Local-global interactions and the role of mesoscopic (intermediate-range) elements in brain dynamics

A unifing theory of spatiotemporal brain dynamics should incorporate multiple spatial and temporal scales. Between the microscopic (local) and macroscopic (global) components proposed by Nunez, mesoscopic (intermediate-range) elements should be integral parts of models. The corresponding mathematical formalism requires tools of nonlinear dynamics and the use of aperiodic (chaotic) attractors. Some relations between local-mesoscopic and mesoscopic-global components are outlined.