Desymmetrization of meso 7-aza-2,3-bis(phenylsulfonyl) bicyclo[2.2.1]hept-2-ene: a re-examination. Kinetic resolution of racemic 3-arylsulfonyl-7-aza-2-bromobicyclo[2.2.1]hepta-2,5-dienes

[1]  C. Burgey,et al.  A novel and efficient synthesis of 2,5-substituted 1,2,4-triazol-3-ones , 2005 .

[2]  F. Carroll.  Epibatidine structure-activity relationships. , 2004, Bioorganic & medicinal chemistry letters.

[3]  D. Shi,et al.  Homoepiboxidines: further potent agonists for nicotinic receptors. , 2004, Bioorganic & medicinal chemistry.

[4]  P. Vogel,et al.  Efficient resolution of N-Boc-7-azabicyclo[2.2.1]hept-5-en-2-one: formal syntheses of natural epibatidine and its enantiomer , 2003 .

[5]  R. W. Hoffmann.  meso Compounds: stepchildren or favored children of stereoselective synthesis? , 2003, Angewandte Chemie.

[6]  Carla Greco,et al.  Synthesis of 2-Mono- and 2,3-Disubstituted Polycyclic Alkenes , 2002 .

[7]  S. Tiwari,et al.  A short and efficient synthesis of enantiopure (+)-N-Boc-7-azabicyclo[2.2.1]heptan-2-one utilizing an asymmetric desymmetrization protocol: formal total synthesis of (−)-epibatidine , 2001 .

[8]  L. Brieaddy,et al.  Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine analogues. , 2001, Journal of medicinal chemistry.

[9]  P. Carroll,et al.  Synthesis of 5- and 6-(6-Chloro-3-pyridyl)-2-azabicyclo[2.2.0]hexanes. Epibatidine Analogs , 2000 .

[10]  P. Peluso,et al.  Li+ and Na+ switch of enantioselectivity in the desymmetrisation of polycyclic bis(phenylsulfonyl)alkenes by chiral alcohols , 2000 .

[11]  P. Peluso,et al.  Enantioselective Synthesis of Polycyclic Ketones by Desymmetrisation of Bis(phenylsulfonyl)alkenes with Chiral Alcoholates. Control of the Absolute Configuration by a Simple Modification of the Chiral Auxiliary , 1999 .

[12]  C. Cativiela,et al.  Asymmetric synthesis of conformationally constrained 4-hydroxyprolines and their applications to the formal synthesis of (+)-epibatidine , 1999 .

[13]  M. Trudell,et al.  2-Bromoethynyl aryl sulfones as versatile dienophiles: a formal synthesis of epibatidine , 1999 .

[14]  J. Royer,et al.  Expeditious formal synthesis of (±)-epibatidine using diastereoselective bromohydroxylation of aminocyclohexene derivatives , 1998 .

[15]  C. Kibayashi,et al.  Asymmetric total synthesis of (−)-epibatidine , 1998 .

[16]  C. D. Jones,et al.  β-Metallation of bridged alkenyl sulfones: Access to a key intermediate for epibatidine total synthesis , 1998 .

[17]  J. Daly,et al.  Thirty years of discovering arthropod alkaloids in amphibian skin. , 1998, Journal of natural products.

[18]  S. Benetti,et al.  A unified asymmetric approach to substituted hexahydroazepine and 7-azabicyclo[2.2.1]heptane ring systems from D(−)-quinic acid: Application to the formal synthesis of (−)-balanol and (−)-epibatidine , 1997 .

[19]  M. Trudell,et al.  A NEW [4 + 2] CYCLOADDITION STRATEGY FOR THE SYNTHESIS OF N-ACYL-7-AZABICYCLO[2.2.1]HEPTAN-2-ONES: A FORMAL SYNTHESIS OF (±)-EPIBATIDINE , 1997 .

[20]  M. Trudell,et al.  Synthesis of optically pure epibatidine analogs: (1R, 2R, 5S)-2β-(2-chloro-5-pyridinyl)-8-azabicyclo[3.2.1]octane and (1R, 2S, 5S)-2α-(2-chloro-5-pyridinyl)-8-azabicyclo[3.2.1]octane from (−)-cocaine , 1997 .

[21]  O. Lucchi,et al.  Total Enantiotopic Discrimination between Carbon Atoms of a Double Bond in the Reaction of Diolates with meso‐Bis(phenylsulfonyl)alkenes—Synthesis of Enantiopure Ketones , 1997 .

[22]  J. Daly,et al.  Synthesis and nicotinic activity of epiboxidine: an isoxazole analogue of epibatidine. , 1997, European journal of pharmacology.

[23]  B. Trost,et al.  An asymmetric synthesis (−)-epibatidine , 1996 .

[24]  M. Trudell,et al.  Chemistry of 7-Azabicyclo[2.2.1]hepta-2,5-dienes, 7-Azabicyclo[2.2.1]hept-2-enes, and 7-Azabicyclo[2.2.1]heptanes. , 1996, Chemical reviews.

[25]  D. Bai,et al.  Total synthesis of (±) epibatidine , 1996 .

[26]  H. Rapoport,et al.  Synthesis of (+)- and (-)-N-BOC-7-Azabicyclo[2.2.1]heptan-2-ones, Versatile Intermediates for the Enantiospecific Synthesis of (+)- and (-)-Epibatidine and Analogs , 1995 .

[27]  R. Ball,et al.  Total Synthesis and Determination of the Absolute Configuration of Epibatidine , 1994 .

[28]  J. Daly,et al.  Epibatidine, a potent analgetic and nicotinic agonist. , 1994, Molecular pharmacology.

[29]  L. Pannell,et al.  Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an ecuadoran poison frog , 1992 .

[30]  O. Lucchi,et al.  (Z)- and (E)-1-Chloro-1,2-bis(phenylsulfonyl)ethylenes: Synthons of Bis(phenylsulfonyl)acetylene and of Terminal Acetylenes in Cycloaddition Reactions. , 1991 .