Think twice: Impulsivity and decision making in obsessive–compulsive disorder

Background and Aims Recent studies have challenged the anxiety-avoidance model of obsessive–compulsive disorder (OCD), linking OCD to impulsivity, risky-decision-making and reward-system dysfunction, which can also be found in addiction and might support the conceptualization of OCD as a behavioral addiction. Here, we conducted an exploratory investigation of the behavioral addiction model of OCD by assessing whether OCD patients are more impulsive, have impaired decision-making, and biased probabilistic reasoning, three core dimensions of addiction, in a sample of OCD patients and healthy controls. Methods We assessed these dimensions on 38 OCD patients and 39 healthy controls with the Barratt Impulsiveness Scale (BIS-11), the Iowa Gambling Task (IGT) and the Beads Task. Results OCD patients had significantly higher BIS-11 scores than controls, in particular on the cognitive subscales. They performed significantly worse than controls on the IGT preferring immediate reward despite negative future consequences, and did not learn from losses. Finally, OCD patients demonstrated biased probabilistic reasoning as reflected by significantly fewer draws to decision than controls on the Beads Task. Conclusions OCD patients are more impulsive than controls and demonstrate risky decision-making and biased probabilistic reasoning. These results might suggest that other conceptualizations of OCD, such as the behavioral addiction model, may be more suitable than the anxiety-avoidance one. However, further studies directly comparing OCD and behavioral addiction patients are needed in order to scrutinize this model.

[1]  W. Edwards,et al.  Conservatism in a simple probability inference task. , 1966, Journal of experimental psychology.

[2]  A. Tversky,et al.  Prospect Theory : An Analysis of Decision under Risk Author ( s ) : , 2007 .

[3]  P. Garety,et al.  Probabilistic Judgements in Deluded and Non-Deluded Subjects , 1988, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[4]  W. Goodman,et al.  The Yale-Brown Obsessive Compulsive Scale. II. Validity. , 1989, Archives of general psychiatry.

[5]  W. Goodman,et al.  The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. , 1989, Archives of general psychiatry.

[6]  A. David,et al.  Cognitive neuropsychiatry? , 1993, Psychological Medicine.

[7]  A. Damasio,et al.  Insensitivity to future consequences following damage to human prefrontal cortex , 1994, Cognition.

[8]  Suck-Won Kim,et al.  The Yale-Brown Obsessive-Compulsive Scale: Measures of internal consistency , 1994, Psychiatry Research.

[9]  J. Patton,et al.  Factor structure of the Barratt impulsiveness scale. , 1995, Journal of clinical psychology.

[10]  C. Fear,et al.  Probabilistic reasoning in obsessive–compulsive and delusional disorders , 1997, Psychological Medicine.

[11]  M. First,et al.  Structured clinical interview for DSM-IV axis II personality disorders : SCID-II , 1997 .

[12]  A. Tversky,et al.  Choices, Values, and Frames , 2000 .

[13]  C. Holden 'Behavioral' Addictions: Do They Exist? , 2001, Science.

[14]  E S Barratt,et al.  Psychometric properties of an Italian version of the Barratt Impulsiveness Scale-11 (BIS-11) in nonclinical subjects. , 2001, Journal of clinical psychology.

[15]  E. Hollander,et al.  Treatment non-response in OCD: methodological issues and operational definitions. , 2002, The international journal of neuropsychopharmacology.

[16]  Laura Bellodi,et al.  Decision-making heterogeneity in obsessive-compulsive disorder: ventromedial prefrontal cortex function predicts different treatment outcomes , 2002, Neuropsychologia.

[17]  M. Pelissier,et al.  Deductive and inductive reasoning in obsessive-compulsive disorder. , 2002, The British journal of clinical psychology.

[18]  Roberto Keller,et al.  Frontal lobe dysfunction in pathological gambling patients , 2002, Biological Psychiatry.

[19]  M. First,et al.  Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research version (SCID-I RV) , 2002 .

[20]  H. Westenberg,et al.  The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence. , 2004, The Journal of clinical psychiatry.

[21]  A. Gorini,et al.  Understanding Obsessive–Compulsive Disorder: Focus on Decision Making , 2006, Neuropsychology Review.

[22]  M. Desrocher,et al.  Neuroimaging studies of obsessive-compulsive disorder in adults and children. , 2006, Clinical psychology review.

[23]  Matthias Brand,et al.  Neuropsychological correlates of decision-making in ambiguous and risky situations , 2006, Neural Networks.

[24]  J. Brewer,et al.  The Neurobiology of Substance and Behavioral Addictions , 2006, CNS Spectrums.

[25]  A. Tversky,et al.  Prospect theory: an analysis of decision under risk — Source link , 2007 .

[26]  A. Bechara,et al.  Decisions under ambiguity and decisions under risk: Correlations with executive functions and comparisons of two different gambling tasks with implicit and explicit rules , 2007, Journal of clinical and experimental neuropsychology.

[27]  P Falkai,et al.  Impulsiveness in obsessive–compulsive disorder: results from a family study , 2007, Acta psychiatrica Scandinavica.

[28]  Leandro Malloy-Diniz,et al.  Decision-making impairment is related to serotonin transporter promoter polymorphism in a sample of patients with obsessive–compulsive disorder , 2008, Behavioural Brain Research.

[29]  L. Clark,et al.  Impulsivity as a vulnerability marker for substance-use disorders: Review of findings from high-risk research, problem gamblers and genetic association studies , 2008, Neuroscience & Biobehavioral Reviews.

[30]  T. Robbins,et al.  Serotoninergic regulation of emotional and behavioural control processes , 2008, Trends in Cognitive Sciences.

[31]  Katrin Starcke,et al.  Skin conductance responses during decisions in ambiguous and risky situations in obsessive-compulsive disorder , 2009, Cognitive neuropsychiatry.

[32]  Magnus Dahlbom,et al.  Striatal Dopamine D2/D3 Receptor Availability Is Reduced in Methamphetamine Dependence and Is Linked to Impulsivity , 2009, The Journal of Neuroscience.

[33]  Se Joo Kim,et al.  Temperament and character in subjects with obsessive-compulsive disorder. , 2009, Comprehensive psychiatry.

[34]  C. Reynolds,et al.  Comparisons of methods for multiple hypothesis testing in neuropsychological research. , 2009, Neuropsychology.

[35]  H. Markowitsch,et al.  Dissociation of decisions in ambiguous and risky situations in obsessive–compulsive disorder , 2010, Psychiatry Research.

[36]  M. Cavallini,et al.  Executive Dysfunctions in Obsessive-Compulsive Patients and Unaffected Relatives: Searching for a New Intermediate Phenotype , 2010, Biological Psychiatry.

[37]  Scott D. Lane,et al.  Relationship between impulsivity and decision making in cocaine dependence , 2010, Psychiatry Research.

[38]  P. Dannon,et al.  Pathological gambling: an impulse control disorder? Measurement of impulsivity using neurocognitive tests. , 2010, The Israel Medical Association journal : IMAJ.

[39]  Keith E Stanovich,et al.  Decision-making and cognitive abilities: A review of associations between Iowa Gambling Task performance, executive functions, and intelligence. , 2010, Clinical psychology review.

[40]  J. Bradshaw,et al.  Addiction, compulsive drug seeking, and the role of frontostriatal mechanisms in regulating inhibitory control , 2010, Neuroscience & Biobehavioral Reviews.

[41]  Edward T Bullmore,et al.  Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review , 2010, Neuropsychopharmacology.

[42]  D. Denys Obsessionality & compulsivity: a phenomenology of obsessive-compulsive disorder , 2011, Philosophy, ethics, and humanities in medicine : PEHM.

[43]  H. Corrêa,et al.  Decision-making impairment in obsessive-compulsive disorder as measured by the Iowa Gambling Task. , 2011, Arquivos de neuro-psiquiatria.

[44]  P. Stratta,et al.  Decision-making impairment in schizophrenia: Relationships with positive symptomatology , 2011, Neuroscience Letters.

[45]  K. Mann,et al.  Impaired Decision Making in Opiate Addiction Correlates With Anxiety and Self-directedness but Not Substance Use Parameters , 2011, Journal of addiction medicine.

[46]  R. McNally,et al.  Probabilistic reasoning in patients with body dysmorphic disorder. , 2011, Journal of behavior therapy and experimental psychiatry.

[47]  H. Corrêa,et al.  The relationship between the Met allele of the BDNF Val66Met polymorphism and impairments in decision making under ambiguity in patients with obsessive–compulsive disorder , 2011, Genes, brain, and behavior.

[48]  H. Westenberg,et al.  Dysfunctional Reward Circuitry in Obsessive-Compulsive Disorder , 2011, Biological Psychiatry.

[49]  Y. Janardhan Reddy,et al.  Obsessive–compulsive disorder with and without bipolar disorder , 2011, Psychiatry and clinical neurosciences.

[50]  Talma Hendler,et al.  Functional and structural neural indices of risk aversion in obsessive–compulsive disorder (OCD) , 2012, Psychiatry Research: Neuroimaging.

[51]  P. Stratta,et al.  Decision making, impulsivity, and personality traits in alcohol-dependent subjects. , 2012, The American journal on addictions.

[52]  Stephan F. Miedl,et al.  Altered neural reward representations in pathological gamblers revealed by delay and probability discounting. , 2012, Archives of general psychiatry.

[53]  Elizabeth M. Pratt,et al.  Behavioral and cognitive impulsivity in obsessive–compulsive disorder and eating disorders , 2012, Psychiatry Research.

[54]  K. Cavanagh,et al.  A pilot study exploring the contribution of working memory to “jumping to conclusions” in people with first episode psychosis , 2012, Cognitive neuropsychiatry.

[55]  Leonardo Franklin Fontenelle,et al.  'Impulsive compulsivity' in obsessive-compulsive disorder: a phenotypic marker of patients with poor clinical outcome. , 2012, Journal of psychiatric research.

[56]  P. Salkovskis,et al.  Reasoning bias and belief conviction in obsessive-compulsive disorder and delusions: jumping to conclusions across disorders? , 2012, The British journal of clinical psychology.

[57]  J. Monterosso,et al.  Neuroeconomics and the Study of Addiction , 2012, Biological Psychiatry.

[58]  D. Sasayama,et al.  Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder , 2012, Annals of General Psychiatry.

[59]  The somatic marker affecting decisional processes in obsessive-compulsive disorder , 2012, Cognitive neuropsychiatry.

[60]  R. Boellaard,et al.  Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder , 2013, European Neuropsychopharmacology.

[61]  Thennarasu Kandavel,et al.  Neuropsychological functioning in obsessive-compulsive disorder: are executive functions the key deficit? , 2013, Comprehensive psychiatry.

[62]  V. Starcevic,et al.  Further Support for Five Dimensions of Obsessive-Compulsive Symptoms , 2013, The Journal of nervous and mental disease.

[63]  M. Potenza,et al.  Risk-taking and decision-making in youth: relationships to addiction vulnerability. , 2013, Journal of behavioral addictions.

[64]  R. Haberman,et al.  Prefrontal cortical–striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity , 2013, The European journal of neuroscience.

[65]  S. Ghaemi,et al.  Diagnostic validity of comorbid bipolar disorder and obsessive–compulsive disorder: a systematic review , 2014, Acta Psychiatrica Scandinavica.

[66]  J. Grant,et al.  Impulsive action and impulsive choice across substance and behavioral addictions: cause or consequence? , 2014, Addictive behaviors.

[67]  Jung-Seok Choi,et al.  Similarities and differences among Internet gaming disorder, gambling disorder and alcohol use disorder: A focus on impulsivity and compulsivity , 2014, Journal of behavioral addictions.

[68]  E. Weber,et al.  Capacity to Delay Reward Differentiates Obsessive-Compulsive Disorder and Obsessive-Compulsive Personality Disorder , 2014, Biological Psychiatry.

[69]  K. Blum,et al.  Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubric , 2014, Journal of behavioral addictions.

[70]  E. Hollander,et al.  Characterizing impulsivity profile in patients with obsessive–compulsive disorder , 2014, International journal of psychiatry in clinical practice.

[71]  K. Namkoong,et al.  Further evidence of a dissociation between decision-making under ambiguity and decision-making under risk in obsessive-compulsive disorder. , 2015, Journal of affective disorders.

[72]  J. Sánchez-Meca,et al.  The Yale–Brown Obsessive Compulsive Scale , 2015, Assessment.

[73]  Y. Janardhan Reddy,et al.  Comorbid obsessive compulsive disorder in patients with bipolar-I disorder. , 2015, Journal of affective disorders.

[74]  T. Robbins,et al.  Waiting Impulsivity: The Influence of Acute Methylphenidate and Feedback , 2015, The international journal of neuropsychopharmacology.

[75]  Edward T. Bullmore,et al.  Jumping the Gun: Mapping Neural Correlates of Waiting Impulsivity and Relevance Across Alcohol Misuse , 2016, Biological Psychiatry.