Realtime control of multiple-focus phased array heating patterns based on noninvasive ultrasound thermography

We present results from realtime feedback control of single- and multiple-focus phased array heating patterns based on ultrasound thermography. The results illustrate several important aspects of realtime control of phased array heating patterns as they are envisioned to be used in noninvasive, image-guided thermal therapy applications. First, complex, multiple-focus heating patterns require multi-point, noninvasive temperature feedback that may not be easily available using thermocouple or other invasive proibes. Second, multiple-focus pattern synthesis must be optimized to maintain the highest efficiency of the phased array driver in order to achieve the control objectives. This has led to the development of a dynamic power reallocation algorithm for realtime management of the power share of each focus accoring to maximize its heating rate. Third, realtime integration between the feedback thermography and array driver control with high spatial and temporal resolution is necessary, especially for short exposures used in ablative treatments. These aspects are well illustrated by the results shown: 1) realtime thermography at frame rates up to 100 fps, 2) realtime multiple-focus pattern resynthesis with update rates up to 1000 patterns per second, and 3) an intelligent dynamic power reallocation scheme to distribute the available driving power according to the collective needs of the individual foci in the multiple-focus heating patterns. Without this dynamic power reallocation, the standard multiple-focus pattern synthesis may produce low-efficiency driving patterns that may fail to achieve the control objective at the some or all control points in the heating pattern.

[1]  T. Uchida,et al.  Transrectal high‐intensity focused ultrasound for the treatment of localized prostate cancer: Eight‐year experience , 2009, International journal of urology : official journal of the Japanese Urological Association.

[2]  Munther A. Dahleh,et al.  Control system for an MRI compatible intracavitary ultrasound array for thermal treatment of prostate disease. , 2001, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[3]  C. Cain,et al.  Experimental evaluation of a prototype cylindrical section ultrasound hyperthermia phased-array applicator , 1991, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[4]  P. VanBaren,et al.  Ultrasound surgery: comparison of strategies using phased array systems , 1996, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[5]  Rares Salomir,et al.  Automatic temperature control for MR‐guided interstitial ultrasound ablation in liver using a percutaneous applicator: Ex vivo and in vivo initial studies , 2010, Magnetic resonance in medicine.

[6]  C.A. Cain,et al.  Multiple-focus ultrasound phased-array pattern synthesis: optimal driving-signal distributions for hyperthermia , 1989, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[7]  Jeffrey C Bamber,et al.  Fundamental limitations of noninvasive temperature imaging by means of ultrasound echo strain estimation. , 2002, Ultrasound in medicine & biology.

[8]  Bruno Quesson,et al.  Improved Volumetric MR-HIFU Ablation by Robust Binary Feedback Control , 2010, IEEE Transactions on Biomedical Engineering.

[9]  Eduardo G Moros,et al.  In vivo change in ultrasonic backscattered energy with temperature in motion-compensated images , 2008, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[10]  Bernhard Walter,et al.  First analysis of the long-term results with transrectal HIFU in patients with localised prostate cancer. , 2008, European urology.

[11]  D. P. Atherton,et al.  An analysis package comparing PID anti-windup strategies , 1995 .

[12]  Emad S Ebbini,et al.  Dual-Mode Ultrasound Phased Arrays for Image-Guided Surgery , 2006, Ultrasonic imaging.

[13]  P. VanBaren,et al.  Noninvasive real-time multipoint temperature control for ultrasound phased array treatments , 1996, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[14]  S. Yoshizawa,et al.  Coagulation of Large Regions by Creating Multiple Cavitation Clouds for High Intensity Focused Ultrasound Treatment , 2010 .

[15]  R. Seip,et al.  Noninvasive estimation of tissue temperature response to heating fields using diagnostic ultrasound , 1995, IEEE Transactions on Biomedical Engineering.

[16]  Michel Bertrand,et al.  Monitoring the formation of thermal lesions with heat-induced echo-strain imaging: a feasibility study. , 2005, Ultrasound in medicine & biology.

[17]  John R. Ballard,et al.  Adaptive Transthoracic Refocusing of Dual-Mode Ultrasound Arrays , 2010, IEEE Transactions on Biomedical Engineering.

[18]  K Hynynen,et al.  MRI feedback temperature control for focused ultrasound surgery. , 2003, Physics in medicine and biology.

[19]  Wen-Zhi Chen,et al.  Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization. , 2005, Radiology.

[20]  Emad S. Ebbini Noninvasive two-dimensional temperature imaging for guidance of thermal therapy , 2006, 3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro, 2006..

[21]  J A de Zwart,et al.  Hyperthermia by MR‐guided focused ultrasound: Accurate temperature control based on fast MRI and a physical model of local energy deposition and heat conduction , 2000, Magnetic resonance in medicine.

[22]  G. Trahey,et al.  On the feasibility of remote palpation using acoustic radiation force. , 2001, The Journal of the Acoustical Society of America.

[23]  C. Damianou,et al.  Noninvasive temperature estimation in tissue via ultrasound echo-shifts. Part I. Analytical model. , 1996, The Journal of the Acoustical Society of America.

[24]  W. Dewey,et al.  Thermal dose determination in cancer therapy. , 1984, International journal of radiation oncology, biology, physics.

[25]  E. Ebbini,et al.  Deep localized hyperthermia with ultrasound-phased arrays using the pseudoinverse pattern synthesis method , 1990 .

[26]  R. Takagi,et al.  Enhancement of Localized Heating by Ultrasonically Induced Cavitation in High Intensity Focused Ultrasound Treatment , 2010 .

[27]  Emad S. Ebbini,et al.  Real-Time 2-D Temperature Imaging Using Ultrasound , 2010, IEEE Transactions on Biomedical Engineering.

[28]  John Bischof,et al.  Real-time monitoring of thermal and mechanical response to sub-therapeutic HIFU beams in vivo , 2010, 2010 IEEE International Ultrasonics Symposium.

[29]  C M Collins,et al.  Adaptive Real-Time Closed-Loop Temperature Control for Ultrasound Hyperthermia Using Magnetic Resonance Thermometry. , 2005, Concepts in magnetic resonance. Part B, Magnetic resonance engineering.

[30]  Victor Frenkel,et al.  Delivery of systemic chemotherapeutic agent to tumors by using focused ultrasound: study in a murine model. , 2005, Radiology.

[31]  Jean-François Geschwind,et al.  MRI guidance of focused ultrasound therapy of uterine fibroids: early results. , 2004, AJR. American journal of roentgenology.

[32]  P. VanBaren,et al.  Two-dimensional temperature estimation using diagnostic ultrasound , 1998, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[33]  J Y Chapelon,et al.  New piezoelectric transducers for therapeutic ultrasound. , 2000, Ultrasound in medicine & biology.

[34]  T. Bowen,et al.  In vivo temperature dependence of ultrasound speed in tissue and its application to noninvasive temperature monitoring. , 1979, Ultrasonic imaging.