Opioid withdrawal: role in addiction and neural mechanisms

[1]  Sara R. Jones,et al.  Altered Accumbal Dopamine Terminal Dynamics Following Chronic Heroin Self-Administration , 2022, International journal of molecular sciences.

[2]  Yue Feng,et al.  The Basolateral Amygdala to Ventral Hippocampus Circuit Controls Anxiety-Like Behaviors Induced by Morphine Withdrawal , 2022, Frontiers in Cellular Neuroscience.

[3]  M. J. Nobre,et al.  Contributions of the GABAergic system of the prelimbic cortex and basolateral amygdala to morphine withdrawal-induced contextual fear , 2022, Physiology & Behavior.

[4]  S. Hallermann,et al.  An action potential initiation mechanism in distal axons for the control of dopamine release , 2022, Science.

[5]  F. Fernández-Gómez,et al.  Molecular Mechanisms Underlying the Retrieval and Extinction of Morphine Withdrawal-Associated Memories in the Basolateral Amygdala and Dentate Gyrus , 2022, Biomedicines.

[6]  Fan Wang,et al.  CRHCeA→VTA inputs inhibit the positive ensembles to induce negative effect of opiate withdrawal , 2021, Molecular Psychiatry.

[7]  Y. Shaham,et al.  Sex differences in the effect of chronic delivery of the buprenorphine analogue BU08028 on heroin relapse and choice in a rat model of opioid maintenance , 2021, British journal of pharmacology.

[8]  N. Graziane,et al.  Anterior cingulate cortex is necessary for spontaneous opioid withdrawal and withdrawal-induced hyperalgesia in male mice , 2021, Neuropsychopharmacology.

[9]  M. Martel,et al.  Day-to-day opioid withdrawal symptoms, psychological distress, and opioid craving in patients with chronic pain prescribed opioid therapy. , 2021, Drug and alcohol dependence.

[10]  K. Berridge,et al.  Incentive motivation: ‘wanting’ roles of central amygdala circuitry , 2021, Behavioural Brain Research.

[11]  A. K. Radke,et al.  Studying Sex Differences in Rodent Models of Addictive Behavior , 2021, Current protocols.

[12]  Stephanie A. Carmack,et al.  Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction , 2021, Science Advances.

[13]  A. Holmes,et al.  Advances in understanding meso‐cortico‐limbic‐striatal systems mediating risky reward seeking , 2021, Journal of neurochemistry.

[14]  K. Berridge,et al.  Activating Corticotropin-Releasing Factor Systems in the Nucleus Accumbens, Amygdala, and Bed Nucleus of Stria Terminalis: Incentive Motivation or Aversive Motivation? , 2021, Biological Psychiatry.

[15]  J. Navarro-Zaragoza,et al.  Naloxone-induced conditioned place aversion score and extinction period are higher in C57BL/6J morphine-dependent mice than in Swiss: Role of HPA axis , 2021, Pharmacology Biochemistry and Behavior.

[16]  A. K. Radke,et al.  Aversion-resistant fentanyl self-administration in mice , 2020, Psychopharmacology.

[17]  G. Aston-Jones,et al.  Intermittent self‐administration of fentanyl induces a multifaceted addiction state associated with persistent changes in the orexin system , 2020, Addiction biology.

[18]  M. Holahan,et al.  The effects of morphine withdrawal and conditioned withdrawal on memory consolidation and c‐Fos expression in the central amygdala , 2020, Addiction biology.

[19]  Ke Wu,et al.  Disinhibition of PVN-projecting GABAergic neurons in AV region in BNST participates in visceral hypersensitivity in rats , 2020, Psychoneuroendocrinology.

[20]  Y. Hou,et al.  GluA1 in central amygdala increases pain but inhibits opioid withdrawal-induced aversion , 2020, Molecular pain.

[21]  Patrick E. Rothwell,et al.  Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system , 2020, Neuropsychopharmacology.

[22]  R. Raffa,et al.  Opioid withdrawal symptoms, a consequence of chronic opioid use and opioid use disorder: Current understanding and approaches to management , 2020, Journal of clinical pharmacy and therapeutics.

[23]  D. Epstein.  Let’s agree to agree: a comment on Hogarth (2020), with a plea for not-so-competing theories of addiction , 2020, Neuropsychopharmacology.

[24]  Y. Shaham,et al.  Effect of the dopamine stabilizer (-)-OSU6162 on potentiated incubation of opioid craving after electric barrier-induced voluntary abstinence , 2020, Neuropsychopharmacology.

[25]  L. Hogarth.  Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory , 2020, Neuropsychopharmacology.

[26]  J. Bell,et al.  Medication Treatment of Opioid Use Disorder , 2020, Biological Psychiatry.

[27]  G. Koob.  Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia, and Negative Reinforcement , 2020, Biological Psychiatry.

[28]  J. Navarro-Zaragoza,et al.  Conditioned aversive memory associated with morphine withdrawal increases brain‐derived neurotrophic factor in dentate gyrus and basolateral amygdala , 2020, Addiction biology.

[29]  Karl T. Schmidt,et al.  Inhibitory transmission in the bed nucleus of the stria terminalis in male and female mice following morphine withdrawal , 2020, Addiction biology.

[30]  G. Di Chiara,et al.  Addiction theory matters—Why there is no dependence on caffeine or antidepressant medication , 2020, Addiction biology.

[31]  M. Milanés,et al.  Role of glucocorticoids on noradrenergic and dopaminergic neurotransmission within the basolateral amygdala and dentate gyrus during morphine withdrawal place aversion , 2020, Addiction biology.

[32]  A. Newman,et al.  Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats , 2020, Frontiers in Behavioral Neuroscience.

[33]  K. Rice,et al.  Sex differences in oral oxycodone self‐administration and stress‐primed reinstatement in rats , 2019, Addiction biology.

[34]  B. Topkara,et al.  The role of adenosine A1 receptors in the nucleus accumbens during morphine withdrawal , 2019, Clinical and experimental pharmacology & physiology.

[35]  M. Fanselow,et al.  Chronic opioid pretreatment potentiates the sensitization of fear learning by trauma , 2019, Neuropsychopharmacology.

[36]  G. Koob,et al.  Refractory dependence on opioid analgesics. , 2019, Pain.

[37]  Y. Shaham,et al.  Operant Social Reward Decreases Incubation of Heroin Craving in Male and Female Rats , 2019, Biological Psychiatry.

[38]  J. Gewirtz,et al.  Higher anhedonia during withdrawal from initial opioid exposure is protective against subsequent opioid self-administration in rats , 2019, bioRxiv.

[39]  M. Carroll,et al.  Effects of voluntary exercise and sex on multiply-triggered heroin reinstatement in male and female rats , 2019, Psychopharmacology.

[40]  Yu-Jun Wang,et al.  Proteomic analysis of male rat nucleus accumbens, dorsal hippocampus and amygdala on conditioned place aversion induced by morphine withdrawal , 2019, Behavioural Brain Research.

[41]  C. Gipson,et al.  Non-Opioid Neurotransmitter Systems that Contribute to the Opioid Withdrawal Syndrome: A Review of Preclinical and Human Evidence , 2019, The Journal of Pharmacology and Experimental Therapeutics.

[42]  H. Azizi,et al.  Synergistic effect of orexin-glutamate co-administration on spontaneous discharge rate of locus coeruleus neurons in morphine-dependent rats , 2019, Neuroscience Letters.

[43]  S. M. Bobzean,et al.  Sex differences in the expression of morphine withdrawal symptoms and associated activity in the tail of the ventral tegmental area , 2019, Neuroscience Letters.

[44]  C. Gaveriaux-Ruff,et al.  Mu opioid receptors in the medial habenula contribute to naloxone aversion , 2019, Neuropsychopharmacology.

[45]  W. Solecki,et al.  Noradrenergic and corticosteroid receptors regulate somatic and motivational symptoms of morphine withdrawal , 2019, Behavioural Brain Research.

[46]  P. Zheng,et al.  Crucial role of feedback signals from prelimbic cortex to basolateral amygdala in the retrieval of morphine withdrawal memory , 2019, Science Advances.

[47]  T. Kosten,et al.  Review article: Effective management of opioid withdrawal symptoms: A gateway to opioid dependence treatment , 2019, The American journal on addictions.

[48]  H. Monbouquette,et al.  Nucleus Accumbens Cholinergic Interneurons Oppose Cue-Motivated Behavior , 2019, Biological Psychiatry.

[49]  C. Grella,et al.  An examination of motives for tramadol and heroin use in an Egyptian sample , 2018, Journal of addictive diseases.

[50]  M. Field,et al.  Are animal models of addiction useful? , 2019, Addiction.

[51]  K. Berridge,et al.  Optogenetic self-stimulation in the nucleus accumbens: D1 reward versus D2 ambivalence , 2018, PloS one.

[52]  V. Rees,et al.  Negative experiences of pain and withdrawal create barriers to abscess care for people who inject heroin. A mixed methods analysis. , 2018, Drug and alcohol dependence.

[53]  Y. Shaham,et al.  Role of mu, but not delta or kappa, opioid receptors in context‐induced reinstatement of oxycodone seeking , 2018, The European journal of neuroscience.

[54]  J. Berke.  What does dopamine mean? , 2018, Nature Neuroscience.

[55]  C. Salzman,et al.  Basolateral amygdala circuitry in positive and negative valence , 2018, Current Opinion in Neurobiology.

[56]  A. Lüthi,et al.  New perspectives on central amygdala function , 2018, Current Opinion in Neurobiology.

[57]  Mark J. Thomas,et al.  Opioid and Psychostimulant Plasticity: Targeting Overlap in Nucleus Accumbens Glutamate Signaling. , 2018, Trends in pharmacological sciences.

[58]  G. Koob,et al.  Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST) , 2017, Psychopharmacology.

[59]  A. Makriyannis,et al.  CB1 Receptor Antagonism in the Bed Nucleus of the Stria Terminalis Interferes With Affective Opioid Withdrawal in Rats , 2017, Behavioral neuroscience.

[60]  Nadine Gogolla.  The insular cortex , 2017, Current Biology.

[61]  T. Cicero,et al.  Understanding the demand side of the prescription opioid epidemic: Does the initial source of opioids matter? , 2017, Drug and alcohol dependence.

[62]  Y. Shaham,et al.  Incubation of Methamphetamine but not Heroin Craving After Voluntary Abstinence in Male and Female Rats , 2017, Neuropsychopharmacology.

[63]  S. Tonegawa,et al.  Basolateral to Central Amygdala Neural Circuits for Appetitive Behaviors , 2017, Neuron.

[64]  K. Wassum,et al.  Amygdala mu‐opioid receptors mediate the motivating influence of cue‐triggered reward expectations , 2017, The European journal of neuroscience.

[65]  C. Green,et al.  Patient-reported pathways to opioid use disorders and pain-related barriers to treatment engagement. , 2017, Journal of substance abuse treatment.

[66]  Nathan T. Rodeberg,et al.  Reciprocal Catecholamine Changes during Opiate Exposure and Withdrawal , 2017, Neuropsychopharmacology.

[67]  E. Chartoff,et al.  Oxycodone self-administration in male and female rats , 2017, Psychopharmacology.

[68]  K. Kovács,et al.  Different contribution of glucocorticoids in the basolateral amygdala to the formation and expression of opiate withdrawal-associated memories , 2016, Psychoneuroendocrinology.

[69]  C. P. Ford,et al.  Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission , 2016, Scientific Reports.

[70]  Joseph W. Frank,et al.  Patients' Perspectives on Tapering of Chronic Opioid Therapy: A Qualitative Study. , 2016, Pain medicine.

[71]  Roy J. Vaz,et al.  Proarrhythmic mechanisms of the common anti-diarrheal medication loperamide: revelations from the opioid abuse epidemic , 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

[72]  Lan Ma,et al.  Parvalbumin Interneurons of Central Amygdala Regulate the Negative Affective States and the Expression of Corticotrophin-Releasing Hormone During Morphine Withdrawal , 2016, The international journal of neuropsychopharmacology.

[73]  B. Cravatt,et al.  Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats , 2016, Neuropsychopharmacology.

[74]  S. Ostlund,et al.  Inflated reward value in early opiate withdrawal , 2016, Addiction biology.

[75]  A. P. Varani,et al.  Baclofen prevents the elevated plus maze behavior and BDNF expression during naloxone precipitated morphine withdrawal in male and female mice , 2016, Synapse.

[76]  M. Lebow,et al.  Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders , 2016, Molecular Psychiatry.

[77]  Yingjie Zhu,et al.  A thalamic input to the nucleus accumbens mediates opiate dependence , 2016, Nature.

[78]  Alex Harocopos,et al.  Circumstances and contexts of heroin initiation following non-medical opioid analgesic use in New York City. , 2016, The International journal on drug policy.

[79]  Y. Shaham,et al.  Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress , 2016, Neuropsychopharmacology.

[80]  R. Ciccocioppo,et al.  Pioglitazone attenuates the opioid withdrawal and vulnerability to relapse to heroin seeking in rodents , 2016, Psychopharmacology.

[81]  Megan E. Piper,et al.  Withdrawal: Expanding a Key Addiction Construct. , 2015, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[82]  P. Janak,et al.  Dopamine Prediction Errors in Reward Learning and Addiction: From Theory to Neural Circuitry , 2015, Neuron.

[83]  A. Izquierdo,et al.  The basolateral amygdala in reward learning and addiction , 2015, Neuroscience & Biobehavioral Reviews.

[84]  J. Younger,et al.  Acute opioid withdrawal is associated with increased neural activity in reward-processing centers in healthy men: A functional magnetic resonance imaging study. , 2015, Drug and alcohol dependence.

[85]  S. Read,et al.  Revisiting the role of the insula in addiction , 2015, Trends in Cognitive Sciences.

[86]  R. Vertes,et al.  Limbic circuitry of the midline thalamus , 2015, Neuroscience & Biobehavioral Reviews.

[87]  Kathryn C Schierberl,et al.  The kappa-opioid receptor antagonist, nor-binaltorphimine (nor-BNI), decreases morphine withdrawal and the consequent conditioned place aversion in rats , 2015, Behavioural Brain Research.

[88]  D. Ramos-Ortolaza,et al.  Development of conditioned place aversion to spontaneous morphine withdrawal during estradiol replacement , 2015 .

[89]  A. Baroja-Mazo,et al.  Sex Differences between CRF1 Receptor Deficient Mice following Naloxone-Precipitated Morphine Withdrawal in a Conditioned Place Aversion Paradigm: Implication of HPA Axis , 2015, PloS one.

[90]  A. K. Radke,et al.  Intracranial self-stimulation reward thresholds during morphine withdrawal in rats bred for high (HiS) and low (LoS) saccharin intake , 2015, Brain Research.

[91]  G. Koob,et al.  Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence‐induced hyperalgesia , 2015, Addiction biology.

[92]  M. Lai,et al.  Continuous infusion versus intermittent bolus dosing of morphine: a comparison of analgesia, tolerance, and subsequent voluntary morphine intake. , 2014, Journal of psychiatric research.

[93]  A. Zangen,et al.  Smoking Cessation Induced by Deep Repetitive Transcranial Magnetic Stimulation of the Prefrontal and Insular Cortices: A Prospective, Randomized Controlled Trial , 2014, Biological Psychiatry.

[94]  J. Galligan,et al.  Molecular Physiology of Enteric Opioid Receptors , 2014, American journal of gastroenterology supplements.

[95]  R. McHugh,et al.  Reasons for opioid use among patients with dependence on prescription opioids: the role of chronic pain. , 2014, Journal of substance abuse treatment.

[96]  G. Siggins,et al.  Acute morphine alters GABAergic transmission in the central amygdala during naloxone-precipitated morphine withdrawal: role of cyclic AMP , 2014, Front. Integr. Neurosci..

[97]  E. Davis,et al.  New insights into the role of perinatal HPA-axis dysregulation in postpartum depression , 2013, Neuropeptides.

[98]  A. Pisani,et al.  Powerful inhibitory action of mu opioid receptors (MOR) on cholinergic interneuron excitability in the dorsal striatum , 2013, Neuropharmacology.

[99]  G. Koob.  Negative reinforcement in drug addiction: the darkness within , 2013, Current Opinion in Neurobiology.

[100]  N. Sui,et al.  Effects of inactivating the agranular or granular insular cortex on the acquisition of the morphine-induced conditioned place preference and naloxone-precipitated conditioned place aversion in rats , 2013, Journal of psychopharmacology.

[101]  J. Gewirtz,et al.  Reduced emotional signs of opiate withdrawal in rats selectively bred for low (LoS) versus high (HiS) saccharin intake , 2013, Psychopharmacology.

[102]  C. Moine,et al.  CRF2 receptor-deficiency eliminates opiate withdrawal distress without impairing stress coping , 2012, Molecular Psychiatry.

[103]  M. Laorden,et al.  Glucocorticoids Regulation of FosB/ΔFosB Expression Induced by Chronic Opiate Exposure in the Brain Stress System , 2012, PloS one.

[104]  J. Navarro-Zaragoza,et al.  Role of Corticotropin-Releasing Factor (CRF) Receptor-1 on the Catecholaminergic Response to Morphine Withdrawal in the Nucleus Accumbens (NAc) , 2012, PloS one.

[105]  J. Gewirtz,et al.  Increased Dopamine Receptor Activity in the Nucleus Accumbens Shell Ameliorates Anxiety during Drug Withdrawal , 2012, Neuropsychopharmacology.

[106]  K. Kovács,et al.  Hypothalamic Orexin-A Neurons Are Involved in the Response of the Brain Stress System to Morphine Withdrawal , 2012, PloS one.

[107]  B. Walker,et al.  The effect of intermittent alcohol vapor or pulsatile heroin on somatic and negative affective indices during spontaneous withdrawal in Wistar rats , 2012, Psychopharmacology.

[108]  G. Koob,et al.  Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: Alleviation by CRF1 receptor antagonism , 2012, Neuropharmacology.

[109]  John A. Dani,et al.  Withdrawal from Chronic Nicotine Exposure Alters Dopamine Signaling Dynamics in the Nucleus Accumbens , 2012, Biological Psychiatry.

[110]  Yonghui Li,et al.  Inhibition of the acquisition of conditioned place aversion by dopaminergic lesions of the central nucleus of the amygdala in morphine-treated rats. , 2012, Physiological research.

[111]  Patrick E. Rothwell,et al.  Protracted manifestations of acute dependence after a single morphine exposure , 2012, Psychopharmacology.

[112]  E. E. Bagley,et al.  Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors , 2011, Nature Neuroscience.

[113]  S. Heiwe,et al.  Potential risk factors associated with risk for drop-out and relapse during and following withdrawal of opioid prescription medication. , 2011, European journal of pain.

[114]  E. Meloni,et al.  Kappa Opioid Receptor Signaling in the Basolateral Amygdala Regulates Conditioned Fear and Anxiety in Rats , 2011, Biological Psychiatry.

[115]  E. Walker,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[116]  Rajita Sinha,et al.  Translational and reverse translational research on the role of stress in drug craving and relapse , 2011, Psychopharmacology.

[117]  N. Volkow,et al.  Neurocircuitry of Addiction , 2010, Neuropsychopharmacology.

[118]  Mark J. Thomas,et al.  Episodic Withdrawal Promotes Psychomotor Sensitization to Morphine , 2010, Neuropsychopharmacology.

[119]  J. Mirnajafi-zadeh,et al.  Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats , 2010, Neuroscience Letters.

[120]  Mark J. Thomas,et al.  Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis , 2009, Neuropharmacology.

[121]  A. Bruijnzeel.  kappa-Opioid receptor signaling and brain reward function , 2009, Brain Research Reviews.

[122]  M. Agar,et al.  Incarceration and Opioid Withdrawal: The Experiences of Methadone Patients and Out-of-Treatment Heroin Users , 2009, Journal of psychoactive drugs.

[123]  D. van der Kooy,et al.  Different neural systems mediate morphine reward and its spontaneous withdrawal aversion , 2009, The European journal of neuroscience.

[124]  P. Phillips,et al.  Phasic dopamine release in appetitive behaviors and drug addiction. , 2009, Current drug abuse reviews.

[125]  M. Brandão,et al.  GABA and opioid mechanisms of the central amygdala underlie the withdrawal-potentiated startle from acute morphine , 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[126]  K. Rice,et al.  Mechanisms of Withdrawal-Associated Increases in Heroin Self-Administration: Pharmacologic Modulation of Heroin vs Food Choice in Heroin-Dependent Rhesus Monkeys , 2009, Neuropsychopharmacology.

[127]  G. Koob,et al.  The α1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration , 2009, Pharmacology Biochemistry and Behavior.

[128]  A. Murphy,et al.  The Role of the Periaqueductal Gray in the Modulation of Pain in Males and Females: Are the Anatomy and Physiology Really that Different? , 2009, Neural plasticity.

[129]  I. Mirzaii-Dizgah,et al.  Attenuation of morphine withdrawal signs by a GABAB receptor agonist in the locus coeruleus of rats , 2009, Behavioural Brain Research.

[130]  Rajita Sinha,et al.  Modeling stress and drug craving in the laboratory: implications for addiction treatment development , 2009, Addiction biology.

[131]  S. Mague,et al.  Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats , 2009, Psychopharmacology.

[132]  V. Pickel,et al.  Conditional deletion of the NMDA-NR1 receptor subunit gene in the central nucleus of the amygdala inhibits naloxone-induced conditioned place aversion in morphine-dependent mice , 2008, Experimental Neurology.

[133]  S. Nicola,et al.  Basolateral Amygdala Neurons Facilitate Reward-Seeking Behavior by Exciting Nucleus Accumbens Neurons , 2008, Neuron.

[134]  C. Moine,et al.  Reactivity and plasticity in the amygdala nuclei during opiate withdrawal conditioning: Differential expression of c-fos and arc immediate early genes , 2008, Neuroscience.

[135]  Y. Kitamura,et al.  [Involvement of the amygdala on place aversion induced by naloxone in single-dose morphine-treated rats]. , 2008, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[136]  Yi-lang Tang,et al.  Dysfunction of the Hypothalamic–Pituitary–Adrenal Axis in Opioid Dependent Subjects: Effects of Acute and Protracted Abstinence , 2008, The American journal of drug and alcohol abuse.

[137]  D. Gutman,et al.  The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal. , 2007, European journal of pharmacology.

[138]  G. Schulteis,et al.  Rapid neuroadaptation in the nucleus accumbens and bed nucleus of the stria terminalis mediates suppression of operant responding during withdrawal from acute opioid dependence , 2007, Neuroscience.

[139]  H. Damasio,et al.  Damage to the Insula Disrupts Addiction to Cigarette Smoking , 2007, Science.

[140]  J. Gewirtz,et al.  Double dissociation in the neural substrates of acute opiate dependence as measured by withdrawal-potentiated startle , 2006, Neuroscience.

[141]  S. Watson,et al.  HPA axis function in mood disorders , 2006 .

[142]  S. Negus.  Choice between Heroin and Food in Nondependent and Heroin-Dependent Rhesus Monkeys: Effects of Naloxone, Buprenorphine, and Methadone , 2006, Journal of Pharmacology and Experimental Therapeutics.

[143]  Y. Suzuki,et al.  Involvement of the bed nucleus of the stria terminalis activated by the central nucleus of the amygdala in the negative affective component of morphine withdrawal in rats , 2005, Neuroscience.

[144]  F. Papaleo,et al.  The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[145]  E. Tzavara,et al.  A role for cannabinoid CB1 receptors in mood and anxiety disorders , 2005, Behavioural pharmacology.

[146]  E. E. Bagley,et al.  Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine , 2005, British journal of pharmacology.

[147]  G. Koob,et al.  Buprenorphine and a CRF1 Antagonist Block the Acquisition of Opiate Withdrawal-Induced Conditioned Place Aversion in Rats , 2005, Neuropsychopharmacology.

[148]  Serge H. Ahmed.  Addiction as Compulsive Reward Prediction , 2004, Science.

[149]  A. Redish,et al.  Addiction as a Computational Process Gone Awry , 2004, Science.

[150]  K. Gysling,et al.  Role of noradrenergic projections to the bed nucleus of the stria terminalis in the regulation of the hypothalamic–pituitary–adrenal axis , 2004, Brain Research Reviews.

[151]  F. Leri,et al.  Methadone Maintenance Reduces Heroin- and Cocaine-Induced Relapse without Affecting Stress-Induced Relapse in a Rodent Model of Poly-Drug Use , 2004, Neuropsychopharmacology.

[152]  R. Wise.  Dopamine, learning and motivation , 2004, Nature Reviews Neuroscience.

[153]  T. Day,et al.  Effect of naloxone-precipitated morphine withdrawal on c-fos expression in rat corticotropin-releasing hormone neurons in the paraventricular hypothalamus and extended amygdala , 2004, Neuroscience Letters.

[154]  C. Konradi,et al.  Effects of Naloxone‐Precipitated Morphine Withdrawal on Glutamate‐Mediated Signaling in Striatal Neurons in Vitro , 2003, Annals of the New York Academy of Sciences.

[155]  H. Houshyar,et al.  Intermittent Morphine Administration Induces Dependence and is a Chronic Stressor in Rats , 2003, Neuropsychopharmacology.

[156]  P. Veinante,et al.  c‐Fos and peptide immunoreactivities in the central extended amygdala of morphine‐dependent rats after naloxone‐precipitated withdrawal , 2003, The European journal of neuroscience.

[157]  Stephen Maren.  The Amygdala, Synaptic Plasticity, and Fear Memory , 2003, Annals of the New York Academy of Sciences.

[158]  J. García-Borrón,et al.  Regulation of tyrosine hydroxylase levels and activity and Fos expression during opioid withdrawal in the hypothalamic PVN and medulla oblongata catecholaminergic cell groups innervating the PVN , 2003, The European journal of neuroscience.

[159]  J. Gewirtz,et al.  Elevated startle during withdrawal from acute morphine: a model of opiate withdrawal and anxiety , 2003, Psychopharmacology.

[160]  C. Le Moine,et al.  Neural correlates of the motivational and somatic components of naloxone‐precipitated morphine withdrawal , 2002, The European journal of neuroscience.

[161]  T. Nakagawa,et al.  Involvement of glutamate receptors within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats. , 2002, Japanese journal of pharmacology.

[162]  A. Dickinson,et al.  The role of withdrawal in heroin addiction: enhances reward or promotes avoidance? , 2001, Nature Neuroscience.

[163]  L. Parsons,et al.  Compulsive Drug‐Seeking Behavior and Relapse , 2001 .

[164]  J T Williams,et al.  Cellular and synaptic adaptations mediating opioid dependence. , 2001, Physiological reviews.

[165]  K. Berridge,et al.  Incentive-sensitization and addiction. , 2001, Addiction.

[166]  K. Gysling,et al.  Chronic Morphine Treatment and Withdrawal Increase Extracellular Levels of Norepinephrine in the Rat Bed Nucleus of the Stria Terminalis , 2000, Journal of neurochemistry.

[167]  S. H. Ahmed,et al.  Conditioning and opiate withdrawal , 2000, Nature.

[168]  G. Aston-Jones,et al.  Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion , 2000, Nature.

[169]  M. Laorden,et al.  Noradrenergic and Dopaminergic Activity in the Hypothalamic Paraventricular Nucleus after Naloxone-Induced Morphine Withdrawal , 2000, Neuroendocrinology.

[170]  G. Aston-Jones,et al.  The Bed Nucleus of the Stria Terminalis: A Target Site for Noradrenergic Actions in Opiate Withdrawal , 1999, Annals of the New York Academy of Sciences.

[171]  M. Carroll,et al.  Sex differences in the acquisition of intravenously self-administered cocaine and heroin in rats , 1999, Psychopharmacology.

[172]  G. Koob,et al.  Heroin self-administration in dependent Wistar rats: increased sensitivity to naloxone , 1999, Psychopharmacology.

[173]  M. Pistis,et al.  Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal , 1999, The European journal of neuroscience.

[174]  R. Craft,et al.  Sex differences in development of morphine tolerance and dependence in the rat , 1999, Psychopharmacology.

[175]  JaneR . Taylor,et al.  A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the rat , 1998, Psychopharmacology.

[176]  N. Scherbaum,et al.  Profound Increase in Epinephrine Concentration in Plasma and Cardiovascular Stimulation after [micro sign]‐Opioid Receptor Blockade in Opioid‐addicted Patients during Barbiturate‐induced Anesthesia for Acute Detoxification , 1998, Anesthesiology.

[177]  L. Vanderschuren,et al.  Morphine-induced long-term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen , 1997, Psychopharmacology.

[178]  C. Heyser,et al.  Opiate withdrawal signs precipitated by naloxone following a single exposure to morphine: potentiation with a second morphine exposure , 1997, Psychopharmacology.

[179]  B. Hoebel,et al.  Morphine and naloxone, IP or locally, affect extracellular acetylcholine in the accumbens and prefrontal cortex , 1996, Pharmacology Biochemistry and Behavior.

[180]  E. Kiyatkin,et al.  Functional significance of mesolimbic dopamine , 1995, Neuroscience & Biobehavioral Reviews.

[181]  H. Loh,et al.  Expression of the μ‐Opioid Receptor in CHO Cells: Ability of μ‐Opioid Ligands to Promote α‐Azidoanilido[32P]GTP Labeling of Multiple G Protein α Subunits , 1995 .

[182]  K. Keay,et al.  Increased fos-like immunoreactivity in the periaqueductal gray of anaesthetised rats during opiate withdrawal , 1995, Neuroscience Letters.

[183]  G. Koob,et al.  Suppression of corticotropin‐releasing factor in the amygdala attenuates aversive consequences of morphine withdrawal , 1995, Behavioural pharmacology.

[184]  G. Aston-Jones,et al.  Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome , 1994, Nature.

[185]  G. Aghajanian,et al.  Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study , 1994, Brain Research.

[186]  M Farrell,et al.  Opiate withdrawal. , 1994, Addiction.

[187]  G. Koob,et al.  Neural substrates of opiate withdrawal , 1992, Trends in Neurosciences.

[188]  E. Pothos,et al.  Systemic morphine simultaneously decreases extracellular acetylcholine and increases dopamine in the nucleus accumbens of freely moving rats , 1991, Neuropharmacology.

[189]  F. Tennant,et al.  Abnormal adrenal gland metabolism in opioid addicts: implications for clinical treatment. , 1991, Journal of psychoactive drugs.

[190]  E. Nestler,et al.  Induction of the c-fos proto-oncogene during opiate withdrawal in the locus coeruleus and other regions of rat brain , 1990, Brain Research.

[191]  G. Aghajanian,et al.  Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis , 1989, Brain Research.

[192]  R. Verwer,et al.  Organization of projections from the mediodorsal nucleus of the thalamus to the basolateral complex of the amygdala in the rat , 1989, Brain Research.

[193]  G. Di Chiara,et al.  Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[194]  M. Gossop,et al.  The development of an opiate withdrawal scale (OWS). , 1987, British journal of addiction.

[195]  R. Mucha.  Is the motivational effect of opiate withdrawal reflected by common somatic indices of precipitated withdrawal? A place conditioning study in the rat , 1987, Brain Research.

[196]  F. Nava,et al.  Dissociation of morphine withdrawal diarrhea and jumping in mice by the peripherally selective opioid antagonist SR 58002 C. , 1986, Life sciences.

[197]  D. A. Smith,et al.  Afferent connections to the bed nucleus of the stria terminalis , 1982, Brain Research.

[198]  A. Phillips,et al.  The role of dopamine in maintaining intracranial self-stimulation in the ventral tegmentum, nucleus accumbens, and medial prefrontal cortex. , 1978, Canadian journal of psychology.

[199]  M. Nirenberg,et al.  Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[200]  D. Longnecker,et al.  Naloxone for Antagonism of Morphine‐Induced Respiratory Depression , 1973, Anesthesia and analgesia.

[201]  T. Crow,et al.  A map of the rat mesencephalon for electrical self-stimulation. , 1972, Brain research.

[202]  M. Kreek,et al.  Narcotic blockade. , 1966, Archives of internal medicine.

[203]  James L Olds,et al.  Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. , 1954, Journal of comparative and physiological psychology.

[204]  A. Wikler.  Recent progress in research on the neurophysiologic basis of morphine addiction. , 1948, The American journal of psychiatry.