Reading Frame 3 Encodes a Minor Structural Protein , 2000, Journal of Virology.

[6]  José A. B. Fortes,et al.  CloudBLAST: Combining MapReduce and Virtualization on Distributed Resources for Bioinformatics Applications , 2008, 2008 IEEE Fourth International Conference on eScience.

[7]  T. Ando,et al.  Genetic classification of "Norwalk-like viruses.. , 2000, The Journal of infectious diseases.

[8]  Tomoyuki N. Tanaka,et al.  Genetic and antigenic diversity among noroviruses. , 2006, The Journal of general virology.

[9]  B. Noble,et al.  On certain integrals of Lipschitz-Hankel type involving products of bessel functions , 1955, Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences.

[10]  T. Oka,et al.  Coexistence of Multiple Genotypes, Including Newly Identified Genotypes, in Outbreaks of Gastroenteritis Due to Norovirus in Japan , 2004, Journal of Clinical Microbiology.

[11]  A. M. Hutson,et al.  The 3′ End of Norwalk Virus mRNA Contains Determinants That Regulate the Expression and Stability of the Viral Capsid Protein VP1: a Novel Function for the VP2 Protein , 2003, Journal of Virology.

[12]  J. Thompson,et al.  CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. , 1994, Nucleic acids research.

[13]  M K Estes,et al.  Norwalk virus genome cloning and characterization , 1990, Science.

[14]  T. Gojobori,et al.  Phylogenetic analysis of the complete genome of 18 Norwalk-like viruses. , 2002, Virology.

[15]  Miguel Correia,et al.  Making Hadoop MapReduce Byzantine Fault-Tolerant , 2010, DSN 2010.