An Orthotopic Model of Human Osteosarcoma Growth and Spontaneous Pulmonary Metastasis

[1]  M. Gebhardt,et al.  Survival Data for 648 Patients with Osteosarcoma Treated at One Institution , 2004, Clinical orthopaedics and related research.

[2]  E. Kleinerman,et al.  Increased Fas Expression Reduces the Metastatic Potential of Human Osteosarcoma Cells , 2004, Clinical Cancer Research.

[3]  J. Ioannidis,et al.  Prognostic Significance of TP53 Tumor Suppressor Gene Expression and Mutations in Human Osteosarcoma , 2004, Clinical Cancer Research.

[4]  J. Folkman.  Endogenous angiogenesis inhibitors , 2004, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[5]  H. Kang,et al.  Imaging findings of extrapulmonary metastases of osteosarcoma. , 2004, Clinical imaging.

[6]  M. Berger,et al.  K-ras codon 12 and 13 mutations are correlated with differential patterns of tumor cell dissemination in colorectal cancer patients. , 2004, International journal of oncology.

[7]  K. Yeung,et al.  Raf kinase inhibitor protein: a prostate cancer metastasis suppressor gene. , 2004, Cancer letters.

[8]  A. Huvos,et al.  Expression of LDL receptor‐related protein 5 (LRP5) as a novel marker for disease progression in high‐grade osteosarcoma , 2004, International journal of cancer.

[9]  M. Berger,et al.  Detection of Isolated Tumor Cells by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism for K-ras Mutations in Tissue Samples of 199 Colorectal Cancer Patients , 2004, Clinical Cancer Research.

[10]  Stephen M Hewitt,et al.  The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis , 2004, Nature Medicine.

[11]  A. Heimberger,et al.  A fully human antimelanoma cellular adhesion molecule/MUC18 antibody inhibits spontaneous pulmonary metastasis of osteosarcoma cells in vivo. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[12]  N. Jaffe,et al.  Single and multiple metachronous osteosarcoma tumors after therapy , 2003, Cancer.

[13]  A. Shah,et al.  Right Atrial and Ventricular Thrombus Infiltrated with Osteoblastic Osteosarcoma , 2003, Journal of cardiovascular pharmacology and therapeutics.

[14]  P. Meltzer,et al.  Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[15]  A. Sandberg,et al.  Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: osteosarcoma and related tumors. , 2003, Cancer genetics and cytogenetics.

[16]  W. Winkelmann,et al.  Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  J. Folkman.  Role of angiogenesis in tumor growth and metastasis. , 2002, Seminars in oncology.

[18]  A. Montag,et al.  Cytoplasmic and/or nuclear accumulation of the β‐catenin protein is a frequent event in human osteosarcoma , 2002, International journal of cancer.

[19]  P. Meltzer,et al.  Metastasis-associated differences in gene expression in a murine model of osteosarcoma. , 2001, Cancer research.

[20]  A. Craft,et al.  Survival of children with bone sarcoma in Europe since 1978: results from the EUROCARE study. , 2001, European journal of cancer.

[21]  M. Stevens,et al.  Survival of children with soft-tissue sarcoma in Europe since 1978: results from the EUROCARE study. , 2001, European journal of cancer.

[22]  C. Rinker-Schaeffer,et al.  Metastasis-suppressor genes: a review and perspective on an emerging field. , 2000, Journal of the National Cancer Institute.

[23]  P. Steeg,et al.  Molecular biology of breast cancer metastasis: Genetic regulation of human breast carcinoma metastasis , 2000, Breast Cancer Research.

[24]  P. Picci,et al.  C-myc and c-fos in Human Osteosarcoma: Prognostic Value of mRNA and Protein Expression , 1998, Oncology.

[25]  M. L. Le Beau,et al.  Identification of a novel metastasis-suppressor region on human chromosome 12. , 1998, Cancer research.

[26]  M. Robbin,et al.  The many faces of osteosarcoma. , 1997, Radiographics : a review publication of the Radiological Society of North America, Inc.

[27]  B. Freidlin,et al.  Oncogene alterations in primary, recurrent, and metastatic human bone tumors , 1996, Journal of cellular biochemistry.

[28]  P. Terrier,et al.  Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[29]  E. Holmes,et al.  Pulmonary metastases of stage IIB extremity osteosarcoma and subsequent pulmonary metastases. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[30]  O. Fodstad,et al.  Validity and usefulness of human tumor models established by intratibial cell inoculation in nude rats. , 1994, Cancer research.

[31]  J. Barrett,et al.  A gene involved in control of human cellular senescence on human chromosome 1q , 1994, Molecular and cellular biology.

[32]  W. Akeson,et al.  Development of a novel spontaneous metastasis model of human osteosarcoma transplanted orthotopically into bone of athymic mice. , 1993, Cancer research.

[33]  P. Lollini,et al.  Establishment and characterization of multidrug-resistant human osteosarcoma cell lines. , 1993, Anticancer research.

[34]  D. Haines,et al.  Immunoscintigraphic detection of primary and metastatic spontaneous canine osteosarcoma with F(ab')2 fragments of osteosarcoma-associated monoclonal antibody TP-1. , 1992, Anticancer research.

[35]  I. Elomaa,et al.  The treatment of osteosarcoma: present trends. The Scandinavian Sarcoma Group experience. , 1992, Annals of oncology : official journal of the European Society for Medical Oncology.

[36]  G. Laurent,et al.  * Author for correspondence Summary , 2022 .

[37]  J. Shuster,et al.  The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. , 1986, The New England journal of medicine.

[38]  I. Fidler,et al.  The pathogenesis of cancer metastasis , 1980, Nature.

[39]  A. Hart,et al.  Some prognostic and epidemiologic factors in canine osteosarcoma. , 1979, Journal of the National Cancer Institute.

[40]  J. Rhim,et al.  Characterization of human cells transformed in vitro by n‐methyl‐n'‐nitro‐n‐nitrosoguanidine , 1977, International journal of cancer.

[41]  C. Bradt,et al.  Cultivation in vitro of cells derived from a human osteosarcoma , 1971, Cancer.

[42]  H. Schuller,et al.  Amputation and dexniguldipine as treatment for canine appendicular osteosarcoma , 2005, Journal of Cancer Research and Clinical Oncology.

[43]  M. Rosner,et al.  Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein , 2005, Cell Research.

[44]  E. Kleinerman,et al.  A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies , 2004, Clinical & Experimental Metastasis.

[45]  L. Goodglick,et al.  Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis. , 2004, Advances in cancer research.

[46]  J. Yokota,et al.  Establishment of human osteosarcoma cell lines with high metastatic potential to lungs and their utilities for therapeutic studies on metastatic osteosarcoma , 2004, Clinical & Experimental Metastasis.

[47]  L. Helman,et al.  An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential , 2004, Clinical & Experimental Metastasis.

[48]  J. Yokota,et al.  Biological properties and gene expression associated with metastatic potential of human osteosarcoma , 2004, Clinical & Experimental Metastasis.

[49]  Takashi Takahashi,et al.  K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma. , 2004, The American journal of pathology.

[50]  A. Nakao,et al.  Detection of K-ras mutations in the plasma DNA of pancreatic cancer patients , 2003, Journal of Gastroenterology.

[51]  M. Rubin,et al.  Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. , 2003, Journal of the National Cancer Institute.

[52]  T. Miyamoto,et al.  In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy. , 1998, Cancer gene therapy.

[53]  R. Schneider-Stock,et al.  Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors. , 1998, Pathology, Research and Practice.

[54]  I. Hart,et al.  Metastasis and angiogenesis. , 1990, Acta oncologica.